Herpes simplex virus type 1 and normal protein permeability in the lungs of critically ill patients: a case for low pathogenicity?

Joanne Verheij; A. B.Johan Groeneveld; Albertus Beishuizen; Arthur van Lingen; Alberdina M. Simoons-Smit; Rob J.M.Strack van Schijndel

doi:10.1186/cc2850

Herpes simplex virus type 1 and normal protein permeability in the lungs of critically ill patients: a case for low pathogenicity?

Joanne Verheij^*
, A. B.Johan Groeneveld
, Albertus Beishuizen
, Arthur van Lingen
, Alberdina M. Simoons-Smit
, Rob J.M.Strack van Schijndel

^*Corresponding author for this work

Vrije Universiteit Amsterdam

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

INTRODUCTION: The pathogenicity of late respiratory infections with herpes simplex virus type 1 (HSV-1) in the critically ill is unclear.

METHODS: In four critically ill patients with persistent pulmonary infiltrates of unknown origin and isolation of HSV-1 from tracheal aspirate or bronchoalveolar lavage fluid, at 7 (1-11) days after start of mechanical ventilatory support, a pulmonary leak index (PLI) for 67Gallium (67Ga)-transferrin (upper limit of normal 14.1 x 10(-3)/min) was measured.

RESULTS: The PLI ranged between 7.5 and 14.0 x 10(-3)/min in the study patients. Two patients received a course of acyclovir and all survived.

CONCLUSIONS: The normal capillary permeability observed in the lungs argues against pathogenicity of HSV-1 in the critically ill, and favors that isolation of the virus reflects reactivation in the course of serious illness and immunodepresssion, rather than primary or superimposed infection in the lungs.

Original language	English
Pages (from-to)	R139
Journal	Critical care (London, England)
Volume	8
Issue number	3
DOIs	https://doi.org/10.1186/cc2850
Publication status	Published - Jun 2004

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adult
Aged
Antiviral Agents/therapeutic use
Bronchoalveolar Lavage Fluid/virology
Capillary Permeability
Critical Illness
Female
Gallium Radioisotopes/pharmacokinetics
Herpesvirus 1, Human/isolation & purification
Humans
Male
Middle Aged
Organometallic Compounds/pharmacokinetics
Pneumonia, Viral/blood
Respiration, Artificial
Respiratory Distress Syndrome/blood
Transferrin/pharmacokinetics
Virulence
Virus Activation

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10.1186/cc2850

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title = "Herpes simplex virus type 1 and normal protein permeability in the lungs of critically ill patients: a case for low pathogenicity?",

abstract = "INTRODUCTION: The pathogenicity of late respiratory infections with herpes simplex virus type 1 (HSV-1) in the critically ill is unclear.METHODS: In four critically ill patients with persistent pulmonary infiltrates of unknown origin and isolation of HSV-1 from tracheal aspirate or bronchoalveolar lavage fluid, at 7 (1-11) days after start of mechanical ventilatory support, a pulmonary leak index (PLI) for 67Gallium (67Ga)-transferrin (upper limit of normal 14.1 x 10(-3)/min) was measured.RESULTS: The PLI ranged between 7.5 and 14.0 x 10(-3)/min in the study patients. Two patients received a course of acyclovir and all survived.CONCLUSIONS: The normal capillary permeability observed in the lungs argues against pathogenicity of HSV-1 in the critically ill, and favors that isolation of the virus reflects reactivation in the course of serious illness and immunodepresssion, rather than primary or superimposed infection in the lungs.",

keywords = "Adult, Aged, Antiviral Agents/therapeutic use, Bronchoalveolar Lavage Fluid/virology, Capillary Permeability, Critical Illness, Female, Gallium Radioisotopes/pharmacokinetics, Herpesvirus 1, Human/isolation \& purification, Humans, Male, Middle Aged, Organometallic Compounds/pharmacokinetics, Pneumonia, Viral/blood, Respiration, Artificial, Respiratory Distress Syndrome/blood, Transferrin/pharmacokinetics, Virulence, Virus Activation",

author = "Joanne Verheij and Groeneveld, \{A. B.Johan\} and Albertus Beishuizen and \{van Lingen\}, Arthur and Simoons-Smit, \{Alberdina M.\} and \{van Schijndel\}, \{Rob J.M.Strack\}",

year = "2004",

month = jun,

doi = "10.1186/cc2850",

language = "English",

volume = "8",

pages = "R139",

journal = "Critical care (London, England)",

issn = "1364-8535",

publisher = "BioMed Central Ltd.",

number = "3",

}

TY - JOUR

T1 - Herpes simplex virus type 1 and normal protein permeability in the lungs of critically ill patients

T2 - a case for low pathogenicity?

AU - Verheij, Joanne

AU - Groeneveld, A. B.Johan

AU - Beishuizen, Albertus

AU - van Lingen, Arthur

AU - Simoons-Smit, Alberdina M.

AU - van Schijndel, Rob J.M.Strack

PY - 2004/6

Y1 - 2004/6

N2 - INTRODUCTION: The pathogenicity of late respiratory infections with herpes simplex virus type 1 (HSV-1) in the critically ill is unclear.METHODS: In four critically ill patients with persistent pulmonary infiltrates of unknown origin and isolation of HSV-1 from tracheal aspirate or bronchoalveolar lavage fluid, at 7 (1-11) days after start of mechanical ventilatory support, a pulmonary leak index (PLI) for 67Gallium (67Ga)-transferrin (upper limit of normal 14.1 x 10(-3)/min) was measured.RESULTS: The PLI ranged between 7.5 and 14.0 x 10(-3)/min in the study patients. Two patients received a course of acyclovir and all survived.CONCLUSIONS: The normal capillary permeability observed in the lungs argues against pathogenicity of HSV-1 in the critically ill, and favors that isolation of the virus reflects reactivation in the course of serious illness and immunodepresssion, rather than primary or superimposed infection in the lungs.

AB - INTRODUCTION: The pathogenicity of late respiratory infections with herpes simplex virus type 1 (HSV-1) in the critically ill is unclear.METHODS: In four critically ill patients with persistent pulmonary infiltrates of unknown origin and isolation of HSV-1 from tracheal aspirate or bronchoalveolar lavage fluid, at 7 (1-11) days after start of mechanical ventilatory support, a pulmonary leak index (PLI) for 67Gallium (67Ga)-transferrin (upper limit of normal 14.1 x 10(-3)/min) was measured.RESULTS: The PLI ranged between 7.5 and 14.0 x 10(-3)/min in the study patients. Two patients received a course of acyclovir and all survived.CONCLUSIONS: The normal capillary permeability observed in the lungs argues against pathogenicity of HSV-1 in the critically ill, and favors that isolation of the virus reflects reactivation in the course of serious illness and immunodepresssion, rather than primary or superimposed infection in the lungs.

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KW - Aged

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KW - Critical Illness

KW - Female

KW - Gallium Radioisotopes/pharmacokinetics

KW - Herpesvirus 1, Human/isolation & purification

KW - Humans

KW - Male

KW - Middle Aged

KW - Organometallic Compounds/pharmacokinetics

KW - Pneumonia, Viral/blood

KW - Respiration, Artificial

KW - Respiratory Distress Syndrome/blood

KW - Transferrin/pharmacokinetics

KW - Virulence

KW - Virus Activation

UR - https://www.scopus.com/pages/publications/21644455950

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DO - 10.1186/cc2850

M3 - Article

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SN - 1364-8535

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JO - Critical care (London, England)

JF - Critical care (London, England)

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ER -

Herpes simplex virus type 1 and normal protein permeability in the lungs of critically ill patients: a case for low pathogenicity?

Abstract

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Keywords

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