Lower striatal dopamine D-2/3 receptor availability in obese compared with non-obese subjects

Barbara A. de Weijer; Elsmarieke van de Giessen; Therese A. van Amelsvoort; Erik Boot; Breg Braak; Ignace M. Janssen; Arnold van de Laar; Eric Fliers; Mireille J. Serlie; Jan Booij

doi:10.1186/2191-219X-1-37

Lower striatal dopamine D-2/3 receptor availability in obese compared with non-obese subjects

Barbara A. de Weijer
, Elsmarieke van de Giessen
, Therese A. van Amelsvoort
, Erik Boot
, Breg Braak
, Ignace M. Janssen
, Arnold van de Laar
, Eric Fliers
, Mireille J. Serlie
, Jan Booij

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Obesity is a result of a relative excess in energy intake over energy expenditure. These processes are controlled by genetic, environmental, psychological and biological factors. One of the factors involved in the regulation of food intake and satiety is dopaminergic signalling. A small number of studies have reported that striatal dopamine D-2/D-3 receptor [D2/3R] availability is lower in morbidly obese subjects. Methods: To confirm the role of D2/3R in obesity, we measured striatal D2/3R availability, using [I-123]IBZM SPECT, in 15 obese women and 15 non-obese controls. Results: Striatal D2/3R availability was 23% (p = 0.028) lower in obese compared with non-obese women. Conclusion: This study is an independent replication of the finding that severely obese subjects have lower striatal D2/3R availability. Our findings invigorate the evidence for lower striatal D2/3R availability in obesity and confirm the role of the striatal dopaminergic reward system in obesity

Original language	English
Pages (from-to)	37
Journal	EJNMMI research
Volume	1
Issue number	1
DOIs	https://doi.org/10.1186/2191-219X-1-37
Publication status	Published - 2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1186/2191-219X-1-37

Cite this

@article{f6caaab16b874bb8b344d29c14299bfb,

title = "Lower striatal dopamine D-2/3 receptor availability in obese compared with non-obese subjects",

abstract = "Background: Obesity is a result of a relative excess in energy intake over energy expenditure. These processes are controlled by genetic, environmental, psychological and biological factors. One of the factors involved in the regulation of food intake and satiety is dopaminergic signalling. A small number of studies have reported that striatal dopamine D-2/D-3 receptor [D2/3R] availability is lower in morbidly obese subjects. Methods: To confirm the role of D2/3R in obesity, we measured striatal D2/3R availability, using [I-123]IBZM SPECT, in 15 obese women and 15 non-obese controls. Results: Striatal D2/3R availability was 23\% (p = 0.028) lower in obese compared with non-obese women. Conclusion: This study is an independent replication of the finding that severely obese subjects have lower striatal D2/3R availability. Our findings invigorate the evidence for lower striatal D2/3R availability in obesity and confirm the role of the striatal dopaminergic reward system in obesity",

author = "\{de Weijer\}, \{Barbara A.\} and \{van de Giessen\}, Elsmarieke and \{van Amelsvoort\}, \{Therese A.\} and Erik Boot and Breg Braak and Janssen, \{Ignace M.\} and \{van de Laar\}, Arnold and Eric Fliers and Serlie, \{Mireille J.\} and Jan Booij",

year = "2011",

doi = "10.1186/2191-219X-1-37",

language = "English",

volume = "1",

pages = "37",

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TY - JOUR

T1 - Lower striatal dopamine D-2/3 receptor availability in obese compared with non-obese subjects

AU - de Weijer, Barbara A.

AU - van de Giessen, Elsmarieke

AU - van Amelsvoort, Therese A.

AU - Boot, Erik

AU - Braak, Breg

AU - Janssen, Ignace M.

AU - van de Laar, Arnold

AU - Fliers, Eric

AU - Serlie, Mireille J.

AU - Booij, Jan

PY - 2011

Y1 - 2011

N2 - Background: Obesity is a result of a relative excess in energy intake over energy expenditure. These processes are controlled by genetic, environmental, psychological and biological factors. One of the factors involved in the regulation of food intake and satiety is dopaminergic signalling. A small number of studies have reported that striatal dopamine D-2/D-3 receptor [D2/3R] availability is lower in morbidly obese subjects. Methods: To confirm the role of D2/3R in obesity, we measured striatal D2/3R availability, using [I-123]IBZM SPECT, in 15 obese women and 15 non-obese controls. Results: Striatal D2/3R availability was 23% (p = 0.028) lower in obese compared with non-obese women. Conclusion: This study is an independent replication of the finding that severely obese subjects have lower striatal D2/3R availability. Our findings invigorate the evidence for lower striatal D2/3R availability in obesity and confirm the role of the striatal dopaminergic reward system in obesity

AB - Background: Obesity is a result of a relative excess in energy intake over energy expenditure. These processes are controlled by genetic, environmental, psychological and biological factors. One of the factors involved in the regulation of food intake and satiety is dopaminergic signalling. A small number of studies have reported that striatal dopamine D-2/D-3 receptor [D2/3R] availability is lower in morbidly obese subjects. Methods: To confirm the role of D2/3R in obesity, we measured striatal D2/3R availability, using [I-123]IBZM SPECT, in 15 obese women and 15 non-obese controls. Results: Striatal D2/3R availability was 23% (p = 0.028) lower in obese compared with non-obese women. Conclusion: This study is an independent replication of the finding that severely obese subjects have lower striatal D2/3R availability. Our findings invigorate the evidence for lower striatal D2/3R availability in obesity and confirm the role of the striatal dopaminergic reward system in obesity

U2 - 10.1186/2191-219X-1-37

DO - 10.1186/2191-219X-1-37

M3 - Article

C2 - 22214469

SN - 2191-219X

VL - 1

SP - 37

JO - EJNMMI research

JF - EJNMMI research

IS - 1

ER -

Lower striatal dopamine D-2/3 receptor availability in obese compared with non-obese subjects

Abstract

UN SDGs

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