Glucocorticoids and relapse of major depression (dexamethasone/corticotropin-releasing hormone test in relation to relapse of major depression)

Bente C. Appelhof; Jochanan Huyser; Mijke Verweij; Jantien P. Brouwer; Richard van Dyck; Eric Fliers; Witte J. G. Hoogendijk; Jan G. P. Tijssen; Wilmar M. Wiersinga; Aart H. Schene

doi:10.1016/j.biopsych.2005.09.008

Glucocorticoids and relapse of major depression (dexamethasone/corticotropin-releasing hormone test in relation to relapse of major depression)

Bente C. Appelhof
, Jochanan Huyser
, Mijke Verweij
, Jantien P. Brouwer
, Richard van Dyck
, Eric Fliers
, Witte J. G. Hoogendijk
, Jan G. P. Tijssen
, Wilmar M. Wiersinga
, Aart H. Schene

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Knowledge of pathogenic mechanisms and predictors of relapse in major depressive disorder is still limited. Hypothalamic-pituitary-adrenocortical (HPA) axis dysregulation is thought to be related to the development and course of depression. METHODS: We investigated whether dexamethasone/corticotropin-releasing hormone (DEX/CRH) test parameters were related to the occurrence of relapse in 45 outpatients with clinically remitted major depression. The DEX/CRH test was administered before and after 8 weeks of antidepressant treatment. RESULTS: Posttreatment maximal adrenocorticotropic hormone (ACTH) and maximal cortisol levels, as well as delta ACTH and delta cortisol levels, were significantly higher (all p < .05) among patients who relapsed (n = 22) compared with patients in whom no relapse occurred (n = 23). Higher posttreatment maximal cortisol response on the DEX/CRH test was associated with shorter "relapse-free survival" (p = .05). CONCLUSIONS: In outpatients with clinically remitted major depression, higher posttreatment maximal cortisol levels on the DEX/CRH test were associated with relapse of major depression

Original language	English
Pages (from-to)	696-701
Journal	Biological psychiatry
Volume	59
Issue number	8
DOIs	https://doi.org/10.1016/j.biopsych.2005.09.008
Publication status	Published - 2006

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10.1016/j.biopsych.2005.09.008

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Appelhof, B. C., Huyser, J., Verweij, M., Brouwer, J. P., van Dyck, R., Fliers, E., Hoogendijk, W. J. G., Tijssen, J. G. P., Wiersinga, W. M., & Schene, A. H. (2006). Glucocorticoids and relapse of major depression (dexamethasone/corticotropin-releasing hormone test in relation to relapse of major depression). Biological psychiatry, 59(8), 696-701. https://doi.org/10.1016/j.biopsych.2005.09.008

@article{635c7942cd2948b487d0c2325c5585ba,

title = "Glucocorticoids and relapse of major depression (dexamethasone/corticotropin-releasing hormone test in relation to relapse of major depression)",

abstract = "BACKGROUND: Knowledge of pathogenic mechanisms and predictors of relapse in major depressive disorder is still limited. Hypothalamic-pituitary-adrenocortical (HPA) axis dysregulation is thought to be related to the development and course of depression. METHODS: We investigated whether dexamethasone/corticotropin-releasing hormone (DEX/CRH) test parameters were related to the occurrence of relapse in 45 outpatients with clinically remitted major depression. The DEX/CRH test was administered before and after 8 weeks of antidepressant treatment. RESULTS: Posttreatment maximal adrenocorticotropic hormone (ACTH) and maximal cortisol levels, as well as delta ACTH and delta cortisol levels, were significantly higher (all p < .05) among patients who relapsed (n = 22) compared with patients in whom no relapse occurred (n = 23). Higher posttreatment maximal cortisol response on the DEX/CRH test was associated with shorter {"}relapse-free survival{"} (p = .05). CONCLUSIONS: In outpatients with clinically remitted major depression, higher posttreatment maximal cortisol levels on the DEX/CRH test were associated with relapse of major depression",

author = "Appelhof, \{Bente C.\} and Jochanan Huyser and Mijke Verweij and Brouwer, \{Jantien P.\} and \{van Dyck\}, Richard and Eric Fliers and Hoogendijk, \{Witte J. G.\} and Tijssen, \{Jan G. P.\} and Wiersinga, \{Wilmar M.\} and Schene, \{Aart H.\}",

year = "2006",

doi = "10.1016/j.biopsych.2005.09.008",

language = "English",

volume = "59",

pages = "696--701",

journal = "Biological psychiatry",

issn = "0006-3223",

publisher = "Elsevier USA",

number = "8",

}

Appelhof, BC, Huyser, J, Verweij, M, Brouwer, JP, van Dyck, R, Fliers, E, Hoogendijk, WJG, Tijssen, JGP, Wiersinga, WM & Schene, AH 2006, 'Glucocorticoids and relapse of major depression (dexamethasone/corticotropin-releasing hormone test in relation to relapse of major depression)', Biological psychiatry, vol. 59, no. 8, pp. 696-701. https://doi.org/10.1016/j.biopsych.2005.09.008

TY - JOUR

T1 - Glucocorticoids and relapse of major depression (dexamethasone/corticotropin-releasing hormone test in relation to relapse of major depression)

AU - Appelhof, Bente C.

AU - Huyser, Jochanan

AU - Verweij, Mijke

AU - Brouwer, Jantien P.

AU - van Dyck, Richard

AU - Fliers, Eric

AU - Hoogendijk, Witte J. G.

AU - Tijssen, Jan G. P.

AU - Wiersinga, Wilmar M.

AU - Schene, Aart H.

PY - 2006

Y1 - 2006

N2 - BACKGROUND: Knowledge of pathogenic mechanisms and predictors of relapse in major depressive disorder is still limited. Hypothalamic-pituitary-adrenocortical (HPA) axis dysregulation is thought to be related to the development and course of depression. METHODS: We investigated whether dexamethasone/corticotropin-releasing hormone (DEX/CRH) test parameters were related to the occurrence of relapse in 45 outpatients with clinically remitted major depression. The DEX/CRH test was administered before and after 8 weeks of antidepressant treatment. RESULTS: Posttreatment maximal adrenocorticotropic hormone (ACTH) and maximal cortisol levels, as well as delta ACTH and delta cortisol levels, were significantly higher (all p < .05) among patients who relapsed (n = 22) compared with patients in whom no relapse occurred (n = 23). Higher posttreatment maximal cortisol response on the DEX/CRH test was associated with shorter "relapse-free survival" (p = .05). CONCLUSIONS: In outpatients with clinically remitted major depression, higher posttreatment maximal cortisol levels on the DEX/CRH test were associated with relapse of major depression

AB - BACKGROUND: Knowledge of pathogenic mechanisms and predictors of relapse in major depressive disorder is still limited. Hypothalamic-pituitary-adrenocortical (HPA) axis dysregulation is thought to be related to the development and course of depression. METHODS: We investigated whether dexamethasone/corticotropin-releasing hormone (DEX/CRH) test parameters were related to the occurrence of relapse in 45 outpatients with clinically remitted major depression. The DEX/CRH test was administered before and after 8 weeks of antidepressant treatment. RESULTS: Posttreatment maximal adrenocorticotropic hormone (ACTH) and maximal cortisol levels, as well as delta ACTH and delta cortisol levels, were significantly higher (all p < .05) among patients who relapsed (n = 22) compared with patients in whom no relapse occurred (n = 23). Higher posttreatment maximal cortisol response on the DEX/CRH test was associated with shorter "relapse-free survival" (p = .05). CONCLUSIONS: In outpatients with clinically remitted major depression, higher posttreatment maximal cortisol levels on the DEX/CRH test were associated with relapse of major depression

U2 - 10.1016/j.biopsych.2005.09.008

DO - 10.1016/j.biopsych.2005.09.008

M3 - Article

C2 - 16368077

SN - 0006-3223

VL - 59

SP - 696

EP - 701

JO - Biological psychiatry

JF - Biological psychiatry

IS - 8

ER -

Glucocorticoids and relapse of major depression (dexamethasone/corticotropin-releasing hormone test in relation to relapse of major depression)

Abstract

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