Human endotoxemia induces down-regulation of monocyte CC chemokine receptor 2

Michael Heesen; Rosemarijn Renckens; Alex F. de Vos; Dagmar Kunz; Tom van der Poll

doi:10.1128/CVI.13.1.156-159.2006

Human endotoxemia induces down-regulation of monocyte CC chemokine receptor 2

Michael Heesen
, Rosemarijn Renckens
, Alex F. de Vos
, Dagmar Kunz
, Tom van der Poll

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Upon injection of Escherichia coli lipopolysaccharide into human volunteers, the monocyte density of CC chemokine receptor 2 (CCR2) decreased. Minimal CCR2 density was observed 4 h after injection. Peak plasma concentrations of the CCR2 ligand monocyte chemotactic protein 1 and of tumor necrosis factor alpha were reached after 4 h and 2 h, respectively

Original language	English
Pages (from-to)	156-159
Journal	Clinical and vaccine immunology
Volume	13
Issue number	1
DOIs	https://doi.org/10.1128/CVI.13.1.156-159.2006
Publication status	Published - 2006

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10.1128/CVI.13.1.156-159.2006

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@article{d034405199f54294bf54babc4882a737,

title = "Human endotoxemia induces down-regulation of monocyte CC chemokine receptor 2",

abstract = "Upon injection of Escherichia coli lipopolysaccharide into human volunteers, the monocyte density of CC chemokine receptor 2 (CCR2) decreased. Minimal CCR2 density was observed 4 h after injection. Peak plasma concentrations of the CCR2 ligand monocyte chemotactic protein 1 and of tumor necrosis factor alpha were reached after 4 h and 2 h, respectively",

author = "Michael Heesen and Rosemarijn Renckens and \{de Vos\}, \{Alex F.\} and Dagmar Kunz and \{van der Poll\}, Tom",

year = "2006",

doi = "10.1128/CVI.13.1.156-159.2006",

language = "English",

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AU - Heesen, Michael

AU - Renckens, Rosemarijn

AU - de Vos, Alex F.

AU - Kunz, Dagmar

AU - van der Poll, Tom

PY - 2006

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N2 - Upon injection of Escherichia coli lipopolysaccharide into human volunteers, the monocyte density of CC chemokine receptor 2 (CCR2) decreased. Minimal CCR2 density was observed 4 h after injection. Peak plasma concentrations of the CCR2 ligand monocyte chemotactic protein 1 and of tumor necrosis factor alpha were reached after 4 h and 2 h, respectively

AB - Upon injection of Escherichia coli lipopolysaccharide into human volunteers, the monocyte density of CC chemokine receptor 2 (CCR2) decreased. Minimal CCR2 density was observed 4 h after injection. Peak plasma concentrations of the CCR2 ligand monocyte chemotactic protein 1 and of tumor necrosis factor alpha were reached after 4 h and 2 h, respectively

U2 - 10.1128/CVI.13.1.156-159.2006

DO - 10.1128/CVI.13.1.156-159.2006

M3 - Article

C2 - 16426015

SN - 1556-6811

VL - 13

SP - 156

EP - 159

JO - Clinical and vaccine immunology

JF - Clinical and vaccine immunology

IS - 1

ER -

Human endotoxemia induces down-regulation of monocyte CC chemokine receptor 2

Abstract

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