Monocyte chemoattractant protein 1 does not contribute to protective immunity against pneumococcal pneumonia

Mark C. Dessing; Alex F. de Vos; Sandrine Florquin; Tom van der Poll

doi:10.1128/IAI.00977-06

Monocyte chemoattractant protein 1 does not contribute to protective immunity against pneumococcal pneumonia

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

To determine the role of monocyte chemoattractant protein 1 (MCP-1) during pneumococcal pneumonia, MCP-1 knockout and wild-type mice were infected with Streptococcus pneumoniae. Pulmonary MCP-1 levels were strongly correlated to bacterial loads in wild-type mice. However, MCP-1 knockout and wild-type mice were indistinguishable with respect to bacterial growth, inflammatory responses, and lethality

Original language	English
Pages (from-to)	7021-7023
Journal	Infection and immunity
Volume	74
Issue number	12
DOIs	https://doi.org/10.1128/IAI.00977-06
Publication status	Published - 2006

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title = "Monocyte chemoattractant protein 1 does not contribute to protective immunity against pneumococcal pneumonia",

abstract = "To determine the role of monocyte chemoattractant protein 1 (MCP-1) during pneumococcal pneumonia, MCP-1 knockout and wild-type mice were infected with Streptococcus pneumoniae. Pulmonary MCP-1 levels were strongly correlated to bacterial loads in wild-type mice. However, MCP-1 knockout and wild-type mice were indistinguishable with respect to bacterial growth, inflammatory responses, and lethality",

author = "Dessing, \{Mark C.\} and \{de Vos\}, \{Alex F.\} and Sandrine Florquin and \{van der Poll\}, Tom",

year = "2006",

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language = "English",

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publisher = "American Society for Microbiology",

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AU - Dessing, Mark C.

AU - de Vos, Alex F.

AU - Florquin, Sandrine

AU - van der Poll, Tom

PY - 2006

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N2 - To determine the role of monocyte chemoattractant protein 1 (MCP-1) during pneumococcal pneumonia, MCP-1 knockout and wild-type mice were infected with Streptococcus pneumoniae. Pulmonary MCP-1 levels were strongly correlated to bacterial loads in wild-type mice. However, MCP-1 knockout and wild-type mice were indistinguishable with respect to bacterial growth, inflammatory responses, and lethality

AB - To determine the role of monocyte chemoattractant protein 1 (MCP-1) during pneumococcal pneumonia, MCP-1 knockout and wild-type mice were infected with Streptococcus pneumoniae. Pulmonary MCP-1 levels were strongly correlated to bacterial loads in wild-type mice. However, MCP-1 knockout and wild-type mice were indistinguishable with respect to bacterial growth, inflammatory responses, and lethality

U2 - 10.1128/IAI.00977-06

DO - 10.1128/IAI.00977-06

M3 - Article

C2 - 16982835

SN - 0019-9567

VL - 74

SP - 7021

EP - 7023

JO - Infection and immunity

JF - Infection and immunity

IS - 12

ER -

Monocyte chemoattractant protein 1 does not contribute to protective immunity against pneumococcal pneumonia

Abstract

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