TY - JOUR
T1 - INternational Soft Tissue saRcoma ConsorTium (INSTRuCT) consensus statement
T2 - Imaging recommendations for the management of rhabdomyosarcoma
AU - Schoot, Reineke A.
AU - van Ewijk, Roelof
AU - von Witzleben, Anna-Anais
AU - Kao, Simon C.
AU - Merks, J. H. M. (Hans)
AU - Morosi, Carlo
AU - Pace, Erika
AU - Shulkin, Barry L.
AU - Ferrari, Andrea
AU - von Kalle, Thekla
AU - van Rijn, Rick R.
AU - Weiss, Aaron R.
AU - Sparber-Sauer, Monika
AU - ter Horst, Simone A. J.
AU - McCarville, M. (Beth)
N1 - Funding Information:
We wish to thank Suzi Birz, MScMI, FHIMSS, the Regulatory and Data Governance Consultant at the Pediatric Cancer Data Commons, for her excellent administrative assistance in bringing this international consensus manuscript to fruition.
Funding Information:
The International Soft Tissue Sarcoma Consortium and the Pediatric Cancer Data Commons are supported, in part, by Cancer Research Foundation, Children's Research Foundation, Comer Development Board, KickCancer, King Baudouin Foundation, Rally Foundation for Childhood Cancer Research, Seattle Children's Foundation from Kat's Crew Guild through the Sarcoma Research Fund, St. Baldrick's Foundation, and The Andrew McDonough B + Foundation. This work is made possible through the efforts of the Children's Oncology Group (COG), Cooperative Weichteilsarkom Studiengruppe der GPOH (CWS), European paediatric Soft tissue sarcoma Study Group, MMT Malignant Mesenchymal Tumour Committee and STSC AIEOP Italian Soft Tissue Sarcoma Committee, and American Lebanese Syrian Associated Charities (ALSAC).
Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2023/9/1
Y1 - 2023/9/1
N2 - Rhabdomyosarcoma is the most common soft-tissue neoplasm in the pediatric population. The survival of children with rhabdomyosarcoma has only marginally improved over the past 25 years and remains poor for those with metastatic disease. A significant challenge to advances in treatment of rhabdomyosarcoma is the relative rarity of this disease, necessitating years to complete clinical trials. Progress can be accelerated by international cooperation and sharing national experiences. This necessitates agreement on a common language to describe patient cohorts and consensus standards to guide diagnosis, treatment, and response assessment. These goals formed the premise for creating the INternational Soft Tissue saRcoma ConsorTium (INSTRuCT) in 2017. Multidisciplinary members of this consortium have since developed international consensus statements on the diagnosis, treatment, and management of pediatric soft-tissue sarcomas. Herein, members of the INSTRuCT Diagnostic Imaging Working Group present international consensus recommendations for imaging of patients with rhabdomyosarcoma at diagnosis, at staging, and during and after completion of therapy. The intent is to promote a standardized imaging approach to pediatric patients with this malignancy to create more-reliable comparisons of results of clinical trials internationally, thereby accelerating progress in managing rhabdomyosarcoma and improving survival.
AB - Rhabdomyosarcoma is the most common soft-tissue neoplasm in the pediatric population. The survival of children with rhabdomyosarcoma has only marginally improved over the past 25 years and remains poor for those with metastatic disease. A significant challenge to advances in treatment of rhabdomyosarcoma is the relative rarity of this disease, necessitating years to complete clinical trials. Progress can be accelerated by international cooperation and sharing national experiences. This necessitates agreement on a common language to describe patient cohorts and consensus standards to guide diagnosis, treatment, and response assessment. These goals formed the premise for creating the INternational Soft Tissue saRcoma ConsorTium (INSTRuCT) in 2017. Multidisciplinary members of this consortium have since developed international consensus statements on the diagnosis, treatment, and management of pediatric soft-tissue sarcomas. Herein, members of the INSTRuCT Diagnostic Imaging Working Group present international consensus recommendations for imaging of patients with rhabdomyosarcoma at diagnosis, at staging, and during and after completion of therapy. The intent is to promote a standardized imaging approach to pediatric patients with this malignancy to create more-reliable comparisons of results of clinical trials internationally, thereby accelerating progress in managing rhabdomyosarcoma and improving survival.
KW - International sarcoma consortium
KW - Metastatic disease
KW - Pediatric rhabdomyosarcoma
KW - Rhabdomyosarcoma imaging
KW - Soft-tissue neoplasm
UR - https://www.scopus.com/pages/publications/85166524928
U2 - 10.1016/j.ejrad.2023.111012
DO - 10.1016/j.ejrad.2023.111012
M3 - Review article
C2 - 37541182
SN - 0720-048X
VL - 166
SP - 111012
JO - European journal of radiology
JF - European journal of radiology
M1 - 111012
ER -
SDG 3 Good Health and Well-being
SDG 17 Partnerships for the Goals