Infectie met Mycobacterium genavense bij 2 HIV-seropositieve patiënten in Amsterdam

E. J. Kuijper; M. de Witte; D. W. Verhagen; A. H. Kolk; J. T. van der Meer; J. Dankert

Infectie met Mycobacterium genavense bij 2 HIV-seropositieve patiënten in Amsterdam

E. J. Kuijper, M. de Witte, D. W. Verhagen, A. H. Kolk, J. T. van der Meer, J. Dankert

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Abstract

Two patients with an HIV-I infection, a man aged 47 with confusion, aphasia and diarrhoea, and a man aged 32 with dysphagia, a non-productive cough and diarrhoea, were diagnosed as having a disseminated Mycobacterium genavense infection. Both had low counts of CD4+ T lymphocytes. They responded to antimycobacterial treatment. M. genavense was recognized in Geneva in the early nineties as a causative agent of disseminated mycobacterial infections in HIV-seropositive patients with poor cellular immunity. The clinical picture resembles that of a generalized infection with M. avium-intracellulare. M. genavense is a slowly growing mycobacterium which can be isolated and identified using enriched nutrient media and molecular-biological techniques. The infection probably begins in the gastrointestinal tract after oral contamination. DNA of M. genavense can be demonstrated in 25% of the intestinal biopsy samples of non-HIV-seropositive patients

Original language	Dutch
Pages (from-to)	970-972
Journal	Nederlands tijdschrift voor geneeskunde
Volume	142
Issue number	17
Publication status	Published - 1998

Cite this

@article{217d6e00d7434471a3c3b7aa582c9e6e,

title = "Infectie met Mycobacterium genavense bij 2 HIV-seropositieve pati{\"e}nten in Amsterdam",

abstract = "Two patients with an HIV-I infection, a man aged 47 with confusion, aphasia and diarrhoea, and a man aged 32 with dysphagia, a non-productive cough and diarrhoea, were diagnosed as having a disseminated Mycobacterium genavense infection. Both had low counts of CD4+ T lymphocytes. They responded to antimycobacterial treatment. M. genavense was recognized in Geneva in the early nineties as a causative agent of disseminated mycobacterial infections in HIV-seropositive patients with poor cellular immunity. The clinical picture resembles that of a generalized infection with M. avium-intracellulare. M. genavense is a slowly growing mycobacterium which can be isolated and identified using enriched nutrient media and molecular-biological techniques. The infection probably begins in the gastrointestinal tract after oral contamination. DNA of M. genavense can be demonstrated in 25% of the intestinal biopsy samples of non-HIV-seropositive patients",

author = "Kuijper, {E. J.} and {de Witte}, M. and Verhagen, {D. W.} and Kolk, {A. H.} and {van der Meer}, {J. T.} and J. Dankert",

year = "1998",

language = "Dutch",

volume = "142",

pages = "970--972",

journal = "Nederlands tijdschrift voor geneeskunde",

issn = "0028-2162",

publisher = "Bohn Stafleu Van Loghum",

number = "17",

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TY - JOUR

T1 - Infectie met Mycobacterium genavense bij 2 HIV-seropositieve patiënten in Amsterdam

AU - Kuijper, E. J.

AU - de Witte, M.

AU - Verhagen, D. W.

AU - Kolk, A. H.

AU - van der Meer, J. T.

AU - Dankert, J.

PY - 1998

Y1 - 1998

N2 - Two patients with an HIV-I infection, a man aged 47 with confusion, aphasia and diarrhoea, and a man aged 32 with dysphagia, a non-productive cough and diarrhoea, were diagnosed as having a disseminated Mycobacterium genavense infection. Both had low counts of CD4+ T lymphocytes. They responded to antimycobacterial treatment. M. genavense was recognized in Geneva in the early nineties as a causative agent of disseminated mycobacterial infections in HIV-seropositive patients with poor cellular immunity. The clinical picture resembles that of a generalized infection with M. avium-intracellulare. M. genavense is a slowly growing mycobacterium which can be isolated and identified using enriched nutrient media and molecular-biological techniques. The infection probably begins in the gastrointestinal tract after oral contamination. DNA of M. genavense can be demonstrated in 25% of the intestinal biopsy samples of non-HIV-seropositive patients

AB - Two patients with an HIV-I infection, a man aged 47 with confusion, aphasia and diarrhoea, and a man aged 32 with dysphagia, a non-productive cough and diarrhoea, were diagnosed as having a disseminated Mycobacterium genavense infection. Both had low counts of CD4+ T lymphocytes. They responded to antimycobacterial treatment. M. genavense was recognized in Geneva in the early nineties as a causative agent of disseminated mycobacterial infections in HIV-seropositive patients with poor cellular immunity. The clinical picture resembles that of a generalized infection with M. avium-intracellulare. M. genavense is a slowly growing mycobacterium which can be isolated and identified using enriched nutrient media and molecular-biological techniques. The infection probably begins in the gastrointestinal tract after oral contamination. DNA of M. genavense can be demonstrated in 25% of the intestinal biopsy samples of non-HIV-seropositive patients

M3 - Article

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SN - 0028-2162

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JO - Nederlands tijdschrift voor geneeskunde

JF - Nederlands tijdschrift voor geneeskunde

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