MEIS homeobox genes in neuroblastoma

Dirk Geerts; Ingrid Revet; Gerda Jorritsma; Nathalie Schilderink; Rogier Versteeg

doi:10.1016/j.canlet.2005.01.047

MEIS homeobox genes in neuroblastoma

Dirk Geerts
, Ingrid Revet
, Gerda Jorritsma
, Nathalie Schilderink
, Rogier Versteeg

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

The common pediatric tumor neuroblastoma originates from primitive neural crest-derived precursor cells of the peripheral nervous system. Neuroblastoma especially affects very young children, and can already be present at birth. Its early onset and cellular origin predict the involvement of developmental control genes in neuroblastoma etiology. These genes are indispensable for the tight regulation of normal embryonic development but as a consequence cause cancer and congenital diseases upon mutation or aberrant expression. To date however, the connotation of these genes in neuroblastoma pathogenesis is scant. This review recapitulates data on the MEIS homeobox control genes in cancer and focuses on neuroblastoma. (C) 2005 Elsevier Ireland Ltd. All rights reserved

Original language	English
Pages (from-to)	43-50
Number of pages	8
Journal	Cancer letters
Volume	228
Issue number	1-2
DOIs	https://doi.org/10.1016/j.canlet.2005.01.047
Publication status	Published - 18 Oct 2005

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Genes, Homeobox
Humans
Mutation
Neuroblastoma/genetics

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10.1016/j.canlet.2005.01.047

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title = "MEIS homeobox genes in neuroblastoma",

abstract = "The common pediatric tumor neuroblastoma originates from primitive neural crest-derived precursor cells of the peripheral nervous system. Neuroblastoma especially affects very young children, and can already be present at birth. Its early onset and cellular origin predict the involvement of developmental control genes in neuroblastoma etiology. These genes are indispensable for the tight regulation of normal embryonic development but as a consequence cause cancer and congenital diseases upon mutation or aberrant expression. To date however, the connotation of these genes in neuroblastoma pathogenesis is scant. This review recapitulates data on the MEIS homeobox control genes in cancer and focuses on neuroblastoma. (C) 2005 Elsevier Ireland Ltd. All rights reserved",

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T1 - MEIS homeobox genes in neuroblastoma

AU - Geerts, Dirk

AU - Revet, Ingrid

AU - Jorritsma, Gerda

AU - Schilderink, Nathalie

AU - Versteeg, Rogier

PY - 2005/10/18

Y1 - 2005/10/18

N2 - The common pediatric tumor neuroblastoma originates from primitive neural crest-derived precursor cells of the peripheral nervous system. Neuroblastoma especially affects very young children, and can already be present at birth. Its early onset and cellular origin predict the involvement of developmental control genes in neuroblastoma etiology. These genes are indispensable for the tight regulation of normal embryonic development but as a consequence cause cancer and congenital diseases upon mutation or aberrant expression. To date however, the connotation of these genes in neuroblastoma pathogenesis is scant. This review recapitulates data on the MEIS homeobox control genes in cancer and focuses on neuroblastoma. (C) 2005 Elsevier Ireland Ltd. All rights reserved

AB - The common pediatric tumor neuroblastoma originates from primitive neural crest-derived precursor cells of the peripheral nervous system. Neuroblastoma especially affects very young children, and can already be present at birth. Its early onset and cellular origin predict the involvement of developmental control genes in neuroblastoma etiology. These genes are indispensable for the tight regulation of normal embryonic development but as a consequence cause cancer and congenital diseases upon mutation or aberrant expression. To date however, the connotation of these genes in neuroblastoma pathogenesis is scant. This review recapitulates data on the MEIS homeobox control genes in cancer and focuses on neuroblastoma. (C) 2005 Elsevier Ireland Ltd. All rights reserved

KW - Genes, Homeobox

KW - Humans

KW - Mutation

KW - Neuroblastoma/genetics

U2 - 10.1016/j.canlet.2005.01.047

DO - 10.1016/j.canlet.2005.01.047

M3 - Review article

C2 - 15919149

SN - 0304-3835

VL - 228

SP - 43

EP - 50

JO - Cancer letters

JF - Cancer letters

IS - 1-2

ER -

MEIS homeobox genes in neuroblastoma

Abstract

UN SDGs

Keywords

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