Nance-Horan syndrome: linkage analysis in a family from The Netherlands

A. A. Bergen; J. ten Brink; E. J. Schuurman; E. M. Bleeker-Wagemakers

doi:10.1006/geno.1994.1248

Nance-Horan syndrome: linkage analysis in a family from The Netherlands

A. A. Bergen
, J. ten Brink
, E. J. Schuurman
, E. M. Bleeker-Wagemakers

Research output: Contribution to journal › Comment/Letter to the editor › Academic

Abstract

Linkage analysis was carried out in a Dutch family with Nance-Horan (NH) syndrome. Close linkage without recombination between NH and the Xp loci DXS207, DXS43, and DXS365 (zmax = 3.23) was observed. Multipoint linkage analysis and the analysis of recombinations in multiple informative meioses suggest the genetic order Xcen-DMD (exon 49)-DXS451-(NH, DXS207, DXS365, DXS43)-(STS, DXF30)-Xpter. These data refine the localization of the NH locus on the distal Xp

Original language	English
Pages (from-to)	238-240
Journal	Genomics
Volume	21
Issue number	1
DOIs	https://doi.org/10.1006/geno.1994.1248
Publication status	Published - 1994

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title = "Nance-Horan syndrome: linkage analysis in a family from The Netherlands",

abstract = "Linkage analysis was carried out in a Dutch family with Nance-Horan (NH) syndrome. Close linkage without recombination between NH and the Xp loci DXS207, DXS43, and DXS365 (zmax = 3.23) was observed. Multipoint linkage analysis and the analysis of recombinations in multiple informative meioses suggest the genetic order Xcen-DMD (exon 49)-DXS451-(NH, DXS207, DXS365, DXS43)-(STS, DXF30)-Xpter. These data refine the localization of the NH locus on the distal Xp",

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doi = "10.1006/geno.1994.1248",

language = "English",

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journal = "Genomics",

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T1 - Nance-Horan syndrome: linkage analysis in a family from The Netherlands

AU - Bergen, A. A.

AU - ten Brink, J.

AU - Schuurman, E. J.

AU - Bleeker-Wagemakers, E. M.

PY - 1994

Y1 - 1994

N2 - Linkage analysis was carried out in a Dutch family with Nance-Horan (NH) syndrome. Close linkage without recombination between NH and the Xp loci DXS207, DXS43, and DXS365 (zmax = 3.23) was observed. Multipoint linkage analysis and the analysis of recombinations in multiple informative meioses suggest the genetic order Xcen-DMD (exon 49)-DXS451-(NH, DXS207, DXS365, DXS43)-(STS, DXF30)-Xpter. These data refine the localization of the NH locus on the distal Xp

AB - Linkage analysis was carried out in a Dutch family with Nance-Horan (NH) syndrome. Close linkage without recombination between NH and the Xp loci DXS207, DXS43, and DXS365 (zmax = 3.23) was observed. Multipoint linkage analysis and the analysis of recombinations in multiple informative meioses suggest the genetic order Xcen-DMD (exon 49)-DXS451-(NH, DXS207, DXS365, DXS43)-(STS, DXF30)-Xpter. These data refine the localization of the NH locus on the distal Xp

U2 - 10.1006/geno.1994.1248

DO - 10.1006/geno.1994.1248

M3 - Comment/Letter to the editor

C2 - 8088793

SN - 0888-7543

VL - 21

SP - 238

EP - 240

JO - Genomics

JF - Genomics

IS - 1

ER -

Nance-Horan syndrome: linkage analysis in a family from The Netherlands

Abstract

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