Microvascular dysfunction in obesity: A potential mechanism in the pathogenesis of obesity-associated insulin resistance and hypertension

Amy M. Jonk; Alfons J.H.M. Houben; Renate T. De Jongh; Erik H. Serné; Nicoloaas C. Schaper; Coen D.A. Stehouwer

doi:10.1152/physiol.00012.2007

Microvascular dysfunction in obesity: A potential mechanism in the pathogenesis of obesity-associated insulin resistance and hypertension

Amy M. Jonk^*
, Alfons J.H.M. Houben
, Renate T. De Jongh
, Erik H. Serné
, Nicoloaas C. Schaper
, Coen D.A. Stehouwer

^*Corresponding author for this work

Maastricht University

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

Obesity is an important risk factor for insulin resistance and hypertension and plays a central role in the metabolic syndrome. Insight into the pathophysiology of this syndrome may lead to new treatments. This paper has reviewed the evidence for an important role for the microcirculation as a possible link between obesity, insulin resistance and hypertension.

Original language	English
Pages (from-to)	252-260
Number of pages	9
Journal	Physiology
Volume	22
Issue number	4
DOIs	https://doi.org/10.1152/physiol.00012.2007
Publication status	Published - 1 Aug 2007

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SDG 3 Good Health and Well-being

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10.1152/physiol.00012.2007

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title = "Microvascular dysfunction in obesity: A potential mechanism in the pathogenesis of obesity-associated insulin resistance and hypertension",

abstract = "Obesity is an important risk factor for insulin resistance and hypertension and plays a central role in the metabolic syndrome. Insight into the pathophysiology of this syndrome may lead to new treatments. This paper has reviewed the evidence for an important role for the microcirculation as a possible link between obesity, insulin resistance and hypertension.",

author = "Jonk, \{Amy M.\} and Houben, \{Alfons J.H.M.\} and \{De Jongh\}, \{Renate T.\} and Sern{\'e}, \{Erik H.\} and Schaper, \{Nicoloaas C.\} and Stehouwer, \{Coen D.A.\}",

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doi = "10.1152/physiol.00012.2007",

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T2 - A potential mechanism in the pathogenesis of obesity-associated insulin resistance and hypertension

AU - Jonk, Amy M.

AU - Houben, Alfons J.H.M.

AU - De Jongh, Renate T.

AU - Serné, Erik H.

AU - Schaper, Nicoloaas C.

AU - Stehouwer, Coen D.A.

PY - 2007/8/1

Y1 - 2007/8/1

N2 - Obesity is an important risk factor for insulin resistance and hypertension and plays a central role in the metabolic syndrome. Insight into the pathophysiology of this syndrome may lead to new treatments. This paper has reviewed the evidence for an important role for the microcirculation as a possible link between obesity, insulin resistance and hypertension.

AB - Obesity is an important risk factor for insulin resistance and hypertension and plays a central role in the metabolic syndrome. Insight into the pathophysiology of this syndrome may lead to new treatments. This paper has reviewed the evidence for an important role for the microcirculation as a possible link between obesity, insulin resistance and hypertension.

UR - https://www.scopus.com/pages/publications/34548210862

U2 - 10.1152/physiol.00012.2007

DO - 10.1152/physiol.00012.2007

M3 - Review article

C2 - 17699878

SN - 1548-9213

VL - 22

SP - 252

EP - 260

JO - Physiology

JF - Physiology

IS - 4

ER -

Microvascular dysfunction in obesity: A potential mechanism in the pathogenesis of obesity-associated insulin resistance and hypertension

Abstract

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