TY - JOUR
T1 - MRI data-driven clustering reveals different subtypes of Dementia with Lewy bodies
AU - Inguanzo, Anna
AU - Poulakis, Konstantinos
AU - Mohanty, Rosaleena
AU - Schwarz, Christopher G.
AU - Przybelski, Scott A.
AU - Diaz-Galvan, Patricia
AU - Lowe, Val J.
AU - Boeve, Bradley F.
AU - Lemstra, Afina W.
AU - van de Beek, Marleen
AU - van der Flier, Wiesje
AU - Barkhof, Frederik
AU - Blanc, Frederic
AU - Loureiro de Sousa, Paulo
AU - Philippi, Nathalie
AU - Cretin, Benjamin
AU - Demuynck, Catherine
AU - Nedelska, Zuzana
AU - Hort, Jakub
AU - Segura, Barbara
AU - Junque, Carme
AU - Oppedal, Ketil
AU - Aarsland, Dag
AU - Westman, Eric
AU - Kantarci, Kejal
AU - Ferreira, Daniel
N1 - Funding Information:
This work was supported by the National Institutes of Health (U01-NS100620, P50-AG016574, U01-AG006786, R37-AG011378, R01-AG041851, R01-AG040042, C06-RR018898 and R01-NS080820), Foundation Dr. Corinne Schuler, the Mangurian Foundation for Lewy Body Research, the Elsie and Marvin Dekelboum Family Foundation, the Little Family Foundation, the Robert H. and Clarice Smith and Abigail Van Buren Alzheimer’s Disease Research Program, the Western Norway Regional Health Authority, the Swedish Foundation for Strategic Research (SSF), the Swedish Research Council (VR), Karolinska Institutet travel grants, Center for Innovative Medicine (CIMED), the Swedish Brain funding (Hjärnfonden), the Swedish Alzheimer’s funding (Alzheimerfonden), ALF Medicine, the Swedish Dementia funding (Demensförbundet), the Foundation for Geriatric Diseases at Karolinska Institutet, and the Projet Hospitalier de Recherche Clinique (PHRC, IDCRB 2012-A00992-41) and Fondation Université de Strasbourg. Z. Nedelska is supported by The Grant Agency of Charles University (grant PRIMUS 22/MED/011). The sponsors played no role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the article for publication.
Publisher Copyright:
© 2023, The Author(s).
PY - 2023/12/1
Y1 - 2023/12/1
N2 - Dementia with Lewy bodies (DLB) is a neurodegenerative disorder with a wide heterogeneity of symptoms, which suggests the existence of different subtypes. We used data-driven analysis of magnetic resonance imaging (MRI) data to investigate DLB subtypes. We included 165 DLB from the Mayo Clinic and 3 centers from the European DLB consortium and performed a hierarchical cluster analysis to identify subtypes based on gray matter (GM) volumes. To characterize the subtypes, we used demographic and clinical data, as well as β-amyloid, tau, and cerebrovascular biomarkers at baseline, and cognitive decline over three years. We identified 3 subtypes: an older subtype with reduced cortical GM volumes, worse cognition, and faster cognitive decline (n = 49, 30%); a subtype with low GM volumes in fronto-occipital regions (n = 76, 46%); and a subtype of younger patients with the highest cortical GM volumes, proportionally lower GM volumes in basal ganglia and the highest frequency of cognitive fluctuations (n = 40, 24%). This study shows the existence of MRI subtypes in DLB, which may have implications for clinical workout, research, and therapeutic decisions.
AB - Dementia with Lewy bodies (DLB) is a neurodegenerative disorder with a wide heterogeneity of symptoms, which suggests the existence of different subtypes. We used data-driven analysis of magnetic resonance imaging (MRI) data to investigate DLB subtypes. We included 165 DLB from the Mayo Clinic and 3 centers from the European DLB consortium and performed a hierarchical cluster analysis to identify subtypes based on gray matter (GM) volumes. To characterize the subtypes, we used demographic and clinical data, as well as β-amyloid, tau, and cerebrovascular biomarkers at baseline, and cognitive decline over three years. We identified 3 subtypes: an older subtype with reduced cortical GM volumes, worse cognition, and faster cognitive decline (n = 49, 30%); a subtype with low GM volumes in fronto-occipital regions (n = 76, 46%); and a subtype of younger patients with the highest cortical GM volumes, proportionally lower GM volumes in basal ganglia and the highest frequency of cognitive fluctuations (n = 40, 24%). This study shows the existence of MRI subtypes in DLB, which may have implications for clinical workout, research, and therapeutic decisions.
UR - https://www.scopus.com/pages/publications/85146749635
U2 - 10.1038/s41531-023-00448-6
DO - 10.1038/s41531-023-00448-6
M3 - Article
C2 - 36670121
SN - 2373-8057
VL - 9
JO - npj Parkinson's Disease
JF - npj Parkinson's Disease
IS - 1
M1 - 5
ER -