No (innate immune) training without lactate

Jan van den Bossche

doi:10.1016/j.molcel.2025.05.014

No (innate immune) training without lactate

Jan van den Bossche^*

^*Corresponding author for this work

Vrije Universiteit Amsterdam

Research output: Contribution to journal › Comment/Letter to the editor › Academic

31 Downloads (Pure)

Abstract

A recent study in Cell unveils lactate production and downstream histone lactylation as a new player in the induction of trained immunity.1 It provides insight into the intricate metabolic-epigenetic interplay that governs innate immune memory and offers a potential target to reverse maladaptive trained immunity in chronic inflammatory diseases.

Original language	English
Pages (from-to)	2065-2067
Number of pages	3
Journal	Molecular cell
Volume	85
Issue number	11
DOIs	https://doi.org/10.1016/j.molcel.2025.05.014
Publication status	Published - 5 Jun 2025

Access to Document

10.1016/j.molcel.2025.05.014

No-innate-immune-training-without-lactate.pdfFinal published version, 1.56 MBLicence: Taverne

Cite this

@article{cf0e0808201c444aa02b9ff5c9a37036,

title = "No (innate immune) training without lactate",

abstract = "A recent study in Cell unveils lactate production and downstream histone lactylation as a new player in the induction of trained immunity.1 It provides insight into the intricate metabolic-epigenetic interplay that governs innate immune memory and offers a potential target to reverse maladaptive trained immunity in chronic inflammatory diseases.",

author = "\{van den Bossche\}, Jan",

note = "Publisher Copyright: {\textcopyright} 2025 Elsevier Inc.",

year = "2025",

month = jun,

day = "5",

doi = "10.1016/j.molcel.2025.05.014",

language = "English",

volume = "85",

pages = "2065--2067",

journal = "Molecular cell",

issn = "1097-2765",

publisher = "Cell Press",

number = "11",

}

TY - JOUR

T1 - No (innate immune) training without lactate

AU - van den Bossche, Jan

PY - 2025/6/5

Y1 - 2025/6/5

N2 - A recent study in Cell unveils lactate production and downstream histone lactylation as a new player in the induction of trained immunity.1 It provides insight into the intricate metabolic-epigenetic interplay that governs innate immune memory and offers a potential target to reverse maladaptive trained immunity in chronic inflammatory diseases.

AB - A recent study in Cell unveils lactate production and downstream histone lactylation as a new player in the induction of trained immunity.1 It provides insight into the intricate metabolic-epigenetic interplay that governs innate immune memory and offers a potential target to reverse maladaptive trained immunity in chronic inflammatory diseases.

UR - https://www.scopus.com/pages/publications/105006996462

U2 - 10.1016/j.molcel.2025.05.014

DO - 10.1016/j.molcel.2025.05.014

M3 - Comment/Letter to the editor

C2 - 40480195

SN - 1097-2765

VL - 85

SP - 2065

EP - 2067

JO - Molecular cell

JF - Molecular cell

IS - 11

ER -

No (innate immune) training without lactate

Abstract

Access to Document

Other files and links

Fingerprint

Cite this