Imaging myocardial angiogenesis

Joanna J. Wykrzykowska; Timothy D. Henry; John R. Lesser; Robert S. Schwartz

doi:10.1038/nrcardio.2009.157

Imaging myocardial angiogenesis

Joanna J. Wykrzykowska
, Timothy D. Henry
, John R. Lesser
, Robert S. Schwartz

Erasmus University Rotterdam
Allina Health

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Imaging myocardial angiogenesis presents a major technical challenge because the ideal spatial resolution required is substantially higher than that available with standard X-ray angiography and nuclear medicine imaging. Moreover, these clinical imaging methods are currently inadequate (because of insufficient resolution) for clinical trials of angiogenic agents for the treatment of ischemic heart disease. Specialized techniques in MRI, ultrasonography, echocardiography and CT that are under development might provide improved means of imaging myocardial angiogenesis. Molecular imaging technologies are also being developed to improve resolution and to provide a better mechanistic insight into angiogenic therapies for ischemic heart diseases. This Review examines advanced methods for imaging angiogenesis. These technologies might soon permit data to be obtained directly from scientific studies and clinical trials. © 2009 Macmillan Publishers Limited. All rights reserved.

Original language	English
Pages (from-to)	648-658
Journal	Nature reviews. Cardiology
Volume	6
Issue number	10
DOIs	https://doi.org/10.1038/nrcardio.2009.157
Publication status	Published - 2009
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1038/nrcardio.2009.157

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title = "Imaging myocardial angiogenesis",

abstract = "Imaging myocardial angiogenesis presents a major technical challenge because the ideal spatial resolution required is substantially higher than that available with standard X-ray angiography and nuclear medicine imaging. Moreover, these clinical imaging methods are currently inadequate (because of insufficient resolution) for clinical trials of angiogenic agents for the treatment of ischemic heart disease. Specialized techniques in MRI, ultrasonography, echocardiography and CT that are under development might provide improved means of imaging myocardial angiogenesis. Molecular imaging technologies are also being developed to improve resolution and to provide a better mechanistic insight into angiogenic therapies for ischemic heart diseases. This Review examines advanced methods for imaging angiogenesis. These technologies might soon permit data to be obtained directly from scientific studies and clinical trials. {\textcopyright} 2009 Macmillan Publishers Limited. All rights reserved.",

author = "Wykrzykowska, \{Joanna J.\} and Henry, \{Timothy D.\} and Lesser, \{John R.\} and Schwartz, \{Robert S.\}",

year = "2009",

doi = "10.1038/nrcardio.2009.157",

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AU - Wykrzykowska, Joanna J.

AU - Henry, Timothy D.

AU - Lesser, John R.

AU - Schwartz, Robert S.

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AB - Imaging myocardial angiogenesis presents a major technical challenge because the ideal spatial resolution required is substantially higher than that available with standard X-ray angiography and nuclear medicine imaging. Moreover, these clinical imaging methods are currently inadequate (because of insufficient resolution) for clinical trials of angiogenic agents for the treatment of ischemic heart disease. Specialized techniques in MRI, ultrasonography, echocardiography and CT that are under development might provide improved means of imaging myocardial angiogenesis. Molecular imaging technologies are also being developed to improve resolution and to provide a better mechanistic insight into angiogenic therapies for ischemic heart diseases. This Review examines advanced methods for imaging angiogenesis. These technologies might soon permit data to be obtained directly from scientific studies and clinical trials. © 2009 Macmillan Publishers Limited. All rights reserved.

UR - https://www.scopus.com/pages/publications/79958137455

UR - https://www.ncbi.nlm.nih.gov/pubmed/19736553

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DO - 10.1038/nrcardio.2009.157

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VL - 6

SP - 648

EP - 658

JO - Nature reviews. Cardiology

JF - Nature reviews. Cardiology

IS - 10

ER -

Imaging myocardial angiogenesis

Abstract

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