Navigating challenges in clinical trials for bullous pemphigoid and pemphigus: learnings from the clinical trial graveyard and an international expert survey

Eva W. H. Korte; Marjolein A. J. Hiel; Maria C. Bolling; Patrick Dunn; D. dée F. Murrell; Victoria P. Werth; Marc Yale; Phyllis I. Spuls; Joost M. Meijer; Barbara Horváth

doi:10.1093/bjd/ljaf366

Navigating challenges in clinical trials for bullous pemphigoid and pemphigus: learnings from the clinical trial graveyard and an international expert survey

Eva W. H. Korte
, Marjolein A. J. Hiel
, Maria C. Bolling
, Patrick Dunn
, D. dée F. Murrell
, Victoria P. Werth
, Marc Yale
, Phyllis I. Spuls
, Joost M. Meijer
, Barbara Horváth

University of Groningen
International Pemphigus and Pemphigoid Foundation
University of New South Wales
VA Medical Center
University of Pennsylvania
University of Amsterdam

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

This study analysed 32 failed drug development trials and surveyed 56 experts in the field of autoimmune bullous diseases to identify key challenges in bullous pemphigoid and pemphigus research. Clinical trials primarily failed due to unmet efficacy endpoints and recruitment difficulties, with experts highlighting the need to improve endpoint selection and patient enrolment strategies through international collaboration to develop more effective trial designs and advance new therapeutic options.

Original language	English
Pages (from-to)	165-167
Number of pages	3
Journal	British journal of dermatology
Volume	194
Issue number	1
DOIs	https://doi.org/10.1093/bjd/ljaf366
Publication status	Published - 1 Jan 2026

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Navigating-challenges-in-clinical-trials-for-bullous-pemphigoid-and-pemphigus.pdfFinal published version, 799 KBLicence: CC BY

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Korte, E. W. H., Hiel, M. A. J., Bolling, M. C., Dunn, P., Murrell, D. D. F., Werth, V. P., Yale, M., Spuls, P. I., Meijer, J. M., & Horváth, B. (2026). Navigating challenges in clinical trials for bullous pemphigoid and pemphigus: learnings from the clinical trial graveyard and an international expert survey. British journal of dermatology, 194(1), 165-167. https://doi.org/10.1093/bjd/ljaf366

@article{2baf6913f22945efa3a8a31aef1127a8,

title = "Navigating challenges in clinical trials for bullous pemphigoid and pemphigus: learnings from the clinical trial graveyard and an international expert survey",

abstract = "This study analysed 32 failed drug development trials and surveyed 56 experts in the field of autoimmune bullous diseases to identify key challenges in bullous pemphigoid and pemphigus research. Clinical trials primarily failed due to unmet efficacy endpoints and recruitment difficulties, with experts highlighting the need to improve endpoint selection and patient enrolment strategies through international collaboration to develop more effective trial designs and advance new therapeutic options.",

author = "Korte, \{Eva W. H.\} and Hiel, \{Marjolein A. J.\} and Bolling, \{Maria C.\} and Patrick Dunn and Murrell, \{D. d{\'e}e F.\} and Werth, \{Victoria P.\} and Marc Yale and Spuls, \{Phyllis I.\} and Meijer, \{Joost M.\} and Barbara Horv{\'a}th",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2025. Published by Oxford University Press on behalf of British Association of Dermatologists.",

year = "2026",

month = jan,

day = "1",

doi = "10.1093/bjd/ljaf366",

language = "English",

volume = "194",

pages = "165--167",

journal = "British journal of dermatology",

issn = "0007-0963",

publisher = "Wiley Blackwell",

number = "1",

}

Korte, EWH, Hiel, MAJ, Bolling, MC, Dunn, P, Murrell, DDF, Werth, VP, Yale, M, Spuls, PI, Meijer, JM & Horváth, B 2026, 'Navigating challenges in clinical trials for bullous pemphigoid and pemphigus: learnings from the clinical trial graveyard and an international expert survey', British journal of dermatology, vol. 194, no. 1, pp. 165-167. https://doi.org/10.1093/bjd/ljaf366

Navigating challenges in clinical trials for bullous pemphigoid and pemphigus: learnings from the clinical trial graveyard and an international expert survey. / Korte, Eva W. H.; Hiel, Marjolein A. J.; Bolling, Maria C. et al.
In: British journal of dermatology, Vol. 194, No. 1, 01.01.2026, p. 165-167.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Navigating challenges in clinical trials for bullous pemphigoid and pemphigus

T2 - learnings from the clinical trial graveyard and an international expert survey

AU - Korte, Eva W. H.

AU - Hiel, Marjolein A. J.

AU - Bolling, Maria C.

AU - Dunn, Patrick

AU - Murrell, D. dée F.

AU - Werth, Victoria P.

AU - Yale, Marc

AU - Spuls, Phyllis I.

AU - Meijer, Joost M.

AU - Horváth, Barbara

PY - 2026/1/1

Y1 - 2026/1/1

N2 - This study analysed 32 failed drug development trials and surveyed 56 experts in the field of autoimmune bullous diseases to identify key challenges in bullous pemphigoid and pemphigus research. Clinical trials primarily failed due to unmet efficacy endpoints and recruitment difficulties, with experts highlighting the need to improve endpoint selection and patient enrolment strategies through international collaboration to develop more effective trial designs and advance new therapeutic options.

AB - This study analysed 32 failed drug development trials and surveyed 56 experts in the field of autoimmune bullous diseases to identify key challenges in bullous pemphigoid and pemphigus research. Clinical trials primarily failed due to unmet efficacy endpoints and recruitment difficulties, with experts highlighting the need to improve endpoint selection and patient enrolment strategies through international collaboration to develop more effective trial designs and advance new therapeutic options.

UR - https://www.scopus.com/pages/publications/105026681051

U2 - 10.1093/bjd/ljaf366

DO - 10.1093/bjd/ljaf366

M3 - Article

C2 - 40971666

SN - 0007-0963

VL - 194

SP - 165

EP - 167

JO - British journal of dermatology

JF - British journal of dermatology

IS - 1

ER -

Navigating challenges in clinical trials for bullous pemphigoid and pemphigus: learnings from the clinical trial graveyard and an international expert survey

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