TY - JOUR
T1 - Lessons Learned
T2 - Quality Analysis of Optical Coherence Tomography in Neuromyelitis Optica
AU - Salih, Hadi
AU - Samadzadeh, Sara
AU - Bereuter, Charlotte
AU - Motamedi, Seyedamirhosein
AU - Chien, Claudia
AU - Villoslada, Pablo
AU - Stiebel-Kalish, Hadas
AU - Asgari, Nasrin
AU - Mao-Draayer, Yang
AU - Ringelstein, Marius
AU - Havla, Joachim
AU - Peixoto, Marco Aurélio Lana
AU - Kim, Ho Jin
AU - Palace, Jacqueline
AU - Leite, Maria Isabel
AU - Sharma, Srilakshmi M.
AU - Ashtari, Fereshteh
AU - Kafieh, Rahele
AU - Pandit, Lekha
AU - Aktas, Orhan
AU - Albrecht, Philipp
AU - Leocani, Letizia
AU - Lotan, Itay
AU - Siritho, Sasitorn
AU - de Seze, J. rôme
AU - Marignier, Romain
AU - Tilikete, Caroline Froment
AU - Bichuetti, Denis Bernardi
AU - Tavares, Ivan Maynart
AU - Altintas, Ayse
AU - Jacob, Anu
AU - Huda, Saif
AU - de Castillo, Ibis Soto
AU - Cook, Lawrence J.
AU - Yeaman, Michael R.
AU - Petzold, Axel
AU - Brandt, Alexander U.
AU - Paul, Friedemann
AU - with the Guthy Jackson Charitable Foundation—International Clinical Consortium and CROCTINO Collaborators
AU - Oertel, Frederike C.
AU - Zimmermann, Hanna G.
N1 - Publisher Copyright:
© 2025 The Author(s). Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.
PY - 2025
Y1 - 2025
N2 - Introduction: Optical coherence tomography (OCT)-derived retina measurements are markers for neuroaxonal visual pathway status. High-quality OCT scans are essential for reliable measurements, but their acquisition is particularly challenging in eyes with severe visual impairment, as often observed in neuromyelitis optica spectrum disorders (NMOSD). Objective: To investigate OCT quality issues in real-world data from the international Collaborative Retrospective Study on Retinal OCT in Neuromyelitis Optica (CROCTINO). Methods: We evaluated the quality of peripapillary and macular OCT scans, using Heidelberg Spectralis SD-OCT, Carl Zeiss Cirrus HD-OCT, or Topcon SD-OCT across 22 centers. Experienced graders applied OSCAR-IB criteria for OCT quality. Eyes were classified as severely visually impaired or not based on a 1.0 logMAR cut-off. Quality outcomes were compared using the Chi-square test. Results: A total of 3075 OCT scans (1630 peripapillary, 1445 macular) from 539 people with NMOSD and related conditions were evaluated. Macular scans were rejected more often than peripapillary scans due to quality issues (20.1% vs. 14.5%, p < 0.001). Rejection rates were higher in eyes with severe visual impairment (peripapillary: 28.9%, macular: 41.6%) compared to eyes without severe visual impairment (peripapillary: 10.7%, p < 0.001; macular: 14.6%, p < 0.001). Conclusion: Our study revealed that approximately one in six scans was rejected due to low quality, with higher rejection rates in eyes with severe visual impairment. As scan quality can bias quantitative outcomes and artificial intelligence applications, these findings emphasize the unmet need for standardized OCT practices tailored to NMOSD and other conditions involving severe visual impairment.
AB - Introduction: Optical coherence tomography (OCT)-derived retina measurements are markers for neuroaxonal visual pathway status. High-quality OCT scans are essential for reliable measurements, but their acquisition is particularly challenging in eyes with severe visual impairment, as often observed in neuromyelitis optica spectrum disorders (NMOSD). Objective: To investigate OCT quality issues in real-world data from the international Collaborative Retrospective Study on Retinal OCT in Neuromyelitis Optica (CROCTINO). Methods: We evaluated the quality of peripapillary and macular OCT scans, using Heidelberg Spectralis SD-OCT, Carl Zeiss Cirrus HD-OCT, or Topcon SD-OCT across 22 centers. Experienced graders applied OSCAR-IB criteria for OCT quality. Eyes were classified as severely visually impaired or not based on a 1.0 logMAR cut-off. Quality outcomes were compared using the Chi-square test. Results: A total of 3075 OCT scans (1630 peripapillary, 1445 macular) from 539 people with NMOSD and related conditions were evaluated. Macular scans were rejected more often than peripapillary scans due to quality issues (20.1% vs. 14.5%, p < 0.001). Rejection rates were higher in eyes with severe visual impairment (peripapillary: 28.9%, macular: 41.6%) compared to eyes without severe visual impairment (peripapillary: 10.7%, p < 0.001; macular: 14.6%, p < 0.001). Conclusion: Our study revealed that approximately one in six scans was rejected due to low quality, with higher rejection rates in eyes with severe visual impairment. As scan quality can bias quantitative outcomes and artificial intelligence applications, these findings emphasize the unmet need for standardized OCT practices tailored to NMOSD and other conditions involving severe visual impairment.
KW - OCT scan quality
KW - OSCAR-IB criteria
KW - neuromyelitis optica spectrum disorders
KW - optic neuritis
KW - optical coherence tomography
UR - https://www.scopus.com/pages/publications/105023962077
U2 - 10.1002/acn3.70235
DO - 10.1002/acn3.70235
M3 - Article
C2 - 41246845
SN - 2328-9503
JO - Annals of clinical and translational neurology
JF - Annals of clinical and translational neurology
ER -