Interleukin-17 in inflammatory skin disorders

Astrid J. van Beelen; Marcel B. M. Teunissen; Martien L. Kapsenberg; Esther C. de Jong

doi:10.1097/ACI.0b013e3282ef869e

Interleukin-17 in inflammatory skin disorders

Astrid J. van Beelen
, Marcel B. M. Teunissen
, Martien L. Kapsenberg
, Esther C. de Jong

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

PURPOSE OF REVIEW: Recently, a novel and unique subset of interleukin (IL)-17-producing CD4+ T helper (Th17) cells, distinct from Th1 and Th2 cells, was discovered. The question is addressed as to what extent inflammatory skin diseases are associated with the actions of this newly discovered Th17 cell subset. RECENT FINDINGS: Th17 cells are involved in protection against bacterial pathogens. In addition, it is now clear that Th17 cells may also be crucial in the pathogenesis of various chronic inflammatory diseases that were formerly categorized as Th1-mediated disorders. SUMMARY: In this review, we summarize the current knowledge of IL-17 and Th17 cells and discuss the possible role of IL-17 in the pathology of psoriasis, contact hypersensitivity and atopic dermatitis. Whereas IL-17 may play an important role in the pathogenesis of psoriasis and contact hypersensitivity, its role in atopic dermatitis is still unclear

Original language	English
Pages (from-to)	374-381
Journal	Current opinion in allergy and clinical immunology
Volume	7
Issue number	5
DOIs	https://doi.org/10.1097/ACI.0b013e3282ef869e
Publication status	Published - 2007

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title = "Interleukin-17 in inflammatory skin disorders",

abstract = "PURPOSE OF REVIEW: Recently, a novel and unique subset of interleukin (IL)-17-producing CD4+ T helper (Th17) cells, distinct from Th1 and Th2 cells, was discovered. The question is addressed as to what extent inflammatory skin diseases are associated with the actions of this newly discovered Th17 cell subset. RECENT FINDINGS: Th17 cells are involved in protection against bacterial pathogens. In addition, it is now clear that Th17 cells may also be crucial in the pathogenesis of various chronic inflammatory diseases that were formerly categorized as Th1-mediated disorders. SUMMARY: In this review, we summarize the current knowledge of IL-17 and Th17 cells and discuss the possible role of IL-17 in the pathology of psoriasis, contact hypersensitivity and atopic dermatitis. Whereas IL-17 may play an important role in the pathogenesis of psoriasis and contact hypersensitivity, its role in atopic dermatitis is still unclear",

author = "\{van Beelen\}, \{Astrid J.\} and Teunissen, \{Marcel B. M.\} and Kapsenberg, \{Martien L.\} and \{de Jong\}, \{Esther C.\}",

year = "2007",

doi = "10.1097/ACI.0b013e3282ef869e",

language = "English",

volume = "7",

pages = "374--381",

journal = "Current opinion in allergy and clinical immunology",

issn = "1528-4050",

publisher = "Lippincott Williams and Wilkins",

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}

TY - JOUR

T1 - Interleukin-17 in inflammatory skin disorders

AU - van Beelen, Astrid J.

AU - Teunissen, Marcel B. M.

AU - Kapsenberg, Martien L.

AU - de Jong, Esther C.

PY - 2007

Y1 - 2007

N2 - PURPOSE OF REVIEW: Recently, a novel and unique subset of interleukin (IL)-17-producing CD4+ T helper (Th17) cells, distinct from Th1 and Th2 cells, was discovered. The question is addressed as to what extent inflammatory skin diseases are associated with the actions of this newly discovered Th17 cell subset. RECENT FINDINGS: Th17 cells are involved in protection against bacterial pathogens. In addition, it is now clear that Th17 cells may also be crucial in the pathogenesis of various chronic inflammatory diseases that were formerly categorized as Th1-mediated disorders. SUMMARY: In this review, we summarize the current knowledge of IL-17 and Th17 cells and discuss the possible role of IL-17 in the pathology of psoriasis, contact hypersensitivity and atopic dermatitis. Whereas IL-17 may play an important role in the pathogenesis of psoriasis and contact hypersensitivity, its role in atopic dermatitis is still unclear

AB - PURPOSE OF REVIEW: Recently, a novel and unique subset of interleukin (IL)-17-producing CD4+ T helper (Th17) cells, distinct from Th1 and Th2 cells, was discovered. The question is addressed as to what extent inflammatory skin diseases are associated with the actions of this newly discovered Th17 cell subset. RECENT FINDINGS: Th17 cells are involved in protection against bacterial pathogens. In addition, it is now clear that Th17 cells may also be crucial in the pathogenesis of various chronic inflammatory diseases that were formerly categorized as Th1-mediated disorders. SUMMARY: In this review, we summarize the current knowledge of IL-17 and Th17 cells and discuss the possible role of IL-17 in the pathology of psoriasis, contact hypersensitivity and atopic dermatitis. Whereas IL-17 may play an important role in the pathogenesis of psoriasis and contact hypersensitivity, its role in atopic dermatitis is still unclear

U2 - 10.1097/ACI.0b013e3282ef869e

DO - 10.1097/ACI.0b013e3282ef869e

M3 - Review article

C2 - 17873575

SN - 1528-4050

VL - 7

SP - 374

EP - 381

JO - Current opinion in allergy and clinical immunology

JF - Current opinion in allergy and clinical immunology

IS - 5

ER -

Interleukin-17 in inflammatory skin disorders

Abstract

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