Heterogeneous expression of melanoma-associated antigens in uveal melanomas

J. P. van der Pol; M. J. Jager; D. de Wolff-Rouendaal; P. J. Ringens; C. Vennegoor; D. J. Ruiter

doi:10.3109/02713688709034842

Heterogeneous expression of melanoma-associated antigens in uveal melanomas

J. P. van der Pol
, M. J. Jager^*
, D. de Wolff-Rouendaal
, P. J. Ringens
, C. Vennegoor
, D. J. Ruiter

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Twenty-five uveal melanomas were stained with seven monoclonal antibodies (MoAbs) recognizing different antigens on cutaneous melanomas. A two step immuno-peroxidase procedure was used. Phenotypic heterogeneity was observed for four MoAbs (M.2.2.4, AMF-7, 225.28S, PAL-M1) while two MoAbs (NKI-beteb, CL203.4) reacted strongly with most (85% uveal melanomas, and one MoAb (R-24) showed very low reactivity. Despite heterogeneity, co-expression of some antigens was observed. Expression of the antigen recognized by MoAb M.2.2.4. was significantly lowered by pre-enucleation irradiation while the other antigens remained unchanged. Expression of antigens on uveal melanomas differed markedly from primary cutaneous melanomas. The clinical relevance of these findings awaits further study. © 1987 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

Original language	English
Pages (from-to)	757-765
Journal	Current eye research
Volume	6
Issue number	6
DOIs	https://doi.org/10.3109/02713688709034842
Publication status	Published - 1987
Externally published	Yes

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10.3109/02713688709034842

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@article{86c4da90a888448eb800929c03296f15,

title = "Heterogeneous expression of melanoma-associated antigens in uveal melanomas",

abstract = "Twenty-five uveal melanomas were stained with seven monoclonal antibodies (MoAbs) recognizing different antigens on cutaneous melanomas. A two step immuno-peroxidase procedure was used. Phenotypic heterogeneity was observed for four MoAbs (M.2.2.4, AMF-7, 225.28S, PAL-M1) while two MoAbs (NKI-beteb, CL203.4) reacted strongly with most (85\% uveal melanomas, and one MoAb (R-24) showed very low reactivity. Despite heterogeneity, co-expression of some antigens was observed. Expression of the antigen recognized by MoAb M.2.2.4. was significantly lowered by pre-enucleation irradiation while the other antigens remained unchanged. Expression of antigens on uveal melanomas differed markedly from primary cutaneous melanomas. The clinical relevance of these findings awaits further study. {\textcopyright} 1987 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.",

author = "\{van der Pol\}, \{J. P.\} and Jager, \{M. J.\} and \{de Wolff-Rouendaal\}, D. and Ringens, \{P. J.\} and C. Vennegoor and Ruiter, \{D. J.\}",

year = "1987",

doi = "10.3109/02713688709034842",

language = "English",

volume = "6",

pages = "757--765",

journal = "Current eye research",

issn = "0271-3683",

publisher = "Taylor and Francis Ltd.",

number = "6",

}

TY - JOUR

T1 - Heterogeneous expression of melanoma-associated antigens in uveal melanomas

AU - van der Pol, J. P.

AU - Jager, M. J.

AU - de Wolff-Rouendaal, D.

AU - Ringens, P. J.

AU - Vennegoor, C.

AU - Ruiter, D. J.

PY - 1987

Y1 - 1987

N2 - Twenty-five uveal melanomas were stained with seven monoclonal antibodies (MoAbs) recognizing different antigens on cutaneous melanomas. A two step immuno-peroxidase procedure was used. Phenotypic heterogeneity was observed for four MoAbs (M.2.2.4, AMF-7, 225.28S, PAL-M1) while two MoAbs (NKI-beteb, CL203.4) reacted strongly with most (85% uveal melanomas, and one MoAb (R-24) showed very low reactivity. Despite heterogeneity, co-expression of some antigens was observed. Expression of the antigen recognized by MoAb M.2.2.4. was significantly lowered by pre-enucleation irradiation while the other antigens remained unchanged. Expression of antigens on uveal melanomas differed markedly from primary cutaneous melanomas. The clinical relevance of these findings awaits further study. © 1987 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

AB - Twenty-five uveal melanomas were stained with seven monoclonal antibodies (MoAbs) recognizing different antigens on cutaneous melanomas. A two step immuno-peroxidase procedure was used. Phenotypic heterogeneity was observed for four MoAbs (M.2.2.4, AMF-7, 225.28S, PAL-M1) while two MoAbs (NKI-beteb, CL203.4) reacted strongly with most (85% uveal melanomas, and one MoAb (R-24) showed very low reactivity. Despite heterogeneity, co-expression of some antigens was observed. Expression of the antigen recognized by MoAb M.2.2.4. was significantly lowered by pre-enucleation irradiation while the other antigens remained unchanged. Expression of antigens on uveal melanomas differed markedly from primary cutaneous melanomas. The clinical relevance of these findings awaits further study. © 1987 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

UR - https://www.scopus.com/pages/publications/0023216470

UR - https://www.ncbi.nlm.nih.gov/pubmed/3608565

U2 - 10.3109/02713688709034842

DO - 10.3109/02713688709034842

M3 - Article

C2 - 3608565

SN - 0271-3683

VL - 6

SP - 757

EP - 765

JO - Current eye research

JF - Current eye research

IS - 6

ER -

Heterogeneous expression of melanoma-associated antigens in uveal melanomas

Abstract

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