Loss of global DNA hypermethylation is prognostic in IDH-mutant and 1p/19q-codeleted oligodendrogliomas

Felix E. Hinz; Dennis Friedel; Franziska M. Ippen; Martin Sill; Andrey Korshunov; Leonille Schweizer; Daniel Schrimpf; Kirsten Göbel; Lukas S. Friedrich; Fuat K. Aras; Henri Bogumil; Rouzbeh Banan; Hildegard Dohmen; Till Acker; Sebastian Brandner; Simone Schmid; David Capper; Niklas Grassl; Henning B. Boldt; Pieter Wesseling; Sybren L. N. Maas; Juan P. Garces Martinez; Christine Stadelmann; Guido Reifenberger; Thomas Stehle; Alonso Barrantes-Freer; Tareq A. Juratli; Stefan Pusch; Daniel Haag; David E. Reuss; Christel Herold-Mende; Sandro Krieg; Wolfgang Wick; Nima Etminan; Michael Platten; Stefan M. Pfister; David T. W. Jones; Felix Sahm; Andreas von Deimling; Abigail K. Suwala

doi:10.1007/s00401-025-02963-7

Loss of global DNA hypermethylation is prognostic in IDH-mutant and 1p/19q-codeleted oligodendrogliomas

Felix E. Hinz
, Dennis Friedel
, Franziska M. Ippen
, Martin Sill
, Andrey Korshunov
, Leonille Schweizer
, Daniel Schrimpf
, Kirsten Göbel
, Lukas S. Friedrich
, Fuat K. Aras
, Henri Bogumil
, Rouzbeh Banan
, Hildegard Dohmen
, Till Acker
, Sebastian Brandner
, Simone Schmid
, David Capper
, Niklas Grassl
, Henning B. Boldt
, Pieter Wesseling

Sybren L. N. Maas, Juan P. Garces Martinez, Christine Stadelmann, Guido Reifenberger, Thomas Stehle, Alonso Barrantes-Freer, Tareq A. Juratli, Stefan Pusch, Daniel Haag, David E. Reuss, Christel Herold-Mende, Sandro Krieg, Wolfgang Wick, Nima Etminan, Michael Platten, Stefan M. Pfister, David T. W. Jones, Felix Sahm, Andreas von Deimling, Abigail K. Suwala^*

^*Corresponding author for this work

Heidelberg University
German Cancer Research Center
Hopp Children’s Cancer Center Heidelberg (KiTZ)
Goethe University Frankfurt
Frankfurt Cancer Institute (FCI)
Institute of Pathology Nordhessen
Justus Liebig University Giessen
University College London
Charité – Universitätsmedizin Berlin
University of Southern Denmark
Amsterdam UMC - University of Amsterdam
Leiden University
Erasmus University Rotterdam
University of Göttingen
Heinrich Heine University Düsseldorf
University of Cologne
Leipzig University
Technische Universität Dresden

Research output: Contribution to journal › Comment/Letter to the editor › Academic

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Original language	English
Article number	56
Journal	Acta Neuropathol.
Volume	150
Issue number	1
DOIs	https://doi.org/10.1007/s00401-025-02963-7
Publication status	Published - 1 Dec 2025

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Hinz, F. E., Friedel, D., Ippen, F. M., Sill, M., Korshunov, A., Schweizer, L., Schrimpf, D., Göbel, K., Friedrich, L. S., Aras, F. K., Bogumil, H., Banan, R., Dohmen, H., Acker, T., Brandner, S., Schmid, S., Capper, D., Grassl, N., Boldt, H. B., ... Suwala, A. K. (2025). Loss of global DNA hypermethylation is prognostic in IDH-mutant and 1p/19q-codeleted oligodendrogliomas. Acta Neuropathol., 150(1), Article 56. https://doi.org/10.1007/s00401-025-02963-7

@article{1f4a47ecc3a64904881693784e14aaec,

title = "Loss of global DNA hypermethylation is prognostic in IDH-mutant and 1p/19q-codeleted oligodendrogliomas",

author = "Hinz, \{Felix E.\} and Dennis Friedel and Ippen, \{Franziska M.\} and Martin Sill and Andrey Korshunov and Leonille Schweizer and Daniel Schrimpf and Kirsten G{\"o}bel and Friedrich, \{Lukas S.\} and Aras, \{Fuat K.\} and Henri Bogumil and Rouzbeh Banan and Hildegard Dohmen and Till Acker and Sebastian Brandner and Simone Schmid and David Capper and Niklas Grassl and Boldt, \{Henning B.\} and Pieter Wesseling and Maas, \{Sybren L. N.\} and Martinez, \{Juan P. Garces\} and Christine Stadelmann and Guido Reifenberger and Thomas Stehle and Alonso Barrantes-Freer and Juratli, \{Tareq A.\} and Stefan Pusch and Daniel Haag and Reuss, \{David E.\} and Christel Herold-Mende and Sandro Krieg and Wolfgang Wick and Nima Etminan and Michael Platten and Pfister, \{Stefan M.\} and Jones, \{David T. W.\} and Felix Sahm and \{von Deimling\}, Andreas and Suwala, \{Abigail K.\}",

year = "2025",

month = dec,

day = "1",

doi = "10.1007/s00401-025-02963-7",

language = "English",

volume = "150",

journal = "Acta Neuropathol.",

issn = "0001-6322",

publisher = "Springer Science and Business Media Deutschland GmbH",

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Hinz, FE, Friedel, D, Ippen, FM, Sill, M, Korshunov, A, Schweizer, L, Schrimpf, D, Göbel, K, Friedrich, LS, Aras, FK, Bogumil, H, Banan, R, Dohmen, H, Acker, T, Brandner, S, Schmid, S, Capper, D, Grassl, N, Boldt, HB, Wesseling, P, Maas, SLN, Martinez, JPG, Stadelmann, C, Reifenberger, G, Stehle, T, Barrantes-Freer, A, Juratli, TA, Pusch, S, Haag, D, Reuss, DE, Herold-Mende, C, Krieg, S, Wick, W, Etminan, N, Platten, M, Pfister, SM, Jones, DTW, Sahm, F, von Deimling, A & Suwala, AK 2025, 'Loss of global DNA hypermethylation is prognostic in IDH-mutant and 1p/19q-codeleted oligodendrogliomas', Acta Neuropathol., vol. 150, no. 1, 56. https://doi.org/10.1007/s00401-025-02963-7

TY - JOUR

T1 - Loss of global DNA hypermethylation is prognostic in IDH-mutant and 1p/19q-codeleted oligodendrogliomas

AU - Hinz, Felix E.

AU - Friedel, Dennis

AU - Ippen, Franziska M.

AU - Sill, Martin

AU - Korshunov, Andrey

AU - Schweizer, Leonille

AU - Schrimpf, Daniel

AU - Göbel, Kirsten

AU - Friedrich, Lukas S.

AU - Aras, Fuat K.

AU - Bogumil, Henri

AU - Banan, Rouzbeh

AU - Dohmen, Hildegard

AU - Acker, Till

AU - Brandner, Sebastian

AU - Schmid, Simone

AU - Capper, David

AU - Grassl, Niklas

AU - Boldt, Henning B.

AU - Wesseling, Pieter

AU - Maas, Sybren L. N.

AU - Martinez, Juan P. Garces

AU - Stadelmann, Christine

AU - Reifenberger, Guido

AU - Stehle, Thomas

AU - Barrantes-Freer, Alonso

AU - Juratli, Tareq A.

AU - Pusch, Stefan

AU - Haag, Daniel

AU - Reuss, David E.

AU - Herold-Mende, Christel

AU - Krieg, Sandro

AU - Wick, Wolfgang

AU - Etminan, Nima

AU - Platten, Michael

AU - Pfister, Stefan M.

AU - Jones, David T. W.

AU - Sahm, Felix

AU - von Deimling, Andreas

AU - Suwala, Abigail K.

PY - 2025/12/1

Y1 - 2025/12/1

UR - https://www.scopus.com/pages/publications/105023207052

U2 - 10.1007/s00401-025-02963-7

DO - 10.1007/s00401-025-02963-7

M3 - Comment/Letter to the editor

C2 - 41299137

SN - 0001-6322

VL - 150

JO - Acta Neuropathol.

JF - Acta Neuropathol.

IS - 1

M1 - 56

ER -

Loss of global DNA hypermethylation is prognostic in IDH-mutant and 1p/19q-codeleted oligodendrogliomas

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