Naturally HIV-1 seroconverters with lowest viral load have best prognosis, but in time lose control of viraemia

Jaap Goudsmit; Johannes A. Bogaards; Suzanne Jurriaans; Hanneke Schuitemaker; Joep M. A. Lange; Roel A. Coutinho; Gerrit Jan Weverling

doi:10.1097/00002030-200203290-00016

Naturally HIV-1 seroconverters with lowest viral load have best prognosis, but in time lose control of viraemia

Jaap Goudsmit
, Johannes A. Bogaards
, Suzanne Jurriaans
, Hanneke Schuitemaker
, Joep M. A. Lange
, Roel A. Coutinho
, Gerrit Jan Weverling

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Candidate AIDS vaccines are based on the success of monkey studies, showing the ability of vaccine-induced cytotoxic T lymphocytes to control HIV-1 replication. We evaluated the ability to maintain suppression of virus replication in seroconverters with a naturally low level of plasma HIV-1 RNA. No AIDS-defining events were observed at low plasma HIV-1-RNA levels, but a steady loss of CD4 T lymphocytes occurred, and long-term control of viraemia was extremely rare in the natural course of HIV-1 infection

Original language	English
Pages (from-to)	791-793
Number of pages	3
Journal	AIDS (London, England)
Volume	16
Issue number	5
DOIs	https://doi.org/10.1097/00002030-200203290-00016
Publication status	Published - 29 Mar 2002

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1097/00002030-200203290-00016

Cite this

@article{3676db649d9048db8cae3e888da4a41a,

title = "Naturally HIV-1 seroconverters with lowest viral load have best prognosis, but in time lose control of viraemia",

abstract = "Candidate AIDS vaccines are based on the success of monkey studies, showing the ability of vaccine-induced cytotoxic T lymphocytes to control HIV-1 replication. We evaluated the ability to maintain suppression of virus replication in seroconverters with a naturally low level of plasma HIV-1 RNA. No AIDS-defining events were observed at low plasma HIV-1-RNA levels, but a steady loss of CD4 T lymphocytes occurred, and long-term control of viraemia was extremely rare in the natural course of HIV-1 infection",

author = "Jaap Goudsmit and Bogaards, \{Johannes A.\} and Suzanne Jurriaans and Hanneke Schuitemaker and Lange, \{Joep M. A.\} and Coutinho, \{Roel A.\} and Weverling, \{Gerrit Jan\}",

year = "2002",

month = mar,

day = "29",

doi = "10.1097/00002030-200203290-00016",

language = "English",

volume = "16",

pages = "791--793",

journal = "AIDS (London, England)",

issn = "0269-9370",

publisher = "Lippincott Williams and Wilkins",

number = "5",

}

TY - JOUR

T1 - Naturally HIV-1 seroconverters with lowest viral load have best prognosis, but in time lose control of viraemia

AU - Goudsmit, Jaap

AU - Bogaards, Johannes A.

AU - Jurriaans, Suzanne

AU - Schuitemaker, Hanneke

AU - Lange, Joep M. A.

AU - Coutinho, Roel A.

AU - Weverling, Gerrit Jan

PY - 2002/3/29

Y1 - 2002/3/29

N2 - Candidate AIDS vaccines are based on the success of monkey studies, showing the ability of vaccine-induced cytotoxic T lymphocytes to control HIV-1 replication. We evaluated the ability to maintain suppression of virus replication in seroconverters with a naturally low level of plasma HIV-1 RNA. No AIDS-defining events were observed at low plasma HIV-1-RNA levels, but a steady loss of CD4 T lymphocytes occurred, and long-term control of viraemia was extremely rare in the natural course of HIV-1 infection

AB - Candidate AIDS vaccines are based on the success of monkey studies, showing the ability of vaccine-induced cytotoxic T lymphocytes to control HIV-1 replication. We evaluated the ability to maintain suppression of virus replication in seroconverters with a naturally low level of plasma HIV-1 RNA. No AIDS-defining events were observed at low plasma HIV-1-RNA levels, but a steady loss of CD4 T lymphocytes occurred, and long-term control of viraemia was extremely rare in the natural course of HIV-1 infection

UR - https://www.scopus.com/pages/publications/0037192575

U2 - 10.1097/00002030-200203290-00016

DO - 10.1097/00002030-200203290-00016

M3 - Article

C2 - 11964537

SN - 0269-9370

VL - 16

SP - 791

EP - 793

JO - AIDS (London, England)

JF - AIDS (London, England)

IS - 5

ER -

Naturally HIV-1 seroconverters with lowest viral load have best prognosis, but in time lose control of viraemia

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this