Localization of the 17q breakpoint of a constitutional 1;17 translocation in a patient with neuroblastoma within a 25-kb segment located between the ACCN1 and TLK2 genes and near the distal breakpoints of two microdeletions in neurofibromatosis type 1 patients

Nadine van Roy; Jo Vandesompele; Geert Berx; Katrien Staes; Mireille van Gele; Els de Smet; Anne de Paepe; Geneviève Laureys; Pauline van der Drift; Rogier Versteeg; Frans van Roy; Frank Speleman

doi:10.1002/gcc.10034

Localization of the 17q breakpoint of a constitutional 1;17 translocation in a patient with neuroblastoma within a 25-kb segment located between the ACCN1 and TLK2 genes and near the distal breakpoints of two microdeletions in neurofibromatosis type 1 patients

Nadine van Roy
, Jo Vandesompele
, Geert Berx
, Katrien Staes
, Mireille van Gele
, Els de Smet
, Anne de Paepe
, Geneviève Laureys
, Pauline van der Drift
, Rogier Versteeg
, Frans van Roy
, Frank Speleman

Affiliatie UvA

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We have constructed a 1.4-Mb P1 artificial chromosome/bacterial artificial chromosome (PAC/BAC) contig spanning the 17q breakpoint of a constitutional translocation t(1;17)(p36.2;q11.2) in a patient with neuroblastoma. Three 17q breakpoint-overlapping cosmids were identified and sequenced. No coding sequences were found in the immediate proximity of the 17q breakpoint. The PAC/BAC contig covers the region between the proximally located ACCN1 gene and the distally located TLK2 gene and SCYA chemokine gene cluster. The observation that the 17q breakpoint region could not be detected in any of the screened yeast artificial chromosome libraries and the localization of the 17q breakpoint in the vicinity of the distal breakpoints of two microdeletions in patients with neurofibromatosis type 1 suggest that this chromosomal region is genetically unstable and prone to rearrangements

Original language	English
Pages (from-to)	113-120
Journal	Genes, chromosomes & cancer
Volume	35
Issue number	2
DOIs	https://doi.org/10.1002/gcc.10034
Publication status	Published - 2002

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1002/gcc.10034

Fingerprint

Dive into the research topics of 'Localization of the 17q breakpoint of a constitutional 1;17 translocation in a patient with neuroblastoma within a 25-kb segment located between the ACCN1 and TLK2 genes and near the distal breakpoints of two microdeletions in neurofibromatosis type 1 patients'. Together they form a unique fingerprint.

Cite this

van Roy, N., Vandesompele, J., Berx, G., Staes, K., van Gele, M., de Smet, E., de Paepe, A., Laureys, G., van der Drift, P., Versteeg, R., van Roy, F., & Speleman, F. (2002). Localization of the 17q breakpoint of a constitutional 1;17 translocation in a patient with neuroblastoma within a 25-kb segment located between the ACCN1 and TLK2 genes and near the distal breakpoints of two microdeletions in neurofibromatosis type 1 patients. Genes, chromosomes & cancer, 35(2), 113-120. https://doi.org/10.1002/gcc.10034

van Roy, Nadine ; Vandesompele, Jo ; Berx, Geert et al. / Localization of the 17q breakpoint of a constitutional 1;17 translocation in a patient with neuroblastoma within a 25-kb segment located between the ACCN1 and TLK2 genes and near the distal breakpoints of two microdeletions in neurofibromatosis type 1 patients. In: Genes, chromosomes & cancer. 2002 ; Vol. 35, No. 2. pp. 113-120.

@article{656959be2d6a4b65acde9e201c74f41b,

title = "Localization of the 17q breakpoint of a constitutional 1;17 translocation in a patient with neuroblastoma within a 25-kb segment located between the ACCN1 and TLK2 genes and near the distal breakpoints of two microdeletions in neurofibromatosis type 1 patients",

abstract = "We have constructed a 1.4-Mb P1 artificial chromosome/bacterial artificial chromosome (PAC/BAC) contig spanning the 17q breakpoint of a constitutional translocation t(1;17)(p36.2;q11.2) in a patient with neuroblastoma. Three 17q breakpoint-overlapping cosmids were identified and sequenced. No coding sequences were found in the immediate proximity of the 17q breakpoint. The PAC/BAC contig covers the region between the proximally located ACCN1 gene and the distally located TLK2 gene and SCYA chemokine gene cluster. The observation that the 17q breakpoint region could not be detected in any of the screened yeast artificial chromosome libraries and the localization of the 17q breakpoint in the vicinity of the distal breakpoints of two microdeletions in patients with neurofibromatosis type 1 suggest that this chromosomal region is genetically unstable and prone to rearrangements",

author = "\{van Roy\}, Nadine and Jo Vandesompele and Geert Berx and Katrien Staes and \{van Gele\}, Mireille and \{de Smet\}, Els and \{de Paepe\}, Anne and Genevi{\`e}ve Laureys and \{van der Drift\}, Pauline and Rogier Versteeg and \{van Roy\}, Frans and Frank Speleman",

year = "2002",

doi = "10.1002/gcc.10034",

language = "English",

volume = "35",

pages = "113--120",

journal = "Genes, chromosomes \& cancer",

issn = "1045-2257",

publisher = "Wiley-Liss Inc.",

number = "2",

}

van Roy, N, Vandesompele, J, Berx, G, Staes, K, van Gele, M, de Smet, E, de Paepe, A, Laureys, G, van der Drift, P, Versteeg, R, van Roy, F & Speleman, F 2002, 'Localization of the 17q breakpoint of a constitutional 1;17 translocation in a patient with neuroblastoma within a 25-kb segment located between the ACCN1 and TLK2 genes and near the distal breakpoints of two microdeletions in neurofibromatosis type 1 patients', Genes, chromosomes & cancer, vol. 35, no. 2, pp. 113-120. https://doi.org/10.1002/gcc.10034

Localization of the 17q breakpoint of a constitutional 1;17 translocation in a patient with neuroblastoma within a 25-kb segment located between the ACCN1 and TLK2 genes and near the distal breakpoints of two microdeletions in neurofibromatosis type 1 patients. / van Roy, Nadine; Vandesompele, Jo; Berx, Geert et al.
In: Genes, chromosomes & cancer, Vol. 35, No. 2, 2002, p. 113-120.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Localization of the 17q breakpoint of a constitutional 1;17 translocation in a patient with neuroblastoma within a 25-kb segment located between the ACCN1 and TLK2 genes and near the distal breakpoints of two microdeletions in neurofibromatosis type 1 patients

AU - van Roy, Nadine

AU - Vandesompele, Jo

AU - Berx, Geert

AU - Staes, Katrien

AU - van Gele, Mireille

AU - de Smet, Els

AU - de Paepe, Anne

AU - Laureys, Geneviève

AU - van der Drift, Pauline

AU - Versteeg, Rogier

AU - van Roy, Frans

AU - Speleman, Frank

PY - 2002

Y1 - 2002

N2 - We have constructed a 1.4-Mb P1 artificial chromosome/bacterial artificial chromosome (PAC/BAC) contig spanning the 17q breakpoint of a constitutional translocation t(1;17)(p36.2;q11.2) in a patient with neuroblastoma. Three 17q breakpoint-overlapping cosmids were identified and sequenced. No coding sequences were found in the immediate proximity of the 17q breakpoint. The PAC/BAC contig covers the region between the proximally located ACCN1 gene and the distally located TLK2 gene and SCYA chemokine gene cluster. The observation that the 17q breakpoint region could not be detected in any of the screened yeast artificial chromosome libraries and the localization of the 17q breakpoint in the vicinity of the distal breakpoints of two microdeletions in patients with neurofibromatosis type 1 suggest that this chromosomal region is genetically unstable and prone to rearrangements

AB - We have constructed a 1.4-Mb P1 artificial chromosome/bacterial artificial chromosome (PAC/BAC) contig spanning the 17q breakpoint of a constitutional translocation t(1;17)(p36.2;q11.2) in a patient with neuroblastoma. Three 17q breakpoint-overlapping cosmids were identified and sequenced. No coding sequences were found in the immediate proximity of the 17q breakpoint. The PAC/BAC contig covers the region between the proximally located ACCN1 gene and the distally located TLK2 gene and SCYA chemokine gene cluster. The observation that the 17q breakpoint region could not be detected in any of the screened yeast artificial chromosome libraries and the localization of the 17q breakpoint in the vicinity of the distal breakpoints of two microdeletions in patients with neurofibromatosis type 1 suggest that this chromosomal region is genetically unstable and prone to rearrangements

U2 - 10.1002/gcc.10034

DO - 10.1002/gcc.10034

M3 - Article

C2 - 12203774

SN - 1045-2257

VL - 35

SP - 113

EP - 120

JO - Genes, chromosomes & cancer

JF - Genes, chromosomes & cancer

IS - 2

ER -

van Roy N, Vandesompele J, Berx G, Staes K, van Gele M, de Smet E et al. Localization of the 17q breakpoint of a constitutional 1;17 translocation in a patient with neuroblastoma within a 25-kb segment located between the ACCN1 and TLK2 genes and near the distal breakpoints of two microdeletions in neurofibromatosis type 1 patients. Genes, chromosomes & cancer. 2002;35(2):113-120. doi: 10.1002/gcc.10034