How to manage coagulopathies in critically ill patients

Julie Helms; Toshiaki Iba; Jean Marie Connors; Satoshi Gando; Marcel Levi; Ferhat Meziani; Jerrold H. Levy

doi:10.1007/s00134-023-06980-6

How to manage coagulopathies in critically ill patients

Julie Helms^*
, Toshiaki Iba
, Jean Marie Connors
, Satoshi Gando
, Marcel Levi
, Ferhat Meziani
, Jerrold H. Levy

^*Corresponding author for this work

Université de Strasbourg
Inserm
Department of Emergency and Disaster Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan
Harvard University
Sapporo Higashi Tokushukai Hospital
Global Center for Biomedical Science and Engineering, Hokkaido University Faculty of Medicine, Kita15, Nishi7, Kita-Ku, Sapporo, Hokkaido, JP, 060-8638, Japan
University College London Hospitals, London, UK
Duke University

Research output: Contribution to journal › Review article › Academic › peer-review

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Abstract

Coagulopathy is a severe and frequent complication in critically ill patients, for which the pathogenesis and presentation may be variable depending on the underlying disease. Based on the dominant clinical phenotype, the current review differentiates between hemorrhagic coagulopathies, characterized by a hypocoagulable and hyperfibrinolysis state, and thrombotic coagulopathies with a systemic prothrombotic and antifibrinolytic phenotype. We discuss the differences in pathogenesis and treatment of the common coagulopathies.

Original language	English
Pages (from-to)	273-290
Number of pages	18
Journal	Intensive care medicine
Volume	49
Issue number	3
Early online date	2023
DOIs	https://doi.org/10.1007/s00134-023-06980-6
Publication status	Published - Mar 2023

Keywords

Coagulopathy
Critical care
Disseminated intravascular coagulation
Hematological disease
Sepsis
Trauma

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title = "How to manage coagulopathies in critically ill patients",

abstract = "Coagulopathy is a severe and frequent complication in critically ill patients, for which the pathogenesis and presentation may be variable depending on the underlying disease. Based on the dominant clinical phenotype, the current review differentiates between hemorrhagic coagulopathies, characterized by a hypocoagulable and hyperfibrinolysis state, and thrombotic coagulopathies with a systemic prothrombotic and antifibrinolytic phenotype. We discuss the differences in pathogenesis and treatment of the common coagulopathies.",

keywords = "Coagulopathy, Critical care, Disseminated intravascular coagulation, Hematological disease, Sepsis, Trauma",

author = "Julie Helms and Toshiaki Iba and Connors, \{Jean Marie\} and Satoshi Gando and Marcel Levi and Ferhat Meziani and Levy, \{Jerrold H.\}",

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doi = "10.1007/s00134-023-06980-6",

language = "English",

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T1 - How to manage coagulopathies in critically ill patients

AU - Helms, Julie

AU - Iba, Toshiaki

AU - Connors, Jean Marie

AU - Gando, Satoshi

AU - Levi, Marcel

AU - Meziani, Ferhat

AU - Levy, Jerrold H.

PY - 2023/3

Y1 - 2023/3

N2 - Coagulopathy is a severe and frequent complication in critically ill patients, for which the pathogenesis and presentation may be variable depending on the underlying disease. Based on the dominant clinical phenotype, the current review differentiates between hemorrhagic coagulopathies, characterized by a hypocoagulable and hyperfibrinolysis state, and thrombotic coagulopathies with a systemic prothrombotic and antifibrinolytic phenotype. We discuss the differences in pathogenesis and treatment of the common coagulopathies.

AB - Coagulopathy is a severe and frequent complication in critically ill patients, for which the pathogenesis and presentation may be variable depending on the underlying disease. Based on the dominant clinical phenotype, the current review differentiates between hemorrhagic coagulopathies, characterized by a hypocoagulable and hyperfibrinolysis state, and thrombotic coagulopathies with a systemic prothrombotic and antifibrinolytic phenotype. We discuss the differences in pathogenesis and treatment of the common coagulopathies.

KW - Coagulopathy

KW - Critical care

KW - Disseminated intravascular coagulation

KW - Hematological disease

KW - Sepsis

KW - Trauma

UR - https://www.scopus.com/pages/publications/85148349344

U2 - 10.1007/s00134-023-06980-6

DO - 10.1007/s00134-023-06980-6

M3 - Review article

C2 - 36808215

SN - 0342-4642

VL - 49

SP - 273

EP - 290

JO - Intensive care medicine

JF - Intensive care medicine

IS - 3

ER -

How to manage coagulopathies in critically ill patients

Abstract

Keywords

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