TY - CHAP
T1 - Human Neutrophil Antigens
AU - Blanken, Britt
AU - Kapur, Rick
AU - Vlaar, Alexander P. J.
PY - 2024/1/1
Y1 - 2024/1/1
N2 - Human neutrophil antigens (HNAs) are a family of glycoproteins mainly expressed on human granulocytes. Immune responses to HNA occur via the formation of alloantibodies and/or autoantibodies. These anti-HNAs can be involved in the pathophysiology of several disorders including transfusion-related acute lung injury, fetal and neonatal alloimmune neutropenia, and autoimmune neutropenia. To date, 14 HNA alleles have been identified and divided over five antigen systems (HNA-1, HNA-2, HNA-3, HNA-4, HNA-5). Over the years, several testing strategies for HNA alleles, and the detection of HNA-antibodies have been developed, such as the granulocyte agglutination test and the granulocyte immunofluorescence test.
AB - Human neutrophil antigens (HNAs) are a family of glycoproteins mainly expressed on human granulocytes. Immune responses to HNA occur via the formation of alloantibodies and/or autoantibodies. These anti-HNAs can be involved in the pathophysiology of several disorders including transfusion-related acute lung injury, fetal and neonatal alloimmune neutropenia, and autoimmune neutropenia. To date, 14 HNA alleles have been identified and divided over five antigen systems (HNA-1, HNA-2, HNA-3, HNA-4, HNA-5). Over the years, several testing strategies for HNA alleles, and the detection of HNA-antibodies have been developed, such as the granulocyte agglutination test and the granulocyte immunofluorescence test.
UR - https://www.scopus.com/pages/publications/85213188402
U2 - 10.1016/B978-0-323-96014-4.00081-1
DO - 10.1016/B978-0-323-96014-4.00081-1
M3 - Chapter
SN - 9780323960151
T3 - Transfusion Medicine and Hemostasis: Clinical and Laboratory Aspects
SP - 149
EP - 152
BT - Transfusion Medicine and Hemostasis: Clinical and Laboratory Aspects
PB - Elsevier
ER -