Multiple BCL2 mutations cooccurring with Gly101Val emerge in chronic lymphocytic leukemia progression on venetoclax

Piers Blombery; Ella R. Thompson; Tamia Nguyen; Richard W. Birkinshaw; Jia Nan Gong; Xiangting Chen; Michelle McBean; Rachel Thijssen; Thomas Conway; Mary Ann Anderson; John F. Seymour; David A. Westerman; Peter E. Czabotar; David C.S. Huang; Andrew W. Roberts

doi:10.1182/BLOOD.2019004205

Multiple BCL2 mutations cooccurring with Gly101Val emerge in chronic lymphocytic leukemia progression on venetoclax

Piers Blombery^*
, Ella R. Thompson
, Tamia Nguyen
, Richard W. Birkinshaw
, Jia Nan Gong
, Xiangting Chen
, Michelle McBean
, Rachel Thijssen
, Thomas Conway
, Mary Ann Anderson
, John F. Seymour
, David A. Westerman
, Peter E. Czabotar
, David C.S. Huang
, Andrew W. Roberts

^*Corresponding author for this work

Peter Maccallum Cancer Centre

Research output: Contribution to journal › Article › Academic › peer-review

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Original language	English
Pages (from-to)	773-777
Number of pages	5
Journal	Blood
Volume	135
Issue number	10
DOIs	https://doi.org/10.1182/BLOOD.2019004205
Publication status	Published - 5 Mar 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Lymphoid Neoplasia

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10.1182/BLOOD.2019004205

Multiple-bcl2-mutations-cooccurring-with-gly101val-emerge-in-chronic-lymphocytic-leukemia-progression-on-venetoclax.pdfFinal published version, 842 KBLicence: CC BY

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Blombery, P., Thompson, E. R., Nguyen, T., Birkinshaw, R. W., Gong, J. N., Chen, X., McBean, M., Thijssen, R., Conway, T., Anderson, M. A., Seymour, J. F., Westerman, D. A., Czabotar, P. E., Huang, D. C. S., & Roberts, A. W. (2020). Multiple BCL2 mutations cooccurring with Gly101Val emerge in chronic lymphocytic leukemia progression on venetoclax. Blood, 135(10), 773-777. https://doi.org/10.1182/BLOOD.2019004205

@article{b98840ec841f42969413ecfe33e3caff,

title = "Multiple BCL2 mutations cooccurring with Gly101Val emerge in chronic lymphocytic leukemia progression on venetoclax",

keywords = "Lymphoid Neoplasia",

author = "Piers Blombery and Thompson, \{Ella R.\} and Tamia Nguyen and Birkinshaw, \{Richard W.\} and Gong, \{Jia Nan\} and Xiangting Chen and Michelle McBean and Rachel Thijssen and Thomas Conway and Anderson, \{Mary Ann\} and Seymour, \{John F.\} and Westerman, \{David A.\} and Czabotar, \{Peter E.\} and Huang, \{David C.S.\} and Roberts, \{Andrew W.\}",

note = "Funding Information: The authors are grateful to the patients who enrolled on the venetoclax clinical trials, and for assistance from Naomi Sprigg with collection and curation of samples. This research was supported by grants from the Snowdome Foundation (P.B. and M.A.A.), Vision Super and the Wilson Centre for Lymphoma Genomics (P.B. and D.A.W.), the Leukemia and Lymphoma Acknowledgments Society (fellowship 5467-18 [R.T.], SCOR 7015-18 [D.C.S.H. and A.W.R.]), the National Health and Medical Research Council of Australia (fellowships 1079700 [P.E.C.], 1043149 [D.C.S.H], 1113577 (A.W.R.). This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government National Health and Medical Research Council Independent Research Institute Infrastructure Support Scheme.",

year = "2020",

month = mar,

day = "5",

doi = "10.1182/BLOOD.2019004205",

language = "English",

volume = "135",

pages = "773--777",

journal = "Blood",

issn = "0006-4971",

publisher = "American Society of Hematology",

number = "10",

}

Blombery, P, Thompson, ER, Nguyen, T, Birkinshaw, RW, Gong, JN, Chen, X, McBean, M, Thijssen, R, Conway, T, Anderson, MA, Seymour, JF, Westerman, DA, Czabotar, PE, Huang, DCS & Roberts, AW 2020, 'Multiple BCL2 mutations cooccurring with Gly101Val emerge in chronic lymphocytic leukemia progression on venetoclax', Blood, vol. 135, no. 10, pp. 773-777. https://doi.org/10.1182/BLOOD.2019004205

TY - JOUR

T1 - Multiple BCL2 mutations cooccurring with Gly101Val emerge in chronic lymphocytic leukemia progression on venetoclax

AU - Blombery, Piers

AU - Thompson, Ella R.

AU - Nguyen, Tamia

AU - Birkinshaw, Richard W.

AU - Gong, Jia Nan

AU - Chen, Xiangting

AU - McBean, Michelle

AU - Thijssen, Rachel

AU - Conway, Thomas

AU - Anderson, Mary Ann

AU - Seymour, John F.

AU - Westerman, David A.

AU - Czabotar, Peter E.

AU - Huang, David C.S.

AU - Roberts, Andrew W.

N1 - Funding Information: The authors are grateful to the patients who enrolled on the venetoclax clinical trials, and for assistance from Naomi Sprigg with collection and curation of samples. This research was supported by grants from the Snowdome Foundation (P.B. and M.A.A.), Vision Super and the Wilson Centre for Lymphoma Genomics (P.B. and D.A.W.), the Leukemia and Lymphoma Acknowledgments Society (fellowship 5467-18 [R.T.], SCOR 7015-18 [D.C.S.H. and A.W.R.]), the National Health and Medical Research Council of Australia (fellowships 1079700 [P.E.C.], 1043149 [D.C.S.H], 1113577 (A.W.R.). This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government National Health and Medical Research Council Independent Research Institute Infrastructure Support Scheme.

PY - 2020/3/5

Y1 - 2020/3/5

KW - Lymphoid Neoplasia

UR - https://www.scopus.com/pages/publications/85081944884

U2 - 10.1182/BLOOD.2019004205

DO - 10.1182/BLOOD.2019004205

M3 - Article

C2 - 31951646

SN - 0006-4971

VL - 135

SP - 773

EP - 777

JO - Blood

JF - Blood

IS - 10

ER -

Multiple BCL2 mutations cooccurring with Gly101Val emerge in chronic lymphocytic leukemia progression on venetoclax

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Keywords

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