Glucagon-Like Peptide-1 Receptor Agonists: Beta-Cell Protection or Exhaustion?

Daniël H van Raalte; C Bruce Verchere

doi:10.1016/j.tem.2016.04.009

Glucagon-Like Peptide-1 Receptor Agonists: Beta-Cell Protection or Exhaustion?

Daniël H van Raalte
, C Bruce Verchere

Department of Pathology and Laboratory Medicine, Child and Family Research Institute, The University of British Columbia, Vancouver, Canada; Department of Surgery, Child and Family Research Institute, The University of British Columbia, Vancouver, Canada.

Research output: Contribution to journal › Short survey › Academic › peer-review

Abstract

Glucagon-like peptide (GLP)-1 receptor agonists enhance insulin secretion and may improve pancreatic islet cell function. However, GLP-1 receptor (GLP-1R) agonist treatment may have more complex, and sometimes deleterious, effects on beta cells. We discuss the concepts of beta cell protection versus exhaustion for different GLP-1R agonists based on recent data.

Original language	English
Pages (from-to)	442-5
Number of pages	4
Journal	TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume	27
Issue number	7
DOIs	https://doi.org/10.1016/j.tem.2016.04.009
Publication status	Published - Jul 2016

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Journal Article

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10.1016/j.tem.2016.04.009

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title = "Glucagon-Like Peptide-1 Receptor Agonists: Beta-Cell Protection or Exhaustion?",

abstract = "Glucagon-like peptide (GLP)-1 receptor agonists enhance insulin secretion and may improve pancreatic islet cell function. However, GLP-1 receptor (GLP-1R) agonist treatment may have more complex, and sometimes deleterious, effects on beta cells. We discuss the concepts of beta cell protection versus exhaustion for different GLP-1R agonists based on recent data.",

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year = "2016",

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TY - JOUR

T1 - Glucagon-Like Peptide-1 Receptor Agonists

T2 - Beta-Cell Protection or Exhaustion?

AU - van Raalte, Daniël H

AU - Verchere, C Bruce

PY - 2016/7

Y1 - 2016/7

N2 - Glucagon-like peptide (GLP)-1 receptor agonists enhance insulin secretion and may improve pancreatic islet cell function. However, GLP-1 receptor (GLP-1R) agonist treatment may have more complex, and sometimes deleterious, effects on beta cells. We discuss the concepts of beta cell protection versus exhaustion for different GLP-1R agonists based on recent data.

AB - Glucagon-like peptide (GLP)-1 receptor agonists enhance insulin secretion and may improve pancreatic islet cell function. However, GLP-1 receptor (GLP-1R) agonist treatment may have more complex, and sometimes deleterious, effects on beta cells. We discuss the concepts of beta cell protection versus exhaustion for different GLP-1R agonists based on recent data.

KW - Journal Article

U2 - 10.1016/j.tem.2016.04.009

DO - 10.1016/j.tem.2016.04.009

M3 - Short survey

SN - 1043-2760

VL - 27

SP - 442

EP - 445

JO - TRENDS IN ENDOCRINOLOGY AND METABOLISM

JF - TRENDS IN ENDOCRINOLOGY AND METABOLISM

IS - 7

ER -

Glucagon-Like Peptide-1 Receptor Agonists: Beta-Cell Protection or Exhaustion?

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