Incidence, Risk Factors and Outcome of Suspected Central Venous Catheter-related Infections in Critically Ill COVID-19 Patients: A Multicenter Retrospective Cohort Study

Jasper M Smit; Lotte Exterkate; Arne J van Tienhoven; Mark E Haaksma; Micah L A Heldeweg; Lucas Fleuren; Patrick Thoral; Tariq A Dam; Leo M A Heunks; Diederik Gommers; Olaf L Cremer; Rob J Bosman; Sander Rigter; Evert-Jan Wils; Tim Frenzel; Alexander P Vlaar; Dave A Dongelmans; Remko de Jong; Marco Peters; Marlijn J A Kamps; Dharmanand Ramnarain; Ralph Nowitzky; Fleur G C A Nooteboom; Wouter de Ruijter; Louise C Urlings-Strop; Ellen G M Smit; D Jannet Mehagnoul-Schipper; Tom Dormans; Cornelis P C de Jager; Stefaan H A Hendriks; Sefanja Achterberg; Evelien Oostdijk; Auke C Reidinga; Barbara Festen-Spanjer; Gert B Brunnekreef; Alexander D Cornet; Walter van den Tempel; Age D Boelens; Peter Koetsier; Judith Lens; Harald J Faber; A Karakus; Robert Entjes; Paul de Jong; Thijs C D Rettig; Sesmu Arbous; Bas Vonk; Tomas Machado; Armand R J Girbes; Elske Sieswerda; Paul W G Elbers; Pieter R Tuinman

doi:10.1097/SHK.0000000000001994

Incidence, Risk Factors and Outcome of Suspected Central Venous Catheter-related Infections in Critically Ill COVID-19 Patients: A Multicenter Retrospective Cohort Study

Jasper M Smit
, Lotte Exterkate
, Arne J van Tienhoven
, Mark E Haaksma
, Micah L A Heldeweg
, Lucas Fleuren
, Patrick Thoral
, Tariq A Dam
, Leo M A Heunks
, Diederik Gommers
, Olaf L Cremer
, Rob J Bosman
, Sander Rigter
, Evert-Jan Wils
, Tim Frenzel
, Alexander P Vlaar
, Dave A Dongelmans
, Remko de Jong
, Marco Peters
, Marlijn J A Kamps

Dharmanand Ramnarain, Ralph Nowitzky, Fleur G C A Nooteboom, Wouter de Ruijter, Louise C Urlings-Strop, Ellen G M Smit, D Jannet Mehagnoul-Schipper, Tom Dormans, Cornelis P C de Jager, Stefaan H A Hendriks, Sefanja Achterberg, Evelien Oostdijk, Auke C Reidinga, Barbara Festen-Spanjer, Gert B Brunnekreef, Alexander D Cornet, Walter van den Tempel, Age D Boelens, Peter Koetsier, Judith Lens, Harald J Faber, A Karakus, Robert Entjes, Paul de Jong, Thijs C D Rettig, Sesmu Arbous, Bas Vonk, Tomas Machado, Armand R J Girbes, Elske Sieswerda, Paul W G Elbers, Pieter R Tuinman

Amsterdam Institute for Infection and Immunity (AII) and Amsterdam Cardiovascular Sciences (ACS)
OLVG
Erasmus Universiteit: Department of Gastroenterology and Hepatology, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands and the Department of Gastroenterology and Hepatology, Academic Medical Center, University Medical Center, Amsterdam,
MCvdW, LB, RPvdH, MCvdW, RPvdH, Department of Surgery, (MNS, HJB), Department of Anaesthesiology (SNH), Laboratory of Experimental Intensive Care and Anaesthesiology (L·E·I·C·A), Amsterdam University Medical Centres, Location AMC, Amsterdam, The Netherlands (ATB, MJS), Department of Anaesthesiology and Intensive Care, Pulmonary Engineering Group, University Hospital
Radboud University Medical Center, Radboud Institute for Health Sciences
1 Intensive Care, Laboratory of Experimental Intensive Care and Anesthesiology.
Intensive Care Medicine Division, Department of Medicine,
Haaglanden Medisch Centrum
ICU, Maasstad Ziekenhuis Rotterdam, Rotterdam, The Netherlands
ICU, SEH, BWC, Martiniziekenhuis, Groningen, The Netherlands
Wilhelmina Hospital Assen
Department of Anesthesia and Intensive Care, Freetown, United States
Department of Anesthesiology
Pacmed
Erasmus Center for Biomics, Erasmus Medical Center, Rotterdam, The Netherlands.
Department of Intensive Care Medicine, Lucerne Cantonal Hospital, Lucerne, Switzerland; Department of Anaesthesiology and Intensive Care, University of Tartu, Tartu, Estonia. [email protected].
St. Antonius Hospital
From the Department of Intensive Care Medicine, Brain Center Rudolf Magnus (C.S.G., A.J.C.S.), Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus (C.S.G., B.H.V., G.J.E.R.), and Department of Radiology (J.W.D.), University Medical Center Utrecht, Utrecht University, the Netherlands; Department of Critical Care, University Medical Center Groningen...
Radboud University Medical Center, Radboud Institute for Health Sciences, IQ healthcare, Nijmegen; and Radboud University Medical Center, Department of Primary and Community Care, Nijmegen, the Netherlands.
Cardiothoracic Anaesthesiology and Intensive Care, Department of Anaesthesiology and Intensive Care Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
Department of Anesthesiology, Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands. [email protected].
Hospital Diakonessenhuis

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background: Aims of this study were to investigate the prevalence and incidence of catheter-related infection, identify risk factors, and determine the relation of catheter-related infection with mortality in critically ill COVID-19 patients. Methods: This was a retrospective cohort study of central venous catheters (CVCs) in critically ill COVID-19 patients. Eligible CVC insertions required an indwelling time of at least 48 hours and were identified using a full-admission electronic health record database. Risk factors were identified using logistic regression. Differences in survival rates at day 28 of follow-up were assessed using a log-rank test and proportional hazard model. Results: In 538 patients, a total of 914 CVCs were included. Prevalence and incidence of suspected catheter-related infection were 7.9% and 9.4 infections per 1,000 catheter indwelling days, respectively. Prone ventilation for more than 5 days was associated with increased risk of suspected catheter-related infection; odds ratio, 5.05 (95% confidence interval 2.12-11.0). Risk of death was significantly higher in patients with suspected catheter-related infection (hazard ratio, 1.78; 95% confidence interval, 1.25-2.53). Conclusions: This study shows that in critically ill patients with COVID-19, prevalence and incidence of suspected catheter-related infection are high, prone ventilation is a risk factor, and mortality is higher in case of catheter-related infection.

Original language	English
Pages (from-to)	358-365
Number of pages	8
Journal	Shock (Augusta, Ga.)
Volume	58
Issue number	5
Early online date	8 Sept 2022
DOIs	https://doi.org/10.1097/SHK.0000000000001994
Publication status	Published - 1 Nov 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

COVID-19
Central venous catheters
catheter-related infections
intensive care

Access to Document

10.1097/SHK.0000000000001994

Incidence-risk-factors-and-outcome-of-suspected-central-venous-catheter-related-infections-in-critically-ill-covid-19-p.pdfFinal published version, 403 KBLicence: Taverne

Cite this

Smit, J. M., Exterkate, L., van Tienhoven, A. J., Haaksma, M. E., Heldeweg, M. L. A., Fleuren, L., Thoral, P., Dam, T. A., Heunks, L. M. A., Gommers, D., Cremer, O. L., Bosman, R. J., Rigter, S., Wils, E.-J., Frenzel, T., Vlaar, A. P., Dongelmans, D. A., de Jong, R., Peters, M., ... Tuinman, P. R. (2022). Incidence, Risk Factors and Outcome of Suspected Central Venous Catheter-related Infections in Critically Ill COVID-19 Patients: A Multicenter Retrospective Cohort Study. Shock (Augusta, Ga.), 58(5), 358-365. https://doi.org/10.1097/SHK.0000000000001994

@article{aae6f6541b444690b1a248f4148bd1e9,

title = "Incidence, Risk Factors and Outcome of Suspected Central Venous Catheter-related Infections in Critically Ill COVID-19 Patients: A Multicenter Retrospective Cohort Study",

abstract = "Background: Aims of this study were to investigate the prevalence and incidence of catheter-related infection, identify risk factors, and determine the relation of catheter-related infection with mortality in critically ill COVID-19 patients. Methods: This was a retrospective cohort study of central venous catheters (CVCs) in critically ill COVID-19 patients. Eligible CVC insertions required an indwelling time of at least 48 hours and were identified using a full-admission electronic health record database. Risk factors were identified using logistic regression. Differences in survival rates at day 28 of follow-up were assessed using a log-rank test and proportional hazard model. Results: In 538 patients, a total of 914 CVCs were included. Prevalence and incidence of suspected catheter-related infection were 7.9\% and 9.4 infections per 1,000 catheter indwelling days, respectively. Prone ventilation for more than 5 days was associated with increased risk of suspected catheter-related infection; odds ratio, 5.05 (95\% confidence interval 2.12-11.0). Risk of death was significantly higher in patients with suspected catheter-related infection (hazard ratio, 1.78; 95\% confidence interval, 1.25-2.53). Conclusions: This study shows that in critically ill patients with COVID-19, prevalence and incidence of suspected catheter-related infection are high, prone ventilation is a risk factor, and mortality is higher in case of catheter-related infection.",

keywords = "COVID-19, Central venous catheters, catheter-related infections, intensive care",

author = "Smit, \{Jasper M\} and Lotte Exterkate and \{van Tienhoven\}, \{Arne J\} and Haaksma, \{Mark E\} and Heldeweg, \{Micah L A\} and Lucas Fleuren and Patrick Thoral and Dam, \{Tariq A\} and Heunks, \{Leo M A\} and Diederik Gommers and Cremer, \{Olaf L\} and Bosman, \{Rob J\} and Sander Rigter and Evert-Jan Wils and Tim Frenzel and Vlaar, \{Alexander P\} and Dongelmans, \{Dave A\} and \{de Jong\}, Remko and Marco Peters and Kamps, \{Marlijn J A\} and Dharmanand Ramnarain and Ralph Nowitzky and Nooteboom, \{Fleur G C A\} and \{de Ruijter\}, Wouter and Urlings-Strop, \{Louise C\} and Smit, \{Ellen G M\} and Mehagnoul-Schipper, \{D Jannet\} and Tom Dormans and \{de Jager\}, \{Cornelis P C\} and Hendriks, \{Stefaan H A\} and Sefanja Achterberg and Evelien Oostdijk and Reidinga, \{Auke C\} and Barbara Festen-Spanjer and Brunnekreef, \{Gert B\} and Cornet, \{Alexander D\} and \{van den Tempel\}, Walter and Boelens, \{Age D\} and Peter Koetsier and Judith Lens and Faber, \{Harald J\} and A Karakus and Robert Entjes and \{de Jong\}, Paul and Rettig, \{Thijs C D\} and Sesmu Arbous and Bas Vonk and Tomas Machado and Girbes, \{Armand R J\} and Elske Sieswerda and Elbers, \{Paul W G\} and Tuinman, \{Pieter R\}",

year = "2022",

month = nov,

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doi = "10.1097/SHK.0000000000001994",

language = "English",

volume = "58",

pages = "358--365",

journal = "Shock (Augusta, Ga.)",

issn = "1073-2322",

publisher = "Lippincott Williams and Wilkins",

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Smit, JM, Exterkate, L, van Tienhoven, AJ, Haaksma, ME , Heldeweg, MLA, Fleuren, L, Thoral, P , Dam, TA, Heunks, LMA, Gommers, D, Cremer, OL, Bosman, RJ, Rigter, S, Wils, E-J, Frenzel, T, Vlaar, AP , Dongelmans, DA, de Jong, R, Peters, M, Kamps, MJA, Ramnarain, D, Nowitzky, R, Nooteboom, FGCA, de Ruijter, W, Urlings-Strop, LC, Smit, EGM, Mehagnoul-Schipper, DJ, Dormans, T, de Jager, CPC, Hendriks, SHA, Achterberg, S, Oostdijk, E, Reidinga, AC, Festen-Spanjer, B, Brunnekreef, GB, Cornet, AD, van den Tempel, W, Boelens, AD, Koetsier, P, Lens, J, Faber, HJ, Karakus, A, Entjes, R, de Jong, P, Rettig, TCD, Arbous, S, Vonk, B, Machado, T, Girbes, ARJ, Sieswerda, E, Elbers, PWG & Tuinman, PR 2022, 'Incidence, Risk Factors and Outcome of Suspected Central Venous Catheter-related Infections in Critically Ill COVID-19 Patients: A Multicenter Retrospective Cohort Study', Shock (Augusta, Ga.), vol. 58, no. 5, pp. 358-365. https://doi.org/10.1097/SHK.0000000000001994

Incidence, Risk Factors and Outcome of Suspected Central Venous Catheter-related Infections in Critically Ill COVID-19 Patients: A Multicenter Retrospective Cohort Study. / Smit, Jasper M; Exterkate, Lotte; van Tienhoven, Arne J et al.
In: Shock (Augusta, Ga.), Vol. 58, No. 5, 01.11.2022, p. 358-365.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Incidence, Risk Factors and Outcome of Suspected Central Venous Catheter-related Infections in Critically Ill COVID-19 Patients

T2 - A Multicenter Retrospective Cohort Study

AU - Smit, Jasper M

AU - Exterkate, Lotte

AU - van Tienhoven, Arne J

AU - Haaksma, Mark E

AU - Heldeweg, Micah L A

AU - Fleuren, Lucas

AU - Thoral, Patrick

AU - Dam, Tariq A

AU - Heunks, Leo M A

AU - Gommers, Diederik

AU - Cremer, Olaf L

AU - Bosman, Rob J

AU - Rigter, Sander

AU - Wils, Evert-Jan

AU - Frenzel, Tim

AU - Vlaar, Alexander P

AU - Dongelmans, Dave A

AU - de Jong, Remko

AU - Peters, Marco

AU - Kamps, Marlijn J A

AU - Ramnarain, Dharmanand

AU - Nowitzky, Ralph

AU - Nooteboom, Fleur G C A

AU - de Ruijter, Wouter

AU - Urlings-Strop, Louise C

AU - Smit, Ellen G M

AU - Mehagnoul-Schipper, D Jannet

AU - Dormans, Tom

AU - de Jager, Cornelis P C

AU - Hendriks, Stefaan H A

AU - Achterberg, Sefanja

AU - Oostdijk, Evelien

AU - Reidinga, Auke C

AU - Festen-Spanjer, Barbara

AU - Brunnekreef, Gert B

AU - Cornet, Alexander D

AU - van den Tempel, Walter

AU - Boelens, Age D

AU - Koetsier, Peter

AU - Lens, Judith

AU - Faber, Harald J

AU - Karakus, A

AU - Entjes, Robert

AU - de Jong, Paul

AU - Rettig, Thijs C D

AU - Arbous, Sesmu

AU - Vonk, Bas

AU - Machado, Tomas

AU - Girbes, Armand R J

AU - Sieswerda, Elske

AU - Elbers, Paul W G

AU - Tuinman, Pieter R

PY - 2022/11/1

Y1 - 2022/11/1

N2 - Background: Aims of this study were to investigate the prevalence and incidence of catheter-related infection, identify risk factors, and determine the relation of catheter-related infection with mortality in critically ill COVID-19 patients. Methods: This was a retrospective cohort study of central venous catheters (CVCs) in critically ill COVID-19 patients. Eligible CVC insertions required an indwelling time of at least 48 hours and were identified using a full-admission electronic health record database. Risk factors were identified using logistic regression. Differences in survival rates at day 28 of follow-up were assessed using a log-rank test and proportional hazard model. Results: In 538 patients, a total of 914 CVCs were included. Prevalence and incidence of suspected catheter-related infection were 7.9% and 9.4 infections per 1,000 catheter indwelling days, respectively. Prone ventilation for more than 5 days was associated with increased risk of suspected catheter-related infection; odds ratio, 5.05 (95% confidence interval 2.12-11.0). Risk of death was significantly higher in patients with suspected catheter-related infection (hazard ratio, 1.78; 95% confidence interval, 1.25-2.53). Conclusions: This study shows that in critically ill patients with COVID-19, prevalence and incidence of suspected catheter-related infection are high, prone ventilation is a risk factor, and mortality is higher in case of catheter-related infection.

AB - Background: Aims of this study were to investigate the prevalence and incidence of catheter-related infection, identify risk factors, and determine the relation of catheter-related infection with mortality in critically ill COVID-19 patients. Methods: This was a retrospective cohort study of central venous catheters (CVCs) in critically ill COVID-19 patients. Eligible CVC insertions required an indwelling time of at least 48 hours and were identified using a full-admission electronic health record database. Risk factors were identified using logistic regression. Differences in survival rates at day 28 of follow-up were assessed using a log-rank test and proportional hazard model. Results: In 538 patients, a total of 914 CVCs were included. Prevalence and incidence of suspected catheter-related infection were 7.9% and 9.4 infections per 1,000 catheter indwelling days, respectively. Prone ventilation for more than 5 days was associated with increased risk of suspected catheter-related infection; odds ratio, 5.05 (95% confidence interval 2.12-11.0). Risk of death was significantly higher in patients with suspected catheter-related infection (hazard ratio, 1.78; 95% confidence interval, 1.25-2.53). Conclusions: This study shows that in critically ill patients with COVID-19, prevalence and incidence of suspected catheter-related infection are high, prone ventilation is a risk factor, and mortality is higher in case of catheter-related infection.

KW - COVID-19

KW - Central venous catheters

KW - catheter-related infections

KW - intensive care

UR - https://www.scopus.com/pages/publications/85143088327

U2 - 10.1097/SHK.0000000000001994

DO - 10.1097/SHK.0000000000001994

M3 - Article

SN - 1073-2322

VL - 58

SP - 358

EP - 365

JO - Shock (Augusta, Ga.)

JF - Shock (Augusta, Ga.)

IS - 5

ER -

Incidence, Risk Factors and Outcome of Suspected Central Venous Catheter-related Infections in Critically Ill COVID-19 Patients: A Multicenter Retrospective Cohort Study

Abstract

UN SDGs

Keywords

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