Hydrogen as a Potential Therapeutic Approach in the Treatment of Cancer: From Bench to Bedside

Cancer is still remained among the leading cause of death worldwide, mainly due to the metastatic spread and chemotherapy resistance. In turn chemotherapy is associated with several side effects. Therefore, there is a need to develop new therapies for the management of this condition, reducing toxicity and drug resistance. Recently, hydrogen molecule has been reported as a novel therapeutic approach for many diseases including cancer. there is growing body of data showing the anti-tumor, antioxidant, and anti-inflammatory activity of hydrogen therapy in cancer. Also, various studies have reported the effectiveness of hydrogen therapy in cancer in preclinical setting, However, it is important to note that these studies are still preliminary, and more research is needed to determine the safety and efficacy of hydrogen therapy for cancer treatment. Additionally, while some studies suggest that hydrogen therapy may have potential benefits for certain types of cancer, it is not a cure or replacement for conventional cancer treatments such as chemotherapy or radiation therapy. while there is some evidence to suggest that hydrogen molecules may have therapeutic potential for cancer treatment, more research is needed before any definitive conclusions can be drawn. In this chapter, we provide an overview on the antiproliferative activity of hydrogen and its potential molecular mechanisms of actions followed by recent reports on its potential side effects.