Germ cell specific gene expression in cancer

J.W. Bruggeman

Germ cell specific gene expression in cancer

J.W. Bruggeman

Research output: PhD Thesis › Phd-Thesis - Research and graduation internal

Abstract

We have found that over one thousand genes are exclusively expressed in germ cells and cancer cells, suggesting many shared properties between these cell types. In particular, many genes involved in meiosis are expressed in cancer, likely allowing a cancer cell to repair DNA through semimeiotic recombination. By using the shared properties of cancer and germline cells, we can gain a better understanding of oncogenesis and develop new anticancer therapies that have limited side effects.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	University of Amsterdam
Supervisors/Advisors	van Pelt, Ans M.M., Supervisor Hamer, Geert, Supervisor Koster, Jan, Co-supervisor
Award date	27 Feb 2024
Publication status	Published - 27 Feb 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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https://hdl.handle.net/11245.1/b6e5f598-3a82-486f-9685-e3c168fa9571

Cite this

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title = "Germ cell specific gene expression in cancer",

abstract = "We have found that over one thousand genes are exclusively expressed in germ cells and cancer cells, suggesting many shared properties between these cell types. In particular, many genes involved in meiosis are expressed in cancer, likely allowing a cancer cell to repair DNA through semimeiotic recombination. By using the shared properties of cancer and germline cells, we can gain a better understanding of oncogenesis and develop new anticancer therapies that have limited side effects.",

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year = "2024",

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AU - Bruggeman, J.W.

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N2 - We have found that over one thousand genes are exclusively expressed in germ cells and cancer cells, suggesting many shared properties between these cell types. In particular, many genes involved in meiosis are expressed in cancer, likely allowing a cancer cell to repair DNA through semimeiotic recombination. By using the shared properties of cancer and germline cells, we can gain a better understanding of oncogenesis and develop new anticancer therapies that have limited side effects.

AB - We have found that over one thousand genes are exclusively expressed in germ cells and cancer cells, suggesting many shared properties between these cell types. In particular, many genes involved in meiosis are expressed in cancer, likely allowing a cancer cell to repair DNA through semimeiotic recombination. By using the shared properties of cancer and germline cells, we can gain a better understanding of oncogenesis and develop new anticancer therapies that have limited side effects.

M3 - Phd-Thesis - Research and graduation internal

ER -

Germ cell specific gene expression in cancer

Abstract

UN SDGs

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