Neurological and adrenal dysfunction in the adrenal insufficiency/alacrima/ achalasia (3A) syndrome

D. B. Grant; N. D. Barnes; M. Dumic; M. Ginalska-Malinowska; P. J. Milla; W. V. Petrykowski; R. J. Rowlatt; R. Steendijk; J. H. K. Wales; E. Werder

doi:10.1136/adc.68.6.779

Neurological and adrenal dysfunction in the adrenal insufficiency/alacrima/ achalasia (3A) syndrome

D. B. Grant^*
, N. D. Barnes
, M. Dumic
, M. Ginalska-Malinowska
, P. J. Milla
, W. V. Petrykowski
, R. J. Rowlatt
, R. Steendijk
, J. H. K. Wales
, E. Werder

^*Corresponding author for this work

Hospital for Sick Children
Cambridge University Hospitals NHS Foundation Trust
University of Zagreb
Child Health Centre
University of Freiburg
University Hospitals of Morecambe Bay NHS Foundation Trust
Amsterdam UMC - University of Amsterdam
Sheffield Children's NHS Foundation Trust
University of Zurich

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Review of 20 patients with glucocorticoid deficiency (three cases also with salt loss) associated with absent tear secretion (19 cases) and achalasia of the cardia (15 cases) revealed neurological abnormalities in 17 including hyper-reflexia, muscle weakness, dysarthria, and ataxia together with impaired intelligence and abnormal autonomic function, particularly postural hypotension. These findings indicate that significant neurological problems are common in this multisystem disorder.

Original language	English
Pages (from-to)	779-782
Journal	Archives of disease in childhood
Volume	68
Issue number	6
DOIs	https://doi.org/10.1136/adc.68.6.779
Publication status	Published - 1993
Externally published	Yes

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title = "Neurological and adrenal dysfunction in the adrenal insufficiency/alacrima/ achalasia (3A) syndrome",

abstract = "Review of 20 patients with glucocorticoid deficiency (three cases also with salt loss) associated with absent tear secretion (19 cases) and achalasia of the cardia (15 cases) revealed neurological abnormalities in 17 including hyper-reflexia, muscle weakness, dysarthria, and ataxia together with impaired intelligence and abnormal autonomic function, particularly postural hypotension. These findings indicate that significant neurological problems are common in this multisystem disorder.",

author = "Grant, \{D. B.\} and Barnes, \{N. D.\} and M. Dumic and M. Ginalska-Malinowska and Milla, \{P. J.\} and Petrykowski, \{W. V.\} and Rowlatt, \{R. J.\} and R. Steendijk and Wales, \{J. H. K.\} and E. Werder",

year = "1993",

doi = "10.1136/adc.68.6.779",

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T1 - Neurological and adrenal dysfunction in the adrenal insufficiency/alacrima/ achalasia (3A) syndrome

AU - Grant, D. B.

AU - Barnes, N. D.

AU - Dumic, M.

AU - Ginalska-Malinowska, M.

AU - Milla, P. J.

AU - Petrykowski, W. V.

AU - Rowlatt, R. J.

AU - Steendijk, R.

AU - Wales, J. H. K.

AU - Werder, E.

PY - 1993

Y1 - 1993

N2 - Review of 20 patients with glucocorticoid deficiency (three cases also with salt loss) associated with absent tear secretion (19 cases) and achalasia of the cardia (15 cases) revealed neurological abnormalities in 17 including hyper-reflexia, muscle weakness, dysarthria, and ataxia together with impaired intelligence and abnormal autonomic function, particularly postural hypotension. These findings indicate that significant neurological problems are common in this multisystem disorder.

AB - Review of 20 patients with glucocorticoid deficiency (three cases also with salt loss) associated with absent tear secretion (19 cases) and achalasia of the cardia (15 cases) revealed neurological abnormalities in 17 including hyper-reflexia, muscle weakness, dysarthria, and ataxia together with impaired intelligence and abnormal autonomic function, particularly postural hypotension. These findings indicate that significant neurological problems are common in this multisystem disorder.

UR - https://www.scopus.com/pages/publications/0027324668

UR - https://www.ncbi.nlm.nih.gov/pubmed/8333772

U2 - 10.1136/adc.68.6.779

DO - 10.1136/adc.68.6.779

M3 - Article

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SN - 0003-9888

VL - 68

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EP - 782

JO - Archives of disease in childhood

JF - Archives of disease in childhood

IS - 6

ER -

Neurological and adrenal dysfunction in the adrenal insufficiency/alacrima/ achalasia (3A) syndrome

Abstract

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