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Inhibition of m3 muscarinic acetylcholine receptors by local anaesthetics
M. W. Hollmann
, C. H. Ritter
, P. Henle
, M. de Klaver
, G. L. Kamatchi
, M. E. Durieux
Other Departments
Affiliatie UvA
Research output
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peer-review
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Keyphrases
M3 muscarinic Acetylcholine Receptor
100%
Local Anesthetics
100%
Lidocaine
37%
Muscarinic Receptors
37%
Binding Site
25%
IC50
25%
M3 Receptor
25%
M1 Receptor
25%
Signaling Pathway
12%
Inhibitory Effect
12%
N-terminus
12%
Ca(II)
12%
Antisense
12%
Acetyl
12%
Bromide
12%
Alpha Subunit
12%
Benzocaine
12%
Xenopus Oocytes
12%
Concentration-dependent
12%
M3 muscarinic Receptor
12%
Non-competitive
12%
Receptor Molecules
12%
Local Anesthetic Activity
12%
Two-electrode Voltage Clamp
12%
G Protein α Subunit
12%
Chimeric Antigen Receptor T Cells (CAR-T)
12%
Extracellular Loop
12%
Pharmacology, Toxicology and Pharmaceutical Science
Muscarinic Receptor
100%
Local Anesthetic Agent
100%
Receptor
66%
Lidocaine
33%
Binding Site
22%
Muscarinic M1 Receptor
22%
Methacholine
11%
Benzocaine
11%
Xenopus
11%
Guanine Nucleotide Binding Protein Alpha Subunit
11%
Muscarinic M3 Receptor
11%