Long-term clinical outcome of primary progressive MS: Predictive value of clinical and MRI data

J. Sastre-Garriga; G. T. Ingle; M. Rovaris; N. Téllez; B. Jasperse; D. R. Altmann; B. Benedetti; V. L. Stevenson; M. Cercignani; S. M. Leary; F. Barkhof; B. Brochet; V. Dousset; M. Filippi; X. Montalban; N. F. Kalkers; C. H. Polman; A. Rovira; D. H. Miller; Alan J. Thompson

doi:10.1212/01.wnl.0000173061.12776.1f

Long-term clinical outcome of primary progressive MS: Predictive value of clinical and MRI data

J. Sastre-Garriga
, G. T. Ingle
, M. Rovaris
, N. Téllez
, B. Jasperse
, D. R. Altmann
, B. Benedetti
, V. L. Stevenson
, M. Cercignani
, S. M. Leary
, F. Barkhof
, B. Brochet
, V. Dousset
, M. Filippi
, X. Montalban
, N. F. Kalkers
, C. H. Polman
, A. Rovira
, D. H. Miller
, Alan J. Thompson

University College London
From the Neuroimaging Research Unit, Division of Neuroscience (P.P.), and Neurology Unite (P.P.), IRCCS San Raffaele Scientific Institute, Milan, Italy; and Department of Anatomy and Neurosciences (M.M.S.), MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, the Netherlands
Hospital Vall d’Hebron
London School of Hygiene and Tropical Medicine
Université de Bordeaux

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

The authors sought to identify clinical and MRI predictors of outcome in primary progressive multiple sclerosis (PPMS). Clinical and MRI assessments were performed at baseline and 2 and 5 years (clinical only). At baseline, disease duration, expanded disability status scale (EDSS) and brain volume predicted outcome. Adding short-term change variables, baseline EDSS, changes in T2* lesion load and cord area, and number of new lesions were predictive. Clinical and MRI variables predict long-term outcome in PPMS. Copyright © 2005 by AAN Enterprises, Inc.

Original language	English
Pages (from-to)	633-635
Number of pages	3
Journal	Neurology
Volume	65
Issue number	4
DOIs	https://doi.org/10.1212/01.wnl.0000173061.12776.1f
Publication status	Published - 23 Aug 2005

Keywords

Atrophy/pathology
Brain/pathology
Central Nervous System/pathology
Cohort Studies
Data Collection
Diffusion Magnetic Resonance Imaging/standards
Disability Evaluation
Disease Progression
Humans
Longitudinal Studies
Magnetic Resonance Imaging/methods
Multiple Sclerosis, Chronic Progressive/diagnosis
Nerve Fibers, Myelinated/pathology
Neurologic Examination
Predictive Value of Tests
Prognosis
Prospective Studies
Spinal Cord/pathology
Time Factors

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Sastre-Garriga, J., Ingle, G. T., Rovaris, M., Téllez, N., Jasperse, B., Altmann, D. R., Benedetti, B., Stevenson, V. L., Cercignani, M., Leary, S. M., Barkhof, F., Brochet, B., Dousset, V., Filippi, M., Montalban, X., Kalkers, N. F., Polman, C. H., Rovira, A., Miller, D. H., & Thompson, A. J. (2005). Long-term clinical outcome of primary progressive MS: Predictive value of clinical and MRI data. Neurology, 65(4), 633-635. https://doi.org/10.1212/01.wnl.0000173061.12776.1f

@article{80cf0db6e19c4ddc88b3686f97bcceaa,

title = "Long-term clinical outcome of primary progressive MS: Predictive value of clinical and MRI data",

abstract = "The authors sought to identify clinical and MRI predictors of outcome in primary progressive multiple sclerosis (PPMS). Clinical and MRI assessments were performed at baseline and 2 and 5 years (clinical only). At baseline, disease duration, expanded disability status scale (EDSS) and brain volume predicted outcome. Adding short-term change variables, baseline EDSS, changes in T2* lesion load and cord area, and number of new lesions were predictive. Clinical and MRI variables predict long-term outcome in PPMS. Copyright {\textcopyright} 2005 by AAN Enterprises, Inc.",

keywords = "Atrophy/pathology, Brain/pathology, Central Nervous System/pathology, Cohort Studies, Data Collection, Diffusion Magnetic Resonance Imaging/standards, Disability Evaluation, Disease Progression, Humans, Longitudinal Studies, Magnetic Resonance Imaging/methods, Multiple Sclerosis, Chronic Progressive/diagnosis, Nerve Fibers, Myelinated/pathology, Neurologic Examination, Predictive Value of Tests, Prognosis, Prospective Studies, Spinal Cord/pathology, Time Factors",

author = "J. Sastre-Garriga and Ingle, \{G. T.\} and M. Rovaris and N. T{\'e}llez and B. Jasperse and Altmann, \{D. R.\} and B. Benedetti and Stevenson, \{V. L.\} and M. Cercignani and Leary, \{S. M.\} and F. Barkhof and B. Brochet and V. Dousset and M. Filippi and X. Montalban and Kalkers, \{N. F.\} and Polman, \{C. H.\} and A. Rovira and Miller, \{D. H.\} and Thompson, \{Alan J.\}",

year = "2005",

month = aug,

day = "23",

doi = "10.1212/01.wnl.0000173061.12776.1f",

language = "English",

volume = "65",

pages = "633--635",

journal = "Neurology",

issn = "0028-3878",

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}

Sastre-Garriga, J, Ingle, GT, Rovaris, M, Téllez, N, Jasperse, B, Altmann, DR, Benedetti, B, Stevenson, VL, Cercignani, M, Leary, SM, Barkhof, F, Brochet, B, Dousset, V, Filippi, M, Montalban, X, Kalkers, NF , Polman, CH, Rovira, A, Miller, DH & Thompson, AJ 2005, 'Long-term clinical outcome of primary progressive MS: Predictive value of clinical and MRI data', Neurology, vol. 65, no. 4, pp. 633-635. https://doi.org/10.1212/01.wnl.0000173061.12776.1f

TY - JOUR

T1 - Long-term clinical outcome of primary progressive MS

T2 - Predictive value of clinical and MRI data

AU - Sastre-Garriga, J.

AU - Ingle, G. T.

AU - Rovaris, M.

AU - Téllez, N.

AU - Jasperse, B.

AU - Altmann, D. R.

AU - Benedetti, B.

AU - Stevenson, V. L.

AU - Cercignani, M.

AU - Leary, S. M.

AU - Barkhof, F.

AU - Brochet, B.

AU - Dousset, V.

AU - Filippi, M.

AU - Montalban, X.

AU - Kalkers, N. F.

AU - Polman, C. H.

AU - Rovira, A.

AU - Miller, D. H.

AU - Thompson, Alan J.

PY - 2005/8/23

Y1 - 2005/8/23

N2 - The authors sought to identify clinical and MRI predictors of outcome in primary progressive multiple sclerosis (PPMS). Clinical and MRI assessments were performed at baseline and 2 and 5 years (clinical only). At baseline, disease duration, expanded disability status scale (EDSS) and brain volume predicted outcome. Adding short-term change variables, baseline EDSS, changes in T2* lesion load and cord area, and number of new lesions were predictive. Clinical and MRI variables predict long-term outcome in PPMS. Copyright © 2005 by AAN Enterprises, Inc.

AB - The authors sought to identify clinical and MRI predictors of outcome in primary progressive multiple sclerosis (PPMS). Clinical and MRI assessments were performed at baseline and 2 and 5 years (clinical only). At baseline, disease duration, expanded disability status scale (EDSS) and brain volume predicted outcome. Adding short-term change variables, baseline EDSS, changes in T2* lesion load and cord area, and number of new lesions were predictive. Clinical and MRI variables predict long-term outcome in PPMS. Copyright © 2005 by AAN Enterprises, Inc.

KW - Atrophy/pathology

KW - Brain/pathology

KW - Central Nervous System/pathology

KW - Cohort Studies

KW - Data Collection

KW - Diffusion Magnetic Resonance Imaging/standards

KW - Disability Evaluation

KW - Disease Progression

KW - Humans

KW - Longitudinal Studies

KW - Magnetic Resonance Imaging/methods

KW - Multiple Sclerosis, Chronic Progressive/diagnosis

KW - Nerve Fibers, Myelinated/pathology

KW - Neurologic Examination

KW - Predictive Value of Tests

KW - Prognosis

KW - Prospective Studies

KW - Spinal Cord/pathology

KW - Time Factors

UR - https://www.scopus.com/pages/publications/20444477614

UR - https://www.ncbi.nlm.nih.gov/pubmed/16116134

U2 - 10.1212/01.wnl.0000173061.12776.1f

DO - 10.1212/01.wnl.0000173061.12776.1f

M3 - Article

C2 - 16116134

SN - 0028-3878

VL - 65

SP - 633

EP - 635

JO - Neurology

JF - Neurology

IS - 4

ER -

Long-term clinical outcome of primary progressive MS: Predictive value of clinical and MRI data

Abstract

Keywords

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