High levels of reticulated platelets and thrombopoietin characterize fetal thrombopoiesis

P. Jilma-Stohlawetz; M. Homoncik; B. Jilma; C. C. Folman; A. E. G. K. von dem Borne; G. Bernaschek; J. Deutinger; B. Ulm; W. Eppel; S. Panzer

doi:10.1046/j.1365-2141.2001.02524.x

High levels of reticulated platelets and thrombopoietin characterize fetal thrombopoiesis

P. Jilma-Stohlawetz
, M. Homoncik
, B. Jilma
, C. C. Folman
, A. E. G. K. von dem Borne
, G. Bernaschek
, J. Deutinger
, B. Ulm
, W. Eppel
, S. Panzer^*

^*Corresponding author for this work

University of Vienna
Amsterdam UMC - University of Amsterdam
University of Amsterdam
Medical University of Vienna

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

To characterize fetal thrombopoiesis, we determined plasma thrombopoietin (TPO) and glycocalicin levels, platelet counts and reticulated platelets (RP) of fetuses and compared them with the respective values of their mothers. Percutaneous umbilical vein sampling in abnormal pregnancies revealed twofold higher thrombopoietin levels and 20-fold higher reticulated platelet counts, but lower levels of glycocalicin in fetuses compared with their mothers (P < 0.05). Neither the expression of platelet glycoprotein Ib and IIb on platelets nor the platelet counts were different between mothers and their fetuses. These data indicate enhanced thrombopoiesis and/or increased platelet turnover in fetuses.

Original language	English
Pages (from-to)	466-468
Journal	British journal of haematology
Volume	112
Issue number	2
DOIs	https://doi.org/10.1046/j.1365-2141.2001.02524.x
Publication status	Published - 2001
Externally published	Yes

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title = "High levels of reticulated platelets and thrombopoietin characterize fetal thrombopoiesis",

abstract = "To characterize fetal thrombopoiesis, we determined plasma thrombopoietin (TPO) and glycocalicin levels, platelet counts and reticulated platelets (RP) of fetuses and compared them with the respective values of their mothers. Percutaneous umbilical vein sampling in abnormal pregnancies revealed twofold higher thrombopoietin levels and 20-fold higher reticulated platelet counts, but lower levels of glycocalicin in fetuses compared with their mothers (P < 0.05). Neither the expression of platelet glycoprotein Ib and IIb on platelets nor the platelet counts were different between mothers and their fetuses. These data indicate enhanced thrombopoiesis and/or increased platelet turnover in fetuses.",

author = "P. Jilma-Stohlawetz and M. Homoncik and B. Jilma and Folman, \{C. C.\} and \{von dem Borne\}, \{A. E. G. K.\} and G. Bernaschek and J. Deutinger and B. Ulm and W. Eppel and S. Panzer",

year = "2001",

doi = "10.1046/j.1365-2141.2001.02524.x",

language = "English",

volume = "112",

pages = "466--468",

journal = "British journal of haematology",

issn = "0007-1048",

publisher = "Wiley Blackwell",

number = "2",

}

TY - JOUR

T1 - High levels of reticulated platelets and thrombopoietin characterize fetal thrombopoiesis

AU - Jilma-Stohlawetz, P.

AU - Homoncik, M.

AU - Jilma, B.

AU - Folman, C. C.

AU - von dem Borne, A. E. G. K.

AU - Bernaschek, G.

AU - Deutinger, J.

AU - Ulm, B.

AU - Eppel, W.

AU - Panzer, S.

PY - 2001

Y1 - 2001

N2 - To characterize fetal thrombopoiesis, we determined plasma thrombopoietin (TPO) and glycocalicin levels, platelet counts and reticulated platelets (RP) of fetuses and compared them with the respective values of their mothers. Percutaneous umbilical vein sampling in abnormal pregnancies revealed twofold higher thrombopoietin levels and 20-fold higher reticulated platelet counts, but lower levels of glycocalicin in fetuses compared with their mothers (P < 0.05). Neither the expression of platelet glycoprotein Ib and IIb on platelets nor the platelet counts were different between mothers and their fetuses. These data indicate enhanced thrombopoiesis and/or increased platelet turnover in fetuses.

AB - To characterize fetal thrombopoiesis, we determined plasma thrombopoietin (TPO) and glycocalicin levels, platelet counts and reticulated platelets (RP) of fetuses and compared them with the respective values of their mothers. Percutaneous umbilical vein sampling in abnormal pregnancies revealed twofold higher thrombopoietin levels and 20-fold higher reticulated platelet counts, but lower levels of glycocalicin in fetuses compared with their mothers (P < 0.05). Neither the expression of platelet glycoprotein Ib and IIb on platelets nor the platelet counts were different between mothers and their fetuses. These data indicate enhanced thrombopoiesis and/or increased platelet turnover in fetuses.

UR - https://www.scopus.com/pages/publications/0035120759

UR - https://www.ncbi.nlm.nih.gov/pubmed/11167848

U2 - 10.1046/j.1365-2141.2001.02524.x

DO - 10.1046/j.1365-2141.2001.02524.x

M3 - Article

C2 - 11167848

SN - 0007-1048

VL - 112

SP - 466

EP - 468

JO - British journal of haematology

JF - British journal of haematology

IS - 2

ER -

High levels of reticulated platelets and thrombopoietin characterize fetal thrombopoiesis

Abstract

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