Genomic characterization of Citrobacter freundii clinical isolates from Tanzania

Gerald Mboowa; Benson R. Kidenya; Ivan Sserwadda; Stephen Kanyerezi; Inyasi Lawrence Akaro; Baraka Mkinze; Jeremiah Seni

doi:10.1128/mra.00363-25

Genomic characterization of Citrobacter freundii clinical isolates from Tanzania

Gerald Mboowa^*
, Benson R. Kidenya^*
, Ivan Sserwadda
, Stephen Kanyerezi
, Inyasi Lawrence Akaro
, Baraka Mkinze
, Jeremiah Seni

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

We report draft genomes of three Citrobacter freundii isolates from Tanzania. Genomes averaged 6.9 Mb with 51.49% GC content and 114× depth. ST167 carried multiple extended-spectrum β-lactamase, fluoroquinolone, and aminoglycoside resistance genes alongside virulence factors, highlighting the need for genomic surveillance of emerging multidrug-resistant C. freundii lineages.

Original language	English
Journal	Microbiology Resource Announcements
Volume	14
Issue number	8
DOIs	https://doi.org/10.1128/mra.00363-25
Publication status	Published - 1 Aug 2025
Externally published	Yes

Keywords

Citrobacter freundii
antimicrobial resistance (AMR)
genomic surveillance
virulence factors
whole-genome sequencing

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Genomic-characterization-of-citrobacter-freundii-clinical-isolates-from-tanzania.pdfFinal published version, 854 KBLicence: CC BY

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title = "Genomic characterization of Citrobacter freundii clinical isolates from Tanzania",

abstract = "We report draft genomes of three Citrobacter freundii isolates from Tanzania. Genomes averaged 6.9 Mb with 51.49\% GC content and 114× depth. ST167 carried multiple extended-spectrum β-lactamase, fluoroquinolone, and aminoglycoside resistance genes alongside virulence factors, highlighting the need for genomic surveillance of emerging multidrug-resistant C. freundii lineages.",

keywords = "Citrobacter freundii, antimicrobial resistance (AMR), genomic surveillance, virulence factors, whole-genome sequencing",

author = "Gerald Mboowa and Kidenya, \{Benson R.\} and Ivan Sserwadda and Stephen Kanyerezi and Akaro, \{Inyasi Lawrence\} and Baraka Mkinze and Jeremiah Seni",

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AU - Mboowa, Gerald

AU - Kidenya, Benson R.

AU - Sserwadda, Ivan

AU - Kanyerezi, Stephen

AU - Akaro, Inyasi Lawrence

AU - Mkinze, Baraka

AU - Seni, Jeremiah

PY - 2025/8/1

Y1 - 2025/8/1

N2 - We report draft genomes of three Citrobacter freundii isolates from Tanzania. Genomes averaged 6.9 Mb with 51.49% GC content and 114× depth. ST167 carried multiple extended-spectrum β-lactamase, fluoroquinolone, and aminoglycoside resistance genes alongside virulence factors, highlighting the need for genomic surveillance of emerging multidrug-resistant C. freundii lineages.

AB - We report draft genomes of three Citrobacter freundii isolates from Tanzania. Genomes averaged 6.9 Mb with 51.49% GC content and 114× depth. ST167 carried multiple extended-spectrum β-lactamase, fluoroquinolone, and aminoglycoside resistance genes alongside virulence factors, highlighting the need for genomic surveillance of emerging multidrug-resistant C. freundii lineages.

KW - Citrobacter freundii

KW - antimicrobial resistance (AMR)

KW - genomic surveillance

KW - virulence factors

KW - whole-genome sequencing

UR - https://www.scopus.com/pages/publications/105013500950

U2 - 10.1128/mra.00363-25

DO - 10.1128/mra.00363-25

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SN - 2576-098X

VL - 14

JO - Microbiology Resource Announcements

JF - Microbiology Resource Announcements

IS - 8

ER -

Genomic characterization of Citrobacter freundii clinical isolates from Tanzania

Abstract

Keywords

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