Near-fatal persistent anion- and osmolal-gap acidosis due to massive gamma-butyrolactone/ethanol intoxication

Luc Heytens; Hugo Neels; Niels van Regenmortel; Wim van den Brink; Manu Henckes; Sofie Schouwers; Greet Dockx; Cleo L. Crunelle

doi:10.1177/0004563214553278

Near-fatal persistent anion- and osmolal-gap acidosis due to massive gamma-butyrolactone/ethanol intoxication

Luc Heytens
, Hugo Neels
, Niels van Regenmortel
, Wim van den Brink
, Manu Henckes
, Sofie Schouwers
, Greet Dockx
, Cleo L. Crunelle

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

We report a case of an ethanol and massive gamma-butyrolactone (GBL) intoxication, the precursor of the recreational drug gamma-hydroxybutyric acid (GHB), resulting in life-threatening metabolic acidosis (pH 6.5) with a highly increased anion- and osmolal gap. Rapid analysis using gas chromatography revealed a GHB plasma concentration of 4400 mg/L, far above the upper limit concentration of 1000 mg/L found in adult fatalities attributed to GBL. Full recovery was established following supportive treatment including haemodialysis. This is the first report of a combined ethanol/GBL intoxication as a cause of high serum anion- and osmolal-gap metabolic acidosis

Original language	English
Pages (from-to)	283-287
Journal	Annals of clinical biochemistry
Volume	52
Issue number	Part 2
DOIs	https://doi.org/10.1177/0004563214553278
Publication status	Published - 2015

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title = "Near-fatal persistent anion- and osmolal-gap acidosis due to massive gamma-butyrolactone/ethanol intoxication",

abstract = "We report a case of an ethanol and massive gamma-butyrolactone (GBL) intoxication, the precursor of the recreational drug gamma-hydroxybutyric acid (GHB), resulting in life-threatening metabolic acidosis (pH 6.5) with a highly increased anion- and osmolal gap. Rapid analysis using gas chromatography revealed a GHB plasma concentration of 4400 mg/L, far above the upper limit concentration of 1000 mg/L found in adult fatalities attributed to GBL. Full recovery was established following supportive treatment including haemodialysis. This is the first report of a combined ethanol/GBL intoxication as a cause of high serum anion- and osmolal-gap metabolic acidosis",

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doi = "10.1177/0004563214553278",

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T1 - Near-fatal persistent anion- and osmolal-gap acidosis due to massive gamma-butyrolactone/ethanol intoxication

AU - Heytens, Luc

AU - Neels, Hugo

AU - van Regenmortel, Niels

AU - van den Brink, Wim

AU - Henckes, Manu

AU - Schouwers, Sofie

AU - Dockx, Greet

AU - Crunelle, Cleo L.

PY - 2015

Y1 - 2015

N2 - We report a case of an ethanol and massive gamma-butyrolactone (GBL) intoxication, the precursor of the recreational drug gamma-hydroxybutyric acid (GHB), resulting in life-threatening metabolic acidosis (pH 6.5) with a highly increased anion- and osmolal gap. Rapid analysis using gas chromatography revealed a GHB plasma concentration of 4400 mg/L, far above the upper limit concentration of 1000 mg/L found in adult fatalities attributed to GBL. Full recovery was established following supportive treatment including haemodialysis. This is the first report of a combined ethanol/GBL intoxication as a cause of high serum anion- and osmolal-gap metabolic acidosis

AB - We report a case of an ethanol and massive gamma-butyrolactone (GBL) intoxication, the precursor of the recreational drug gamma-hydroxybutyric acid (GHB), resulting in life-threatening metabolic acidosis (pH 6.5) with a highly increased anion- and osmolal gap. Rapid analysis using gas chromatography revealed a GHB plasma concentration of 4400 mg/L, far above the upper limit concentration of 1000 mg/L found in adult fatalities attributed to GBL. Full recovery was established following supportive treatment including haemodialysis. This is the first report of a combined ethanol/GBL intoxication as a cause of high serum anion- and osmolal-gap metabolic acidosis

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DO - 10.1177/0004563214553278

M3 - Article

C2 - 25205856

SN - 0004-5632

VL - 52

SP - 283

EP - 287

JO - Annals of clinical biochemistry

JF - Annals of clinical biochemistry

IS - Part 2

ER -

Near-fatal persistent anion- and osmolal-gap acidosis due to massive gamma-butyrolactone/ethanol intoxication

Abstract

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