Hepatitis E infection with a benign course during vedolizumab treatment for Crohn's disease: A case report: Hepatitis E during vedolizumab therapy in IBD

R. L. Goetgebuer; G. M. C. Masclee; A. A. van der Eijk; C. J. van der Woude; R. A. de Man; A. C. de Vries

doi:10.1016/j.clinre.2022.101948

Hepatitis E infection with a benign course during vedolizumab treatment for Crohn's disease: A case report: Hepatitis E during vedolizumab therapy in IBD

R. L. Goetgebuer^*
, G. M. C. Masclee
, A. A. van der Eijk
, C. J. van der Woude
, R. A. de Man
, A. C. de Vries

^*Corresponding author for this work

Erasmus MC

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

We present a 49 year old female patient with Crohn's disease (CD) in remission on vedolizumab therapy who experienced a symptomatic, though benign, course of acute hepatitis E. Routine blood tests showed substantial elevation of liver enzymes and polymerase chain reaction (PCR) testing confirmed hepatitis E virus (HEV) infection. Vedolizumab therapy was paused, liver enzymes improved three weeks after infection and normalized after six months. The patient recovered completely from mild symptoms. This case shows that hepatitis E is a potential cause of acute hepatitis during vedolizumab therapy, and in this case the infection has run a benign course.

Original language	English
Article number	101948
Journal	Clinics and research in hepatology and gastroenterology
Volume	46
Issue number	7
DOIs	https://doi.org/10.1016/j.clinre.2022.101948
Publication status	Published - 1 Aug 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Crohn's disease
Hepatitis E
IBD
Vedolizumab

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10.1016/j.clinre.2022.101948

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Goetgebuer, R. L., Masclee, G. M. C., van der Eijk, A. A., van der Woude, C. J., de Man, R. A., & de Vries, A. C. (2022). Hepatitis E infection with a benign course during vedolizumab treatment for Crohn's disease: A case report: Hepatitis E during vedolizumab therapy in IBD. Clinics and research in hepatology and gastroenterology, 46(7), Article 101948. https://doi.org/10.1016/j.clinre.2022.101948

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title = "Hepatitis E infection with a benign course during vedolizumab treatment for Crohn's disease: A case report: Hepatitis E during vedolizumab therapy in IBD",

abstract = "We present a 49 year old female patient with Crohn's disease (CD) in remission on vedolizumab therapy who experienced a symptomatic, though benign, course of acute hepatitis E. Routine blood tests showed substantial elevation of liver enzymes and polymerase chain reaction (PCR) testing confirmed hepatitis E virus (HEV) infection. Vedolizumab therapy was paused, liver enzymes improved three weeks after infection and normalized after six months. The patient recovered completely from mild symptoms. This case shows that hepatitis E is a potential cause of acute hepatitis during vedolizumab therapy, and in this case the infection has run a benign course.",

keywords = "Crohn's disease, Hepatitis E, IBD, Vedolizumab",

author = "Goetgebuer, \{R. L.\} and Masclee, \{G. M. C.\} and \{van der Eijk\}, \{A. A.\} and \{van der Woude\}, \{C. J.\} and \{de Man\}, \{R. A.\} and \{de Vries\}, \{A. C.\}",

note = "Funding Information: This research did not receive any specific funding from agencies in the public, commercial of non-profit sectors. We would like to thank the patient of this case report. She gave us permission to write down her disease course and she was very helpful in sharing her patient history. We did not receive any funding for this study. We would like to thank Kabir Paul Ravindra for checking English grammar and syntax. Publisher Copyright: {\textcopyright} 2022 The Author(s)",

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Goetgebuer, RL, Masclee, GMC, van der Eijk, AA, van der Woude, CJ, de Man, RA & de Vries, AC 2022, 'Hepatitis E infection with a benign course during vedolizumab treatment for Crohn's disease: A case report: Hepatitis E during vedolizumab therapy in IBD', Clinics and research in hepatology and gastroenterology, vol. 46, no. 7, 101948. https://doi.org/10.1016/j.clinre.2022.101948

Hepatitis E infection with a benign course during vedolizumab treatment for Crohn's disease: A case report: Hepatitis E during vedolizumab therapy in IBD. / Goetgebuer, R. L.; Masclee, G. M. C.; van der Eijk, A. A. et al.
In: Clinics and research in hepatology and gastroenterology, Vol. 46, No. 7, 101948, 01.08.2022.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Hepatitis E infection with a benign course during vedolizumab treatment for Crohn's disease

T2 - A case report: Hepatitis E during vedolizumab therapy in IBD

AU - Goetgebuer, R. L.

AU - Masclee, G. M. C.

AU - van der Eijk, A. A.

AU - van der Woude, C. J.

AU - de Man, R. A.

AU - de Vries, A. C.

N1 - Funding Information: This research did not receive any specific funding from agencies in the public, commercial of non-profit sectors. We would like to thank the patient of this case report. She gave us permission to write down her disease course and she was very helpful in sharing her patient history. We did not receive any funding for this study. We would like to thank Kabir Paul Ravindra for checking English grammar and syntax. Publisher Copyright: © 2022 The Author(s)

PY - 2022/8/1

Y1 - 2022/8/1

N2 - We present a 49 year old female patient with Crohn's disease (CD) in remission on vedolizumab therapy who experienced a symptomatic, though benign, course of acute hepatitis E. Routine blood tests showed substantial elevation of liver enzymes and polymerase chain reaction (PCR) testing confirmed hepatitis E virus (HEV) infection. Vedolizumab therapy was paused, liver enzymes improved three weeks after infection and normalized after six months. The patient recovered completely from mild symptoms. This case shows that hepatitis E is a potential cause of acute hepatitis during vedolizumab therapy, and in this case the infection has run a benign course.

AB - We present a 49 year old female patient with Crohn's disease (CD) in remission on vedolizumab therapy who experienced a symptomatic, though benign, course of acute hepatitis E. Routine blood tests showed substantial elevation of liver enzymes and polymerase chain reaction (PCR) testing confirmed hepatitis E virus (HEV) infection. Vedolizumab therapy was paused, liver enzymes improved three weeks after infection and normalized after six months. The patient recovered completely from mild symptoms. This case shows that hepatitis E is a potential cause of acute hepatitis during vedolizumab therapy, and in this case the infection has run a benign course.

KW - Crohn's disease

KW - Hepatitis E

KW - IBD

KW - Vedolizumab

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JO - Clinics and research in hepatology and gastroenterology

JF - Clinics and research in hepatology and gastroenterology

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ER -

Hepatitis E infection with a benign course during vedolizumab treatment for Crohn's disease: A case report: Hepatitis E during vedolizumab therapy in IBD

Abstract

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Keywords

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