Increases in myeloperoxidase levels after exercise in myocardial perfusion scintigraphy are not induced by myocardial ischemia

P. M. van der Zee; M. C. Meuwese; H. J. Verberne; M. de Ruijter; J. P. van Straalen; J. C. Fischer; A. Sturk; B. L. F. van Eck-Smit; E. S. G. Stroes; R. J. de Winter

doi:10.1016/j.cca.2008.06.011

Increases in myeloperoxidase levels after exercise in myocardial perfusion scintigraphy are not induced by myocardial ischemia

P. M. van der Zee
, M. C. Meuwese
, H. J. Verberne
, M. de Ruijter
, J. P. van Straalen
, J. C. Fischer
, A. Sturk
, B. L. F. van Eck-Smit
, E. S. G. Stroes
, R. J. de Winter

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: Increased systemic levels of myeloperoxidase (MPO) have been reported in patients with acute myocardial ischemia. We studied the association between exercise-induced myocardial ischemia measured by myocardial perfusion scintigraphy (MPS) and the magnitude and time course of changes in MPO levels in humans. Methods: One hundred and twenty six patients underwent symptom limited exercise MPS. Myocardial ischemia was assessed semi-quantitatively. Plasma samples were taken before the start of exercise (baseline), at maximum exercise and every hour up to 6 h after maximum exercise. Results: Myocardial ischemia was present in 42 (33%) patients. MPO levels rapidly increased during exercise in patients with and without ischemia (to 131% (106-172%) and 145% (121-199%) of baseline, respectively). MPO levels and absolute changes in MPO did not differ between patients with and without ischemia at any time point. None of the patient characteristics, including presence of ischemia. was independently predictive of the absolute increase in MPO levels during exercise. Conclusions: Exercise related immediate increases in MPO levels do not reflect myocardial ischemia. (C) 2008 Elsevier B.V. All rights reserved

Original language	English
Pages (from-to)	146-150
Journal	Clinica chimica acta; international journal of clinical chemistry
Volume	395
Issue number	1-2
DOIs	https://doi.org/10.1016/j.cca.2008.06.011
Publication status	Published - 2008

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van der Zee, P. M., Meuwese, M. C., Verberne, H. J., de Ruijter, M., van Straalen, J. P., Fischer, J. C., Sturk, A., van Eck-Smit, B. L. F., Stroes, E. S. G., & de Winter, R. J. (2008). Increases in myeloperoxidase levels after exercise in myocardial perfusion scintigraphy are not induced by myocardial ischemia. Clinica chimica acta; international journal of clinical chemistry, 395(1-2), 146-150. https://doi.org/10.1016/j.cca.2008.06.011

@article{b44cca9beb714a1cb63e67e54ef6368c,

title = "Increases in myeloperoxidase levels after exercise in myocardial perfusion scintigraphy are not induced by myocardial ischemia",

abstract = "Background: Increased systemic levels of myeloperoxidase (MPO) have been reported in patients with acute myocardial ischemia. We studied the association between exercise-induced myocardial ischemia measured by myocardial perfusion scintigraphy (MPS) and the magnitude and time course of changes in MPO levels in humans. Methods: One hundred and twenty six patients underwent symptom limited exercise MPS. Myocardial ischemia was assessed semi-quantitatively. Plasma samples were taken before the start of exercise (baseline), at maximum exercise and every hour up to 6 h after maximum exercise. Results: Myocardial ischemia was present in 42 (33\%) patients. MPO levels rapidly increased during exercise in patients with and without ischemia (to 131\% (106-172\%) and 145\% (121-199\%) of baseline, respectively). MPO levels and absolute changes in MPO did not differ between patients with and without ischemia at any time point. None of the patient characteristics, including presence of ischemia. was independently predictive of the absolute increase in MPO levels during exercise. Conclusions: Exercise related immediate increases in MPO levels do not reflect myocardial ischemia. (C) 2008 Elsevier B.V. All rights reserved",

author = "\{van der Zee\}, \{P. M.\} and Meuwese, \{M. C.\} and Verberne, \{H. J.\} and \{de Ruijter\}, M. and \{van Straalen\}, \{J. P.\} and Fischer, \{J. C.\} and A. Sturk and \{van Eck-Smit\}, \{B. L. F.\} and Stroes, \{E. S. G.\} and \{de Winter\}, \{R. J.\}",

year = "2008",

doi = "10.1016/j.cca.2008.06.011",

language = "English",

volume = "395",

pages = "146--150",

journal = "Clinica chimica acta; international journal of clinical chemistry",

issn = "0009-8981",

publisher = "Elsevier",

number = "1-2",

}

van der Zee, PM, Meuwese, MC, Verberne, HJ, de Ruijter, M, van Straalen, JP, Fischer, JC, Sturk, A, van Eck-Smit, BLF, Stroes, ESG & de Winter, RJ 2008, 'Increases in myeloperoxidase levels after exercise in myocardial perfusion scintigraphy are not induced by myocardial ischemia', Clinica chimica acta; international journal of clinical chemistry, vol. 395, no. 1-2, pp. 146-150. https://doi.org/10.1016/j.cca.2008.06.011

Increases in myeloperoxidase levels after exercise in myocardial perfusion scintigraphy are not induced by myocardial ischemia. / van der Zee, P. M.; Meuwese, M. C.; Verberne, H. J. et al.
In: Clinica chimica acta; international journal of clinical chemistry, Vol. 395, No. 1-2, 2008, p. 146-150.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Increases in myeloperoxidase levels after exercise in myocardial perfusion scintigraphy are not induced by myocardial ischemia

AU - van der Zee, P. M.

AU - Meuwese, M. C.

AU - Verberne, H. J.

AU - de Ruijter, M.

AU - van Straalen, J. P.

AU - Fischer, J. C.

AU - Sturk, A.

AU - van Eck-Smit, B. L. F.

AU - Stroes, E. S. G.

AU - de Winter, R. J.

PY - 2008

Y1 - 2008

N2 - Background: Increased systemic levels of myeloperoxidase (MPO) have been reported in patients with acute myocardial ischemia. We studied the association between exercise-induced myocardial ischemia measured by myocardial perfusion scintigraphy (MPS) and the magnitude and time course of changes in MPO levels in humans. Methods: One hundred and twenty six patients underwent symptom limited exercise MPS. Myocardial ischemia was assessed semi-quantitatively. Plasma samples were taken before the start of exercise (baseline), at maximum exercise and every hour up to 6 h after maximum exercise. Results: Myocardial ischemia was present in 42 (33%) patients. MPO levels rapidly increased during exercise in patients with and without ischemia (to 131% (106-172%) and 145% (121-199%) of baseline, respectively). MPO levels and absolute changes in MPO did not differ between patients with and without ischemia at any time point. None of the patient characteristics, including presence of ischemia. was independently predictive of the absolute increase in MPO levels during exercise. Conclusions: Exercise related immediate increases in MPO levels do not reflect myocardial ischemia. (C) 2008 Elsevier B.V. All rights reserved

AB - Background: Increased systemic levels of myeloperoxidase (MPO) have been reported in patients with acute myocardial ischemia. We studied the association between exercise-induced myocardial ischemia measured by myocardial perfusion scintigraphy (MPS) and the magnitude and time course of changes in MPO levels in humans. Methods: One hundred and twenty six patients underwent symptom limited exercise MPS. Myocardial ischemia was assessed semi-quantitatively. Plasma samples were taken before the start of exercise (baseline), at maximum exercise and every hour up to 6 h after maximum exercise. Results: Myocardial ischemia was present in 42 (33%) patients. MPO levels rapidly increased during exercise in patients with and without ischemia (to 131% (106-172%) and 145% (121-199%) of baseline, respectively). MPO levels and absolute changes in MPO did not differ between patients with and without ischemia at any time point. None of the patient characteristics, including presence of ischemia. was independently predictive of the absolute increase in MPO levels during exercise. Conclusions: Exercise related immediate increases in MPO levels do not reflect myocardial ischemia. (C) 2008 Elsevier B.V. All rights reserved

U2 - 10.1016/j.cca.2008.06.011

DO - 10.1016/j.cca.2008.06.011

M3 - Article

C2 - 18601914

SN - 0009-8981

VL - 395

SP - 146

EP - 150

JO - Clinica chimica acta; international journal of clinical chemistry

JF - Clinica chimica acta; international journal of clinical chemistry

IS - 1-2

ER -

Increases in myeloperoxidase levels after exercise in myocardial perfusion scintigraphy are not induced by myocardial ischemia

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