Improvement of body composition and bone mineral density after enteral nutrition in pediatric Crohn disease

C. Strisciuglio; E. Scarpato; S. Cenni; M. R. Serra; F. P. Giugliano; C. G. Mainolfi; P. Dolce; M. Martinelli; A. Staiano; E. Miele

doi:10.1016/j.dld.2020.03.004

Improvement of body composition and bone mineral density after enteral nutrition in pediatric Crohn disease

C. Strisciuglio
, E. Scarpato
, S. Cenni
, M. R. Serra
, F. P. Giugliano
, C. G. Mainolfi
, P. Dolce
, M. Martinelli
, A. Staiano
, E. Miele

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background:: The relationship between exclusive enteral nutrition (EEN) and bone status is poorly defined in pediatric Crohn disease (CD). Aims:: The aim of this study was to investigate the impact of EEN on body composition, nutritional status, and bone mineral density (BMD) in an incident CD cohort. Methods:: 18 newly diagnosed CD children starting EEN for 8 weeks were prospectively enrolled and evaluated at baseline and after 8 (T8), 26 (T26) and 52 weeks (T52) from diagnosis. The Fat Free Mass (FFM) and the Resting Energy Expenditure (REE) were measured through Bioelectrical Impedance (BIA) and the BMD was assessed by dual-energy X-ray (DXA). We compared DXA data of IBD patients to the data obtained in 15 healthy controls. Results:: CD children had a significant lower BMD compared to healthy control both at baseline (p<0.0001), and after EEN therapy at T52 (p=0.0004); although at this latest time point CD children had a significant increase of BMD compared to baseline (p=0.0015). The BIA analysis showed a significant increase at T26 and T52 of FFM and REE. T52. FFM measured by BIA and BMD measured by DXA were significantly correlated. Conclusion:: EEN improves nutritional status and bone mineral composition.

Original language	English
Pages (from-to)	630-636
Number of pages	7
Journal	Digestive and liver disease
Volume	52
Issue number	6
Early online date	2020
DOIs	https://doi.org/10.1016/j.dld.2020.03.004
Publication status	Published - Jun 2020

Keywords

Bone mineralization
Crohn's disease
Exclusive enteral nutrition
Pediatrics

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10.1016/j.dld.2020.03.004

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@article{b21af7f865a64ff1a11b74dfecbe483d,

title = "Improvement of body composition and bone mineral density after enteral nutrition in pediatric Crohn disease",

abstract = "Background:: The relationship between exclusive enteral nutrition (EEN) and bone status is poorly defined in pediatric Crohn disease (CD). Aims:: The aim of this study was to investigate the impact of EEN on body composition, nutritional status, and bone mineral density (BMD) in an incident CD cohort. Methods:: 18 newly diagnosed CD children starting EEN for 8 weeks were prospectively enrolled and evaluated at baseline and after 8 (T8), 26 (T26) and 52 weeks (T52) from diagnosis. The Fat Free Mass (FFM) and the Resting Energy Expenditure (REE) were measured through Bioelectrical Impedance (BIA) and the BMD was assessed by dual-energy X-ray (DXA). We compared DXA data of IBD patients to the data obtained in 15 healthy controls. Results:: CD children had a significant lower BMD compared to healthy control both at baseline (p<0.0001), and after EEN therapy at T52 (p=0.0004); although at this latest time point CD children had a significant increase of BMD compared to baseline (p=0.0015). The BIA analysis showed a significant increase at T26 and T52 of FFM and REE. T52. FFM measured by BIA and BMD measured by DXA were significantly correlated. Conclusion:: EEN improves nutritional status and bone mineral composition.",

keywords = "Bone mineralization, Crohn's disease, Exclusive enteral nutrition, Pediatrics",

author = "C. Strisciuglio and E. Scarpato and S. Cenni and Serra, \{M. R.\} and Giugliano, \{F. P.\} and Mainolfi, \{C. G.\} and P. Dolce and M. Martinelli and A. Staiano and E. Miele",

note = "Funding Information: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. Publisher Copyright: {\textcopyright} 2020 Editrice Gastroenterologica Italiana S.r.l. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

month = jun,

doi = "10.1016/j.dld.2020.03.004",

language = "English",

volume = "52",

pages = "630--636",

journal = "Digestive and liver disease",

issn = "1590-8658",

publisher = "Elsevier",

number = "6",

}

TY - JOUR

T1 - Improvement of body composition and bone mineral density after enteral nutrition in pediatric Crohn disease

AU - Strisciuglio, C.

AU - Scarpato, E.

AU - Cenni, S.

AU - Serra, M. R.

AU - Giugliano, F. P.

AU - Mainolfi, C. G.

AU - Dolce, P.

AU - Martinelli, M.

AU - Staiano, A.

AU - Miele, E.

N1 - Funding Information: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. Publisher Copyright: © 2020 Editrice Gastroenterologica Italiana S.r.l. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/6

Y1 - 2020/6

N2 - Background:: The relationship between exclusive enteral nutrition (EEN) and bone status is poorly defined in pediatric Crohn disease (CD). Aims:: The aim of this study was to investigate the impact of EEN on body composition, nutritional status, and bone mineral density (BMD) in an incident CD cohort. Methods:: 18 newly diagnosed CD children starting EEN for 8 weeks were prospectively enrolled and evaluated at baseline and after 8 (T8), 26 (T26) and 52 weeks (T52) from diagnosis. The Fat Free Mass (FFM) and the Resting Energy Expenditure (REE) were measured through Bioelectrical Impedance (BIA) and the BMD was assessed by dual-energy X-ray (DXA). We compared DXA data of IBD patients to the data obtained in 15 healthy controls. Results:: CD children had a significant lower BMD compared to healthy control both at baseline (p<0.0001), and after EEN therapy at T52 (p=0.0004); although at this latest time point CD children had a significant increase of BMD compared to baseline (p=0.0015). The BIA analysis showed a significant increase at T26 and T52 of FFM and REE. T52. FFM measured by BIA and BMD measured by DXA were significantly correlated. Conclusion:: EEN improves nutritional status and bone mineral composition.

AB - Background:: The relationship between exclusive enteral nutrition (EEN) and bone status is poorly defined in pediatric Crohn disease (CD). Aims:: The aim of this study was to investigate the impact of EEN on body composition, nutritional status, and bone mineral density (BMD) in an incident CD cohort. Methods:: 18 newly diagnosed CD children starting EEN for 8 weeks were prospectively enrolled and evaluated at baseline and after 8 (T8), 26 (T26) and 52 weeks (T52) from diagnosis. The Fat Free Mass (FFM) and the Resting Energy Expenditure (REE) were measured through Bioelectrical Impedance (BIA) and the BMD was assessed by dual-energy X-ray (DXA). We compared DXA data of IBD patients to the data obtained in 15 healthy controls. Results:: CD children had a significant lower BMD compared to healthy control both at baseline (p<0.0001), and after EEN therapy at T52 (p=0.0004); although at this latest time point CD children had a significant increase of BMD compared to baseline (p=0.0015). The BIA analysis showed a significant increase at T26 and T52 of FFM and REE. T52. FFM measured by BIA and BMD measured by DXA were significantly correlated. Conclusion:: EEN improves nutritional status and bone mineral composition.

KW - Bone mineralization

KW - Crohn's disease

KW - Exclusive enteral nutrition

KW - Pediatrics

UR - https://www.scopus.com/pages/publications/85082828038

U2 - 10.1016/j.dld.2020.03.004

DO - 10.1016/j.dld.2020.03.004

M3 - Article

C2 - 32273172

SN - 1590-8658

VL - 52

SP - 630

EP - 636

JO - Digestive and liver disease

JF - Digestive and liver disease

IS - 6

ER -

Improvement of body composition and bone mineral density after enteral nutrition in pediatric Crohn disease

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Keywords

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