Genetically-informed patient selection for iPSC studies of complex diseases may aid in reducing cellular heterogeneity

Stephanie D. Hoekstra; Sven Stringer; Vivi M. Heine; Danielle Posthuma

doi:10.3389/fncel.2017.00164

Genetically-informed patient selection for iPSC studies of complex diseases may aid in reducing cellular heterogeneity

Stephanie D. Hoekstra
, Sven Stringer
, Vivi M. Heine
, Danielle Posthuma^*

^*Corresponding author for this work

Vrije Universiteit Amsterdam
VU University Amsterdam
VU University

Research output: Contribution to journal › Article › Academic › peer-review

14 Downloads (Pure)

Abstract

Induced pluripotent stem cell (iPSC) technology is more and more used for the study of genetically complex human disease but is challenged by variability, sample size and polygenicity. We discuss studies involving iPSC-derived neurons from patients with Schizophrenia (SCZ), to exemplify that heterogeneity in sampling strategy complicate the detection of disease mechanisms. We offer a solution to controlling variability within and between iPSC studies by using specific patient selection strategies.

Original language	English
Article number	164
Journal	Frontiers in cellular neuroscience
Volume	11
DOIs	https://doi.org/10.3389/fncel.2017.00164
Publication status	Published - 13 Jun 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Disease models
Genetics
IPSC
Psychiatric diseases
Schizophrenia
Statistical power
Stem cells
Variability

Access to Document

10.3389/fncel.2017.00164

Genetically-informed-patient-selection-for-ipsc-studies-of-complex-diseases-may-aid-in-reducing-cellular-heterogeneity.pdfFinal published version, 641 KBLicence: Taverne

Cite this

@article{cb50d683b51842a091843fa814d7e662,

title = "Genetically-informed patient selection for iPSC studies of complex diseases may aid in reducing cellular heterogeneity",

abstract = "Induced pluripotent stem cell (iPSC) technology is more and more used for the study of genetically complex human disease but is challenged by variability, sample size and polygenicity. We discuss studies involving iPSC-derived neurons from patients with Schizophrenia (SCZ), to exemplify that heterogeneity in sampling strategy complicate the detection of disease mechanisms. We offer a solution to controlling variability within and between iPSC studies by using specific patient selection strategies.",

keywords = "Disease models, Genetics, IPSC, Psychiatric diseases, Schizophrenia, Statistical power, Stem cells, Variability",

author = "Hoekstra, \{Stephanie D.\} and Sven Stringer and Heine, \{Vivi M.\} and Danielle Posthuma",

year = "2017",

month = jun,

day = "13",

doi = "10.3389/fncel.2017.00164",

language = "English",

volume = "11",

journal = "Frontiers in cellular neuroscience",

issn = "1662-5102",

publisher = "Frontiers Media S.A.",

}

TY - JOUR

T1 - Genetically-informed patient selection for iPSC studies of complex diseases may aid in reducing cellular heterogeneity

AU - Hoekstra, Stephanie D.

AU - Stringer, Sven

AU - Heine, Vivi M.

AU - Posthuma, Danielle

PY - 2017/6/13

Y1 - 2017/6/13

N2 - Induced pluripotent stem cell (iPSC) technology is more and more used for the study of genetically complex human disease but is challenged by variability, sample size and polygenicity. We discuss studies involving iPSC-derived neurons from patients with Schizophrenia (SCZ), to exemplify that heterogeneity in sampling strategy complicate the detection of disease mechanisms. We offer a solution to controlling variability within and between iPSC studies by using specific patient selection strategies.

AB - Induced pluripotent stem cell (iPSC) technology is more and more used for the study of genetically complex human disease but is challenged by variability, sample size and polygenicity. We discuss studies involving iPSC-derived neurons from patients with Schizophrenia (SCZ), to exemplify that heterogeneity in sampling strategy complicate the detection of disease mechanisms. We offer a solution to controlling variability within and between iPSC studies by using specific patient selection strategies.

KW - Disease models

KW - Genetics

KW - IPSC

KW - Psychiatric diseases

KW - Schizophrenia

KW - Statistical power

KW - Stem cells

KW - Variability

UR - https://www.scopus.com/pages/publications/85021682256

U2 - 10.3389/fncel.2017.00164

DO - 10.3389/fncel.2017.00164

M3 - Article

C2 - 28659762

SN - 1662-5102

VL - 11

JO - Frontiers in cellular neuroscience

JF - Frontiers in cellular neuroscience

M1 - 164

ER -

Genetically-informed patient selection for iPSC studies of complex diseases may aid in reducing cellular heterogeneity

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this