TY - JOUR
T1 - Mapping subcortical brain alterations in 22q11.2 deletion syndrome: Effects of deletion size and convergence with idiopathic neuropsychiatric illness
AU - Ching, Christopher R. K.
AU - Gutman, Boris A.
AU - Sun, Daqiang
AU - Reina, Julio Villalon
AU - Ragothaman, Anjanibhargavi
AU - Isaev, Dmitry
AU - Zavaliangos-Petropulu, Artemis
AU - Lin, Amy
AU - Jonas, Rachel K.
AU - Kushan, Leila
AU - Pacheco-Hansen, Laura
AU - Vajdi, Ariana
AU - Forsyth, Jennifer K.
AU - Jalbrzikowski, Maria
AU - Bakker, Geor
AU - van Amelsvoort, Therese
AU - Antshel, Kevin M.
AU - Fremont, Wanda
AU - Kates, Wendy R.
AU - Campbell, Linda E.
AU - McCabe, Kathryn L.
AU - Craig, Michael C.
AU - Daly, Eileen
AU - Gudbrandsen, Maria
AU - Murphy, Clodagh M.
AU - Murphy, Declan G.
AU - Murphy, Kieran C.
AU - Fiksinski, Ania
AU - Koops, Sanne
AU - Vorstman, Jacob
AU - Crowley, T. Blaine
AU - Emanuel, Beverly S.
AU - Gur, Raquel E.
AU - McDonald-McGinn, Donna M.
AU - Roalf, David R.
AU - Ruparel, Kosha
AU - Schmitt, J. Eric
AU - Zackai, Elaine H.
AU - Durdle, Courtney A.
AU - Goodrich-Hunsaker, Naomi J.
AU - Simon, Tony J.
AU - Bassett, Anne S.
AU - Butcher, Nancy J.
AU - Chow, Eva W. C.
AU - Vila-Rodriguez, Fidel
AU - Cunningham, Adam
AU - Doherty, Joanne
AU - Linden, David E.
AU - Moss, Hayley
AU - Owen, Michael J.
AU - van den Bree, Marianne
AU - Crossley, Nicolas A.
AU - Repetto, Gabriela M.
AU - Thompson, Paul M.
AU - Bearden, Carrie E.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Objective: 22q11.2 deletion syndrome (22q11DS) is among the strongest known genetic risk factors for schizophrenia. Previous studies have reported variable alterations in subcortical brain structures in 22q11DS. To better characterize subcortical alterations in 22q11DS, including modulating effects of clinical and genetic heterogeneity, the authors studied a large multicenter neuroimaging cohort from the ENIGMA 22q11.2 Deletion Syndrome Working Group. Methods: Subcortical structures were measured using harmonized protocols for gross volume and subcortical shape morphometry in 533 individualswith 22q11DS and 330matched healthy control subjects (age range, 6-56 years; 49% female). Results: Compared with the control group, the 22q11DS group showed lower intracranial volume (ICV) and thalamus, putamen, hippocampus, and amygdala volumes and greater lateral ventricle, caudate, and accumbens volumes (Cohen's d values, 20.90 to 0.93). Shape analysis revealed complex differences in the 22q11DS group across all structures. The larger A-D deletion was associated with more extensive shape alterations compared with the smaller A-B deletion. Participants with 22q11DS with psychosis showed lower ICV and hippocampus, amygdala, and thalamus volumes (Cohen's d values, 20.91 to 0.53) compared with participants with 22q11DS without psychosis. Shape analysis revealed lower thickness and surface area across subregions of these structures. Compared with subcortical findings from other neuropsychiatric disorders studied by the ENIGMA consortium, significant convergence was observed between participants with 22q11DS with psychosis and participants with schizophrenia, bipolar disorder, major depressive disorder, and obsessive-compulsive disorder. Conclusions: In the largest neuroimaging study of 22q11DS to date, the authors found widespread alterations to subcortical brain structures, which were affected by deletion size and psychotic illness. Findings indicate significant overlap between 22q11DS-associated psychosis, idiopathic schizophrenia, and other severe neuropsychiatric illnesses.
AB - Objective: 22q11.2 deletion syndrome (22q11DS) is among the strongest known genetic risk factors for schizophrenia. Previous studies have reported variable alterations in subcortical brain structures in 22q11DS. To better characterize subcortical alterations in 22q11DS, including modulating effects of clinical and genetic heterogeneity, the authors studied a large multicenter neuroimaging cohort from the ENIGMA 22q11.2 Deletion Syndrome Working Group. Methods: Subcortical structures were measured using harmonized protocols for gross volume and subcortical shape morphometry in 533 individualswith 22q11DS and 330matched healthy control subjects (age range, 6-56 years; 49% female). Results: Compared with the control group, the 22q11DS group showed lower intracranial volume (ICV) and thalamus, putamen, hippocampus, and amygdala volumes and greater lateral ventricle, caudate, and accumbens volumes (Cohen's d values, 20.90 to 0.93). Shape analysis revealed complex differences in the 22q11DS group across all structures. The larger A-D deletion was associated with more extensive shape alterations compared with the smaller A-B deletion. Participants with 22q11DS with psychosis showed lower ICV and hippocampus, amygdala, and thalamus volumes (Cohen's d values, 20.91 to 0.53) compared with participants with 22q11DS without psychosis. Shape analysis revealed lower thickness and surface area across subregions of these structures. Compared with subcortical findings from other neuropsychiatric disorders studied by the ENIGMA consortium, significant convergence was observed between participants with 22q11DS with psychosis and participants with schizophrenia, bipolar disorder, major depressive disorder, and obsessive-compulsive disorder. Conclusions: In the largest neuroimaging study of 22q11DS to date, the authors found widespread alterations to subcortical brain structures, which were affected by deletion size and psychotic illness. Findings indicate significant overlap between 22q11DS-associated psychosis, idiopathic schizophrenia, and other severe neuropsychiatric illnesses.
UR - https://www.scopus.com/pages/publications/85085086221
U2 - 10.1176/appi.ajp.2019.19060583
DO - 10.1176/appi.ajp.2019.19060583
M3 - Article
C2 - 32046535
SN - 0002-953X
VL - 177
SP - 589
EP - 600
JO - American journal of psychiatry
JF - American journal of psychiatry
IS - 7
ER -
SDG 3 Good Health and Well-being