Homozygous Familial Hypercholesterolemia Is a Life-Limiting Condition: Medical Life-Trajectories in the Post-2010 Era

Janneke W. C. M. Mulder; M. Doortje Reijman; D. Meeike Kusters; Eric Boersma; Fahad Alnouri; Dirk J. Blom; Alberico L. Catapano; Marina Cuchel; Eldad J. Dann; Tomas Freiberger; Urh Groselj; Mariko Harada-Shiba; G. Kees Hovingh; Iulia Iatan; Daiana Ibarretxe; Meral Kayikcioglu; Ngoc-Thanh Kim; Reinhard Klingel; Frederick J. Raal; Laurens F. Reeskamp; Fouzia Sadiq; Willemijn A. M. Schonck; Tycho R. Tromp; Thanh-Huong Truong; Albert Wiegman; Jeanine E. Roeters van Lennep; Khalid Al-Waili; Marcello Arca; Maurizio Averna; Mahmoud H. Ayesh; Francesco Baratta; Andrea Bartuli; Vladimir Blaha; Liam R. Brunham; Paola S. Buonuomo; Paolo Calabrò; Sebastiano Calandra; Manuela Casula; Angelo B. Cefalù; Arturo Cesaro; Sergio D'Addato; Maria del Ben; Laura D'Erasmo; Marat V. Ezhov; Gordon A. Francis; Federica Galimberti; Antonio Gallo; Daniel Gaudet; Jacques Genest; Antonina Giammanco; Mika Hori; Lisa C. Hudgins; Shamanna S. Iyengar; Jessica Lago; Isabelle Ruel; Samir Saheb; Raul D. Santos; Nitika Setia; Handrean Soran; Patrizia Tarugi; Daniele Tramontano; Luya Wang

doi:10.1016/j.jacc.2025.04.005

Homozygous Familial Hypercholesterolemia Is a Life-Limiting Condition: Medical Life-Trajectories in the Post-2010 Era

Janneke W. C. M. Mulder
, M. Doortje Reijman
, D. Meeike Kusters
, Eric Boersma
, Fahad Alnouri
, Dirk J. Blom
, Alberico L. Catapano
, Marina Cuchel
, Eldad J. Dann
, Tomas Freiberger
, Urh Groselj
, Mariko Harada-Shiba
, G. Kees Hovingh
, Iulia Iatan
, Daiana Ibarretxe
, Meral Kayikcioglu
, Ngoc-Thanh Kim
, Reinhard Klingel
, Frederick J. Raal
, Laurens F. Reeskamp

Fouzia Sadiq, Willemijn A. M. Schonck, Tycho R. Tromp, Thanh-Huong Truong, Albert Wiegman^*, Jeanine E. Roeters van Lennep, Khalid Al-Waili, Marcello Arca, Maurizio Averna, Mahmoud H. Ayesh, Francesco Baratta, Andrea Bartuli, Vladimir Blaha, Liam R. Brunham, Paola S. Buonuomo, Paolo Calabrò, Sebastiano Calandra, Manuela Casula, Angelo B. Cefalù, Arturo Cesaro, Sergio D'Addato, Maria del Ben, Laura D'Erasmo, Marat V. Ezhov, Gordon A. Francis, Federica Galimberti, Antonio Gallo, Daniel Gaudet, Jacques Genest, Antonina Giammanco, Mika Hori, Lisa C. Hudgins, Shamanna S. Iyengar, Jessica Lago, Isabelle Ruel, Samir Saheb, Raul D. Santos, Nitika Setia, Handrean Soran, Patrizia Tarugi, Daniele Tramontano, Luya Wang

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Original language	English
Pages (from-to)	1898-1903
Number of pages	6
Journal	Journal of the American College of Cardiology
Volume	85
Issue number	19
DOIs	https://doi.org/10.1016/j.jacc.2025.04.005
Publication status	Published - 20 May 2025

Keywords

ASCVD
LDL-cholesterol
cardiovascular disease
homozygous familial hypercholesterolemia
mortality

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jacc.2025.04.005

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Mulder, J. W. C. M., Reijman, M. D., Kusters, D. M., Boersma, E., Alnouri, F., Blom, D. J., Catapano, A. L., Cuchel, M., Dann, E. J., Freiberger, T., Groselj, U., Harada-Shiba, M., Hovingh, G. K., Iatan, I., Ibarretxe, D., Kayikcioglu, M., Kim, N.-T., Klingel, R., Raal, F. J., ... Wang, L. (2025). Homozygous Familial Hypercholesterolemia Is a Life-Limiting Condition: Medical Life-Trajectories in the Post-2010 Era. Journal of the American College of Cardiology, 85(19), 1898-1903. https://doi.org/10.1016/j.jacc.2025.04.005

@article{03cb273e1de14ed28481526981ed272b,

title = "Homozygous Familial Hypercholesterolemia Is a Life-Limiting Condition: Medical Life-Trajectories in the Post-2010 Era",

keywords = "ASCVD, LDL-cholesterol, cardiovascular disease, homozygous familial hypercholesterolemia, mortality",

author = "Mulder, \{Janneke W. C. M.\} and Reijman, \{M. Doortje\} and Kusters, \{D. Meeike\} and Eric Boersma and Fahad Alnouri and Blom, \{Dirk J.\} and Catapano, \{Alberico L.\} and Marina Cuchel and Dann, \{Eldad J.\} and Tomas Freiberger and Urh Groselj and Mariko Harada-Shiba and Hovingh, \{G. Kees\} and Iulia Iatan and Daiana Ibarretxe and Meral Kayikcioglu and Ngoc-Thanh Kim and Reinhard Klingel and Raal, \{Frederick J.\} and Reeskamp, \{Laurens F.\} and Fouzia Sadiq and Schonck, \{Willemijn A. M.\} and Tromp, \{Tycho R.\} and Thanh-Huong Truong and Albert Wiegman and \{Roeters van Lennep\}, \{Jeanine E.\} and Khalid Al-Waili and Marcello Arca and Maurizio Averna and Ayesh, \{Mahmoud H.\} and Francesco Baratta and Andrea Bartuli and Vladimir Blaha and Brunham, \{Liam R.\} and Buonuomo, \{Paola S.\} and Paolo Calabr{\`o} and Sebastiano Calandra and Manuela Casula and Cefal{\`u}, \{Angelo B.\} and Arturo Cesaro and Sergio D'Addato and \{del Ben\}, Maria and Laura D'Erasmo and Ezhov, \{Marat V.\} and Francis, \{Gordon A.\} and Federica Galimberti and Antonio Gallo and Daniel Gaudet and Jacques Genest and Antonina Giammanco and Mika Hori and Hudgins, \{Lisa C.\} and Iyengar, \{Shamanna S.\} and Jessica Lago and Isabelle Ruel and Samir Saheb and Santos, \{Raul D.\} and Nitika Setia and Handrean Soran and Patrizia Tarugi and Daniele Tramontano and Luya Wang",

year = "2025",

month = may,

day = "20",

doi = "10.1016/j.jacc.2025.04.005",

language = "English",

volume = "85",

pages = "1898--1903",

journal = "Journal of the American College of Cardiology",

issn = "0735-1097",

publisher = "Elsevier USA",

number = "19",

}

Mulder, JWCM, Reijman, MD , Kusters, DM, Boersma, E, Alnouri, F, Blom, DJ, Catapano, AL, Cuchel, M, Dann, EJ, Freiberger, T, Groselj, U, Harada-Shiba, M, Hovingh, GK, Iatan, I, Ibarretxe, D, Kayikcioglu, M, Kim, N-T, Klingel, R, Raal, FJ, Reeskamp, LF, Sadiq, F, Schonck, WAM, Tromp, TR, Truong, T-H, Wiegman, A, Roeters van Lennep, JE, Al-Waili, K, Arca, M, Averna, M, Ayesh, MH, Baratta, F, Bartuli, A, Blaha, V, Brunham, LR, Buonuomo, PS, Calabrò, P, Calandra, S, Casula, M, Cefalù, AB, Cesaro, A, D'Addato, S, del Ben, M, D'Erasmo, L, Ezhov, MV, Francis, GA, Galimberti, F, Gallo, A, Gaudet, D, Genest, J, Giammanco, A, Hori, M, Hudgins, LC, Iyengar, SS, Lago, J, Ruel, I, Saheb, S, Santos, RD, Setia, N, Soran, H, Tarugi, P, Tramontano, D & Wang, L 2025, 'Homozygous Familial Hypercholesterolemia Is a Life-Limiting Condition: Medical Life-Trajectories in the Post-2010 Era', Journal of the American College of Cardiology, vol. 85, no. 19, pp. 1898-1903. https://doi.org/10.1016/j.jacc.2025.04.005

TY - JOUR

T1 - Homozygous Familial Hypercholesterolemia Is a Life-Limiting Condition

T2 - Medical Life-Trajectories in the Post-2010 Era

AU - Mulder, Janneke W. C. M.

AU - Reijman, M. Doortje

AU - Kusters, D. Meeike

AU - Boersma, Eric

AU - Alnouri, Fahad

AU - Blom, Dirk J.

AU - Catapano, Alberico L.

AU - Cuchel, Marina

AU - Dann, Eldad J.

AU - Freiberger, Tomas

AU - Groselj, Urh

AU - Harada-Shiba, Mariko

AU - Hovingh, G. Kees

AU - Iatan, Iulia

AU - Ibarretxe, Daiana

AU - Kayikcioglu, Meral

AU - Kim, Ngoc-Thanh

AU - Klingel, Reinhard

AU - Raal, Frederick J.

AU - Reeskamp, Laurens F.

AU - Sadiq, Fouzia

AU - Schonck, Willemijn A. M.

AU - Tromp, Tycho R.

AU - Truong, Thanh-Huong

AU - Wiegman, Albert

AU - Roeters van Lennep, Jeanine E.

AU - Al-Waili, Khalid

AU - Arca, Marcello

AU - Averna, Maurizio

AU - Ayesh, Mahmoud H.

AU - Baratta, Francesco

AU - Bartuli, Andrea

AU - Blaha, Vladimir

AU - Brunham, Liam R.

AU - Buonuomo, Paola S.

AU - Calabrò, Paolo

AU - Calandra, Sebastiano

AU - Casula, Manuela

AU - Cefalù, Angelo B.

AU - Cesaro, Arturo

AU - D'Addato, Sergio

AU - del Ben, Maria

AU - D'Erasmo, Laura

AU - Ezhov, Marat V.

AU - Francis, Gordon A.

AU - Galimberti, Federica

AU - Gallo, Antonio

AU - Gaudet, Daniel

AU - Genest, Jacques

AU - Giammanco, Antonina

AU - Hori, Mika

AU - Hudgins, Lisa C.

AU - Iyengar, Shamanna S.

AU - Lago, Jessica

AU - Ruel, Isabelle

AU - Saheb, Samir

AU - Santos, Raul D.

AU - Setia, Nitika

AU - Soran, Handrean

AU - Tarugi, Patrizia

AU - Tramontano, Daniele

AU - Wang, Luya

PY - 2025/5/20

Y1 - 2025/5/20

KW - ASCVD

KW - LDL-cholesterol

KW - cardiovascular disease

KW - homozygous familial hypercholesterolemia

KW - mortality

UR - https://www.scopus.com/pages/publications/105004209571

U2 - 10.1016/j.jacc.2025.04.005

DO - 10.1016/j.jacc.2025.04.005

M3 - Article

C2 - 40368578

SN - 0735-1097

VL - 85

SP - 1898

EP - 1903

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

IS - 19

ER -

Homozygous Familial Hypercholesterolemia Is a Life-Limiting Condition: Medical Life-Trajectories in the Post-2010 Era

Keywords

UN SDGs

Access to Document

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