IgG4 and release of histamine from human peripheral blood leukocytes

A. W. van Toorenenbergen; R. C. Aalberse

doi:10.1159/000233000

IgG4 and release of histamine from human peripheral blood leukocytes

A. W. van Toorenenbergen
, R. C. Aalberse^*

^*Corresponding author for this work

University of Amsterdam

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Allergen-specific IgG4 was found in the sera from many normal, nonallergic individuals.Basophil leukocytes from donors with IgG4 antibodies to an allergen, but without IgE antibodies to the same allergen, did not release histamine when challenged with this allergen. In some cases, anti-IgG4 antiserum induced a release of histamine from the leukocytes. However, these cells also released histamine after incubation with normal rabbit serum or normal sheep serum. It is concluded that the IgG4-RAST cannot be used for the detection of IgG short-term sensitizing antibodies. © 1982 S. Karger AG, Basel.

Original language	English
Pages (from-to)	117-122
Journal	International archives of allergy and immunology
Volume	67
Issue number	2
DOIs	https://doi.org/10.1159/000233000
Publication status	Published - 1982
Externally published	Yes

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title = "IgG4 and release of histamine from human peripheral blood leukocytes",

abstract = "Allergen-specific IgG4 was found in the sera from many normal, nonallergic individuals.Basophil leukocytes from donors with IgG4 antibodies to an allergen, but without IgE antibodies to the same allergen, did not release histamine when challenged with this allergen. In some cases, anti-IgG4 antiserum induced a release of histamine from the leukocytes. However, these cells also released histamine after incubation with normal rabbit serum or normal sheep serum. It is concluded that the IgG4-RAST cannot be used for the detection of IgG short-term sensitizing antibodies. {\textcopyright} 1982 S. Karger AG, Basel.",

author = "\{van Toorenenbergen\}, \{A. W.\} and Aalberse, \{R. C.\}",

year = "1982",

doi = "10.1159/000233000",

language = "English",

volume = "67",

pages = "117--122",

journal = "International archives of allergy and immunology",

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publisher = "S. Karger AG",

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TY - JOUR

T1 - IgG4 and release of histamine from human peripheral blood leukocytes

AU - van Toorenenbergen, A. W.

AU - Aalberse, R. C.

PY - 1982

Y1 - 1982

N2 - Allergen-specific IgG4 was found in the sera from many normal, nonallergic individuals.Basophil leukocytes from donors with IgG4 antibodies to an allergen, but without IgE antibodies to the same allergen, did not release histamine when challenged with this allergen. In some cases, anti-IgG4 antiserum induced a release of histamine from the leukocytes. However, these cells also released histamine after incubation with normal rabbit serum or normal sheep serum. It is concluded that the IgG4-RAST cannot be used for the detection of IgG short-term sensitizing antibodies. © 1982 S. Karger AG, Basel.

AB - Allergen-specific IgG4 was found in the sera from many normal, nonallergic individuals.Basophil leukocytes from donors with IgG4 antibodies to an allergen, but without IgE antibodies to the same allergen, did not release histamine when challenged with this allergen. In some cases, anti-IgG4 antiserum induced a release of histamine from the leukocytes. However, these cells also released histamine after incubation with normal rabbit serum or normal sheep serum. It is concluded that the IgG4-RAST cannot be used for the detection of IgG short-term sensitizing antibodies. © 1982 S. Karger AG, Basel.

UR - https://www.scopus.com/pages/publications/0020048899

UR - https://www.ncbi.nlm.nih.gov/pubmed/6173336

U2 - 10.1159/000233000

DO - 10.1159/000233000

M3 - Article

C2 - 6173336

SN - 1018-2438

VL - 67

SP - 117

EP - 122

JO - International archives of allergy and immunology

JF - International archives of allergy and immunology

IS - 2

ER -

IgG4 and release of histamine from human peripheral blood leukocytes

Abstract

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