TY - JOUR
T1 - Multimodal imaging of structural damage and inflammation in psoriatic arthritis
T2 - a comparison of DMARD-naive and DMARD-failure patients
AU - Renkli, Nağme Ö.
AU - Kleinrensink, Nienke J.
AU - Spierings, Julia
AU - Mastbergen, Simon
AU - Vonkeman, Harald E.
AU - Mooij, Shasti C.
AU - Schipper, Lydia G.
AU - Herman, Amin
AU - ten Katen, Iris
AU - Nap, Frank J.
AU - Hol, Marjolein E.
AU - de Jong, Pim A.
AU - Jansen, Mylène P.
AU - Foppen, Wouter
AU - Bhansing, Kavish J.
AU - van Bijnen, Sandra T. A.
AU - Bisoendial, Radjesh J.
AU - Comarniceanu, Antoaneta C.
AU - Geurts—van Bon, Lenny
AU - Jahangier, Z. Nazira
AU - Jansen, Tim L. T. A.
AU - Kok, Marc R.
AU - van Kuijk, Arno W. R.
AU - Leijten, Emmerik F. A.
AU - van Tubergen, Astrid M.
AU - Vreugdenhil, Simone A.
AU - the TOFA-PREDICT Author Group
AU - Wijngaarden, Siska
N1 - Publisher Copyright:
© The Author(s) 2024. Published by Oxford University Press on behalf of the British Society for Rheumatology.
PY - 2025/4/1
Y1 - 2025/4/1
N2 - Objectives: To compare inflammatory and structural differences in active PsA between DMARD-naive and DMARD-failure patients using diverse imaging approaches for future analyses. Additionally, to explore the influence of patient characteristics (clinical and demographic variables) on imaging findings. Methods: Of the 80 patients included from the first cohort of the ongoing multicentre TOFA-PREDICT trial, 40 were DMARD-naive and 40 were DMARD-failure (csDMARD failure; one prior bDMARD excluding etanercept was allowed), all meeting classification criteria for PsA with a minimum disease duration of eight weeks. Baseline conventional radiographs of hands and feet, MRIs of both ankles, and whole-body [18F]-fluorodeoxyglucose PET/CT (18F-FDG PET/CT) were evaluated for inflammatory and structural imaging parameters, including Sharp-van der Heijde (SHS), Heel Enthesitis Magnetic Resonance Imaging Scoring System (HEMRIS) and Deauville synovitis scoring. Differences between groups and the influence of patient characteristics were examined with multiple linear regression. Results: At baseline, patient characteristics were similar between groups. Imaging parameters showed limited inflammation and structural damage. Inflammatory imaging parameters were not significantly different (P > 0.200). Among structural parameters, only HEMRIS Achilles tendon structural damage was significantly different (P ¼ 0.024, R2 ¼ 0.071) and SHS Joint Space Narrowing was not statistically significant (P ¼ 0.050, R2 ¼ 0.048) with higher values for both in DMARD failures. After correction of patient characteristics, these differences in imaging disappeared (both P > 0.600). Conclusion: At baseline, PsA patient groups were comparable concerning structural and inflammatory imaging parameters, especially after correcting for patient characteristics. Thus, DMARD-naive and DMARD-failure patient groups may be combined in future PsA progression and treatment decision studies.
AB - Objectives: To compare inflammatory and structural differences in active PsA between DMARD-naive and DMARD-failure patients using diverse imaging approaches for future analyses. Additionally, to explore the influence of patient characteristics (clinical and demographic variables) on imaging findings. Methods: Of the 80 patients included from the first cohort of the ongoing multicentre TOFA-PREDICT trial, 40 were DMARD-naive and 40 were DMARD-failure (csDMARD failure; one prior bDMARD excluding etanercept was allowed), all meeting classification criteria for PsA with a minimum disease duration of eight weeks. Baseline conventional radiographs of hands and feet, MRIs of both ankles, and whole-body [18F]-fluorodeoxyglucose PET/CT (18F-FDG PET/CT) were evaluated for inflammatory and structural imaging parameters, including Sharp-van der Heijde (SHS), Heel Enthesitis Magnetic Resonance Imaging Scoring System (HEMRIS) and Deauville synovitis scoring. Differences between groups and the influence of patient characteristics were examined with multiple linear regression. Results: At baseline, patient characteristics were similar between groups. Imaging parameters showed limited inflammation and structural damage. Inflammatory imaging parameters were not significantly different (P > 0.200). Among structural parameters, only HEMRIS Achilles tendon structural damage was significantly different (P ¼ 0.024, R2 ¼ 0.071) and SHS Joint Space Narrowing was not statistically significant (P ¼ 0.050, R2 ¼ 0.048) with higher values for both in DMARD failures. After correction of patient characteristics, these differences in imaging disappeared (both P > 0.600). Conclusion: At baseline, PsA patient groups were comparable concerning structural and inflammatory imaging parameters, especially after correcting for patient characteristics. Thus, DMARD-naive and DMARD-failure patient groups may be combined in future PsA progression and treatment decision studies.
KW - HEMRIS
KW - MRI
KW - PET/CT
KW - PsA
KW - conventional radiographs
KW - imaging
KW - psoriatic arthritis
UR - https://www.scopus.com/pages/publications/105001998314
U2 - 10.1093/rheumatology/keae450
DO - 10.1093/rheumatology/keae450
M3 - Article
C2 - 39153007
SN - 1745-8382
VL - 64
SP - 1760
EP - 1769
JO - Nature Clinical Practice Rheumatology
JF - Nature Clinical Practice Rheumatology
IS - 4
ER -