Intestinal stem cell dynamics in homeostasis and cancer

Rana Ramadan; Milou S. van Driel; Louis Vermeulen; Sanne M. van Neerven

doi:10.1016/j.trecan.2022.01.011

Intestinal stem cell dynamics in homeostasis and cancer

Rana Ramadan
, Milou S. van Driel
, Louis Vermeulen
, Sanne M. van Neerven^*

^*Corresponding author for this work

Oncode Institute, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands

Research output: Contribution to journal › Review article › Academic › peer-review

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Abstract

The relationship between intestinal stem cells (ISCs) and colorectal cancer (CRC) has been a topic of intense study. Uncovering stem cell dynamics in homeostasis and following acquisition of oncogenic mutations has provided unprecedented insights into CRC initiation, and it is increasingly evident that the microenvironment plays a key role in regulating stem cell fate and functionality. Consequently, imbalances in the signaling between the niche and ISCs perturb homeostasis and promote cancer development. Furthermore, stem cell-like cells drive growth and progression of established CRCs and these cells also critically rely on microenvironmental input. Here, we highlight the importance of stem cell/niche interactions in developing and established CRC and discuss how these can be modulated to develop novel preventive and therapeutic interventions.

Original language	English
Pages (from-to)	416-425
Number of pages	10
Journal	Trends in cancer
Volume	8
Issue number	5
Early online date	2022
DOIs	https://doi.org/10.1016/j.trecan.2022.01.011
Publication status	Published - May 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cell competition
colorectal cancer
intestinal stem cells
microenvironment
mutations
stem cell niche

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Intestinal-stem-cell-dynamics-in-homeostasis-and-cancer.pdfFinal published version, 918 KBLicence: CC BY

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title = "Intestinal stem cell dynamics in homeostasis and cancer",

abstract = "The relationship between intestinal stem cells (ISCs) and colorectal cancer (CRC) has been a topic of intense study. Uncovering stem cell dynamics in homeostasis and following acquisition of oncogenic mutations has provided unprecedented insights into CRC initiation, and it is increasingly evident that the microenvironment plays a key role in regulating stem cell fate and functionality. Consequently, imbalances in the signaling between the niche and ISCs perturb homeostasis and promote cancer development. Furthermore, stem cell-like cells drive growth and progression of established CRCs and these cells also critically rely on microenvironmental input. Here, we highlight the importance of stem cell/niche interactions in developing and established CRC and discuss how these can be modulated to develop novel preventive and therapeutic interventions.",

keywords = "cell competition, colorectal cancer, intestinal stem cells, microenvironment, mutations, stem cell niche",

author = "Rana Ramadan and \{van Driel\}, \{Milou S.\} and Louis Vermeulen and \{van Neerven\}, \{Sanne M.\}",

note = "Funding Information: This work is supported by The New York Stem Cell Foundation and grants from KWF Dutch Cancer Society (UVA2014-7245), the Maurits en Anna de Kock Stichting (2015-2), Worldwide Cancer Research (14-1164), the Maag Lever Darm Stichting (MLDS-CDG 14-03), the European Research Council (ERG-StG 638193), and ZonMw (Vidi 016.156.308) to L.V. L.V. is a New York Stem Cell Foundation?Robertson Investigator. S.M.v.N. is supported by the ?AGEM? Innovation grant (2021), the ?Maurits en Anna de Kock Stichting? (2021-9), and a NWO OOA PhD scholarship (022.005.002). L.V. received consultancy fees from Bayer, MSD, Genentech, Servier, and Pierre Fabre, but these had no relation to the content of this publication. Funding Information: This work is supported by The New York Stem Cell Foundation and grants from KWF Dutch Cancer Society ( UVA2014-7245 ), the Maurits en Anna de Kock Stichting ( 2015-2 ), Worldwide Cancer Research ( 14-1164 ), the Maag Lever Darm Stichting ( MLDS-CDG 14-03 ), the European Research Council ( ERG-StG 638193 ), and ZonMw (Vidi 016.156.308 ) to L.V. L.V. is a New York Stem Cell Foundation –Robertson Investigator. S.M.v.N. is supported by the {\textquoteleft}AGEM{\textquoteright} Innovation grant ( 2021 ), the {\textquoteleft}Maurits en Anna de Kock Stichting{\textquoteright} ( 2021-9 ), and a NWO OOA PhD scholarship ( 022.005.002 ). Publisher Copyright: {\textcopyright} 2022 The Author(s)",

year = "2022",

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doi = "10.1016/j.trecan.2022.01.011",

language = "English",

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AU - Ramadan, Rana

AU - van Driel, Milou S.

AU - Vermeulen, Louis

AU - van Neerven, Sanne M.

N1 - Funding Information: This work is supported by The New York Stem Cell Foundation and grants from KWF Dutch Cancer Society (UVA2014-7245), the Maurits en Anna de Kock Stichting (2015-2), Worldwide Cancer Research (14-1164), the Maag Lever Darm Stichting (MLDS-CDG 14-03), the European Research Council (ERG-StG 638193), and ZonMw (Vidi 016.156.308) to L.V. L.V. is a New York Stem Cell Foundation?Robertson Investigator. S.M.v.N. is supported by the ?AGEM? Innovation grant (2021), the ?Maurits en Anna de Kock Stichting? (2021-9), and a NWO OOA PhD scholarship (022.005.002). L.V. received consultancy fees from Bayer, MSD, Genentech, Servier, and Pierre Fabre, but these had no relation to the content of this publication. Funding Information: This work is supported by The New York Stem Cell Foundation and grants from KWF Dutch Cancer Society ( UVA2014-7245 ), the Maurits en Anna de Kock Stichting ( 2015-2 ), Worldwide Cancer Research ( 14-1164 ), the Maag Lever Darm Stichting ( MLDS-CDG 14-03 ), the European Research Council ( ERG-StG 638193 ), and ZonMw (Vidi 016.156.308 ) to L.V. L.V. is a New York Stem Cell Foundation –Robertson Investigator. S.M.v.N. is supported by the ‘AGEM’ Innovation grant ( 2021 ), the ‘Maurits en Anna de Kock Stichting’ ( 2021-9 ), and a NWO OOA PhD scholarship ( 022.005.002 ). Publisher Copyright: © 2022 The Author(s)

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N2 - The relationship between intestinal stem cells (ISCs) and colorectal cancer (CRC) has been a topic of intense study. Uncovering stem cell dynamics in homeostasis and following acquisition of oncogenic mutations has provided unprecedented insights into CRC initiation, and it is increasingly evident that the microenvironment plays a key role in regulating stem cell fate and functionality. Consequently, imbalances in the signaling between the niche and ISCs perturb homeostasis and promote cancer development. Furthermore, stem cell-like cells drive growth and progression of established CRCs and these cells also critically rely on microenvironmental input. Here, we highlight the importance of stem cell/niche interactions in developing and established CRC and discuss how these can be modulated to develop novel preventive and therapeutic interventions.

AB - The relationship between intestinal stem cells (ISCs) and colorectal cancer (CRC) has been a topic of intense study. Uncovering stem cell dynamics in homeostasis and following acquisition of oncogenic mutations has provided unprecedented insights into CRC initiation, and it is increasingly evident that the microenvironment plays a key role in regulating stem cell fate and functionality. Consequently, imbalances in the signaling between the niche and ISCs perturb homeostasis and promote cancer development. Furthermore, stem cell-like cells drive growth and progression of established CRCs and these cells also critically rely on microenvironmental input. Here, we highlight the importance of stem cell/niche interactions in developing and established CRC and discuss how these can be modulated to develop novel preventive and therapeutic interventions.

KW - cell competition

KW - colorectal cancer

KW - intestinal stem cells

KW - microenvironment

KW - mutations

KW - stem cell niche

UR - https://www.scopus.com/pages/publications/85124416265

U2 - 10.1016/j.trecan.2022.01.011

DO - 10.1016/j.trecan.2022.01.011

M3 - Review article

C2 - 35153158

SN - 2405-8033

VL - 8

SP - 416

EP - 425

JO - Trends in cancer

JF - Trends in cancer

IS - 5

ER -

Intestinal stem cell dynamics in homeostasis and cancer

Abstract

UN SDGs

Keywords

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