Lending colour to the black box: Insights into the course and burden of primary sclerosing cholangitis

Primary sclerosing cholangitis (PSC) is a rare cholestatic liver disease marked by multifocal bile duct strictures and is strongly associated with inflammatory bowel disease (IBD). The disease runs an unpredictable course with increased risk of developing colorectal and hepatobiliary cancers, frequently culminating in liver transplantation. While its cause remains unclear, no proven medical