Interleukin-1A +4845(G> T) polymorphism is a factor predisposing to acne vulgaris

K. Szabó; G. Tax; K. Kis; K. Szegedi; D. G. Teodorescu-Brinzeu; C. Diószegi; A. Koreck; M. Széll; L. Kemény

doi:10.1111/j.1399-0039.2010.01530.x

Interleukin-1A +4845(G> T) polymorphism is a factor predisposing to acne vulgaris

K. Szabó
, G. Tax
, K. Kis
, K. Szegedi
, D. G. Teodorescu-Brinzeu
, C. Diószegi
, A. Koreck
, M. Széll
, L. Kemény

pre-AMC

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Acne vulgaris is a common chronic inflammatory skin disease of multifactorial origin. The aim of this study was to clarify whether known polymorphisms of the interleukin-1A (IL1A) and IL1RN genes play a role in the pathogenesis of acne vulgaris. A positive association was found between the minor T allele of the IL1A +4845(G>T) single nucleotide polymorphism (SNP) and acne, whereas no association was found with respect to any alleles of the variable number of tandem repeats (VNTR) polymorphism of the IL1RN gene. The severity of inflammatory acne symptoms correlated with the percentage of individuals carrying the homozygote T/T genotype. These results may help to elucidate the molecular events leading to the development of acne

Original language	English
Pages (from-to)	411-415
Journal	Tissue antigens
Volume	76
Issue number	5
DOIs	https://doi.org/10.1111/j.1399-0039.2010.01530.x
Publication status	Published - 2010
Externally published	Yes

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10.1111/j.1399-0039.2010.01530.x

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title = "Interleukin-1A +4845(G> T) polymorphism is a factor predisposing to acne vulgaris",

abstract = "Acne vulgaris is a common chronic inflammatory skin disease of multifactorial origin. The aim of this study was to clarify whether known polymorphisms of the interleukin-1A (IL1A) and IL1RN genes play a role in the pathogenesis of acne vulgaris. A positive association was found between the minor T allele of the IL1A +4845(G>T) single nucleotide polymorphism (SNP) and acne, whereas no association was found with respect to any alleles of the variable number of tandem repeats (VNTR) polymorphism of the IL1RN gene. The severity of inflammatory acne symptoms correlated with the percentage of individuals carrying the homozygote T/T genotype. These results may help to elucidate the molecular events leading to the development of acne",

author = "K. Szab{\'o} and G. Tax and K. Kis and K. Szegedi and Teodorescu-Brinzeu, \{D. G.\} and C. Di{\'o}szegi and A. Koreck and M. Sz{\'e}ll and L. Kem{\'e}ny",

year = "2010",

doi = "10.1111/j.1399-0039.2010.01530.x",

language = "English",

volume = "76",

pages = "411--415",

journal = "Tissue antigens",

issn = "0001-2815",

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TY - JOUR

T1 - Interleukin-1A +4845(G> T) polymorphism is a factor predisposing to acne vulgaris

AU - Szabó, K.

AU - Tax, G.

AU - Kis, K.

AU - Szegedi, K.

AU - Teodorescu-Brinzeu, D. G.

AU - Diószegi, C.

AU - Koreck, A.

AU - Széll, M.

AU - Kemény, L.

PY - 2010

Y1 - 2010

N2 - Acne vulgaris is a common chronic inflammatory skin disease of multifactorial origin. The aim of this study was to clarify whether known polymorphisms of the interleukin-1A (IL1A) and IL1RN genes play a role in the pathogenesis of acne vulgaris. A positive association was found between the minor T allele of the IL1A +4845(G>T) single nucleotide polymorphism (SNP) and acne, whereas no association was found with respect to any alleles of the variable number of tandem repeats (VNTR) polymorphism of the IL1RN gene. The severity of inflammatory acne symptoms correlated with the percentage of individuals carrying the homozygote T/T genotype. These results may help to elucidate the molecular events leading to the development of acne

AB - Acne vulgaris is a common chronic inflammatory skin disease of multifactorial origin. The aim of this study was to clarify whether known polymorphisms of the interleukin-1A (IL1A) and IL1RN genes play a role in the pathogenesis of acne vulgaris. A positive association was found between the minor T allele of the IL1A +4845(G>T) single nucleotide polymorphism (SNP) and acne, whereas no association was found with respect to any alleles of the variable number of tandem repeats (VNTR) polymorphism of the IL1RN gene. The severity of inflammatory acne symptoms correlated with the percentage of individuals carrying the homozygote T/T genotype. These results may help to elucidate the molecular events leading to the development of acne

U2 - 10.1111/j.1399-0039.2010.01530.x

DO - 10.1111/j.1399-0039.2010.01530.x

M3 - Article

C2 - 20630038

SN - 0001-2815

VL - 76

SP - 411

EP - 415

JO - Tissue antigens

JF - Tissue antigens

IS - 5

ER -

Interleukin-1A +4845(G> T) polymorphism is a factor predisposing to acne vulgaris

Abstract

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