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Multiscale Analysis of Morphogenesis

  • C. C. Antonovici
  • , S. E. M. Boas
  • , E. G. Rens
  • , H. Tahir
  • , R. M. H. Merks
  • Leiden University
  • Centrum voor Wiskunde en Informatica

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Abstract

How does the genetic information encoded in the DNA direct the growth and form of multicellular organisms? The genome directs a cell’s biophysical properties and its response to signals from adjacent cells. To analyze how these cell behaviors drive embryogenesis, insights into the collective behavior of multicellular aggregates is crucial. This article describes computational approaches to the study of collective cell behavior. Four examples (cell sorting, angiogenesis, somitogenesis, and root development) illustrate how computational insights into collective cell behavior are incorporated into experimental studies to unravel the mechanisms of development.
Original languageEnglish
Title of host publicationEncyclopedia of Cell Biology: Volume 1-6, Second Edition
PublisherElsevier
Pages322-335
Volume6
ISBN (Electronic)9780128216248
DOIs
Publication statusPublished - 1 Jan 2022

Publication series

NameEncyclopedia of Cell Biology: Volume 1-6, Second Edition

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