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Lower progression rate of end-stage renal disease in patients with peripheral arterial disease using statins or Angiotensin-converting enzyme inhibitors. Journal of the American Society of Nephrology : JASN

  • Harm H. H. Feringa
  • , Stefanos E. Karagiannis
  • , Michel Chonchol
  • , Radosav Vidakovic
  • , Peter G. Noordzij
  • , Abdou Elhendy
  • , Ron T. van Domburg
  • , Gijs Welten
  • , Olaf Schouten
  • , Jeroen J. Bax
  • , Tomas Berl
  • , Don Poldermans

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Patients with peripheral arterial disease (PAD) are at increased risk for ESRD and cardiovascular events. The primary objective was to assess the association between ankle-brachial index (ABI) values and renal outcome. The secondary objective was to evaluate whether statins and angiotensin-converting enzyme inhibitors (ACEI) are associated with improved renal and cardiovascular outcome in patients with PAD. In a prospective observational cohort study of 1940 consecutive patients with PAD, ABI was measured and chronic statin and ACEI therapy was noted at baseline. Serial creatinine concentrations were obtained at baseline, 6 mo, and every year after enrollment. End points were ESRD, all-cause mortality, and cardiac events during a median follow-up period of 8 yr. Baseline estimated GFR
Original languageEnglish
Pages (from-to)1872-1879
Number of pages8
JournalJournal of the American Society of Nephrology
Volume18
Issue number6
DOIs
Publication statusPublished - 2007

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • Aged
  • Female
  • Humans
  • Male
  • Middle Aged
  • Risk Factors
  • Prospective Studies
  • Kaplan-Meier Estimate
  • Multivariate Analysis
  • Follow-Up Studies
  • Angiotensin-Converting Enzyme Inhibitors/*therapeutic use
  • Disease Progression
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use
  • Kidney Failure, Chronic/*mortality/physiopathology
  • Peripheral Vascular Diseases/*drug therapy/*mortality
  • Prevalence

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