Manganese-induced Parkinsonism associated with methcathinone (Ephedrone) abuse

Rob M. A. de Bie; Richard M. Gladstone; Antonio P. Strafella; Ji-Hyun Ko; Anthony E. Lang

doi:10.1001/archneur.64.6.886

Manganese-induced Parkinsonism associated with methcathinone (Ephedrone) abuse

Rob M. A. de Bie
, Richard M. Gladstone
, Antonio P. Strafella
, Ji-Hyun Ko
, Anthony E. Lang

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Manganese intoxication may lead to a levodopa-resistant, akinetic-rigid syndrome. A new form of presumed manganese poisoning has been reported in drug-addicted persons from Russia, Ukraine, and Estonia who have intravenously injected self-prepared methcathinone hydrochloride (Ephedrone). PATIENT: A 36-year-old man from Azerbaijan with hepatitis C and only modest hepatic synthetic dysfunction developed rapid-onset, levodopa-resistant parkinsonism with profound hypophonia. CONCLUSION: Ephedronic encephalopathy outside the region of the former Soviet Union may become a more widespread public health problem as a result of global travel and the easy availability of the recipe for synthesis of methcathinone on the Internet

Original language	English
Pages (from-to)	886-889
Journal	Archives of neurology
Volume	64
Issue number	6
DOIs	https://doi.org/10.1001/archneur.64.6.886
Publication status	Published - 2007

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10.1001/archneur.64.6.886

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title = "Manganese-induced Parkinsonism associated with methcathinone (Ephedrone) abuse",

abstract = "BACKGROUND: Manganese intoxication may lead to a levodopa-resistant, akinetic-rigid syndrome. A new form of presumed manganese poisoning has been reported in drug-addicted persons from Russia, Ukraine, and Estonia who have intravenously injected self-prepared methcathinone hydrochloride (Ephedrone). PATIENT: A 36-year-old man from Azerbaijan with hepatitis C and only modest hepatic synthetic dysfunction developed rapid-onset, levodopa-resistant parkinsonism with profound hypophonia. CONCLUSION: Ephedronic encephalopathy outside the region of the former Soviet Union may become a more widespread public health problem as a result of global travel and the easy availability of the recipe for synthesis of methcathinone on the Internet",

author = "\{de Bie\}, \{Rob M. A.\} and Gladstone, \{Richard M.\} and Strafella, \{Antonio P.\} and Ji-Hyun Ko and Lang, \{Anthony E.\}",

year = "2007",

doi = "10.1001/archneur.64.6.886",

language = "English",

volume = "64",

pages = "886--889",

journal = "Archives of neurology",

issn = "0003-9942",

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T1 - Manganese-induced Parkinsonism associated with methcathinone (Ephedrone) abuse

AU - de Bie, Rob M. A.

AU - Gladstone, Richard M.

AU - Strafella, Antonio P.

AU - Ko, Ji-Hyun

AU - Lang, Anthony E.

PY - 2007

Y1 - 2007

N2 - BACKGROUND: Manganese intoxication may lead to a levodopa-resistant, akinetic-rigid syndrome. A new form of presumed manganese poisoning has been reported in drug-addicted persons from Russia, Ukraine, and Estonia who have intravenously injected self-prepared methcathinone hydrochloride (Ephedrone). PATIENT: A 36-year-old man from Azerbaijan with hepatitis C and only modest hepatic synthetic dysfunction developed rapid-onset, levodopa-resistant parkinsonism with profound hypophonia. CONCLUSION: Ephedronic encephalopathy outside the region of the former Soviet Union may become a more widespread public health problem as a result of global travel and the easy availability of the recipe for synthesis of methcathinone on the Internet

AB - BACKGROUND: Manganese intoxication may lead to a levodopa-resistant, akinetic-rigid syndrome. A new form of presumed manganese poisoning has been reported in drug-addicted persons from Russia, Ukraine, and Estonia who have intravenously injected self-prepared methcathinone hydrochloride (Ephedrone). PATIENT: A 36-year-old man from Azerbaijan with hepatitis C and only modest hepatic synthetic dysfunction developed rapid-onset, levodopa-resistant parkinsonism with profound hypophonia. CONCLUSION: Ephedronic encephalopathy outside the region of the former Soviet Union may become a more widespread public health problem as a result of global travel and the easy availability of the recipe for synthesis of methcathinone on the Internet

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DO - 10.1001/archneur.64.6.886

M3 - Article

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SN - 0003-9942

VL - 64

SP - 886

EP - 889

JO - Archives of neurology

JF - Archives of neurology

IS - 6

ER -

Manganese-induced Parkinsonism associated with methcathinone (Ephedrone) abuse

Abstract

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