Genetic variants linked to education predict longevity

A. Okbay; S. J. van der Lee; G. Davies; P. K. Joshi; D. C. Liewald; R. E. Marioni; D. J. Porteous; C. Hayward; J. F. Wilson; G. D. Smith; J. Yang

doi:10.1073/pnas.1605334113

Genetic variants linked to education predict longevity

A. Okbay
, S. J. van der Lee
, G. Davies
, P. K. Joshi
, D. C. Liewald
, R. E. Marioni^*
, D. J. Porteous
, C. Hayward
, J. F. Wilson
, G. D. Smith
, J. Yang

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

12 Downloads (Pure)

Abstract

Educational attainment is associated with many health outcomes, including longevity. It is also known to be substantially heritable. Here, we used data from three large genetic epidemiology cohort studies (Generation Scotland, n = ∼17,000; UK Biobank, n = ∼115,000; and the Estonian Biobank, n = ∼6,000) to test whether education-linked genetic variants can predict lifespan length. We did so by using cohort members' polygenic profile score for education to predict their parents' longevity. Across the three cohorts, meta-analysis showed that a 1 SD higher polygenic education score was associated with ∼2.7% lower mortality risk for both mothers (total n_deaths= 79,702) and ∼2.4% lower risk for fathers (total n_deaths= 97,630). On average, the parents of offspring in the upper third of the polygenic score distribution lived 0.55 y longer compared with those of offspring in the lower third. Overall, these results indicate that the genetic contributions to educational attainment are useful in the prediction of human longevity.

Original language	English
Pages (from-to)	13366-13371
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	113
Issue number	47
DOIs	https://doi.org/10.1073/pnas.1605334113
Publication status	Published - 22 Nov 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Education
Genetics
Longevity
Polygenic score
Prediction

Access to Document

10.1073/pnas.1605334113

Genetic-variants-linked-to-education-predict-longevity.pdfFinal published version, 657 KBLicence: CC BY

Cite this

@article{5e5649e45f0842fcbd82e83da8a6140c,

title = "Genetic variants linked to education predict longevity",

abstract = "Educational attainment is associated with many health outcomes, including longevity. It is also known to be substantially heritable. Here, we used data from three large genetic epidemiology cohort studies (Generation Scotland, n = ∼17,000; UK Biobank, n = ∼115,000; and the Estonian Biobank, n = ∼6,000) to test whether education-linked genetic variants can predict lifespan length. We did so by using cohort members' polygenic profile score for education to predict their parents' longevity. Across the three cohorts, meta-analysis showed that a 1 SD higher polygenic education score was associated with ∼2.7\% lower mortality risk for both mothers (total ndeaths= 79,702) and ∼2.4\% lower risk for fathers (total ndeaths= 97,630). On average, the parents of offspring in the upper third of the polygenic score distribution lived 0.55 y longer compared with those of offspring in the lower third. Overall, these results indicate that the genetic contributions to educational attainment are useful in the prediction of human longevity.",

keywords = "Education, Genetics, Longevity, Polygenic score, Prediction",

author = "Marioni, \{R. E.\} and Ritchie, \{S. J.\} and Joshi, \{P. K.\} and Hagenaars, \{S. P.\} and A. Okbay and K. Fischer and Adams, \{M. J.\} and Hill, \{W. D.\} and G. Davies and R. Nagy and C. Amador and K. L{\"a}ll and A. Metspalu and Liewald, \{D. C.\} and A. Campbell and Wilson, \{J. F.\} and C. Hayward and T. Esko and Porteous, \{D. J.\} and Gale, \{C. R.\} and Deary, \{I. J.\} and A. Okbay and Beauchamp, \{J. P.\} and Fontana, \{M. A.\} and Lee, \{J. J.\} and Pers, \{T. H.\} and Rietveld, \{C. A.\} and P. Turley and Chen, \{G. B.\} and V. Emilsson and Meddens, \{S. F.\} and S. Oskarsson and Pickrell, \{J. K.\} and K. Thom and P. Timshel and \{de Vlaming\}, R. and A. Abdellaoui and Ahluwalia, \{T. S.\} and J. Bacelis and C. Baumbach and G. Bjornsdottir and Brandsma, \{J. H.\} and Concas, \{M. P.\} and J. Derringer and Furlotte, \{N. A.\} and Galesloot, \{T. E.\} and G. Girotto and R. Gupta and Hall, \{L. M.\} and Harris, \{S. E.\} and E. Hofer and M. Horikoshi and Huffman, \{J. E.\} and K. Kaasik and Kalafati, \{I. P.\} and R. Karlsson and A. Kong and J. Lahti and \{van der Lee\}, \{S. J.\} and \{de Leeuw\}, C. and Lind, \{P. A.\} and Lindgren, \{K. O.\} and T. Liu and M. Mangino and J. Marten and E. Mihailov and Miller, \{M. B.\} and \{van der Most\}, \{P. J.\} and C. Oldmeadow and A. Payton and N. Pervjakova and Peyrot, \{W. J.\} and Y. Qian and O. Raitakari and R. Rueedi and E. Salvi and B. Schmidt and Schraut, \{K. E.\} and J. Shi and Smith, \{A. V.\} and Poot, \{R. A.\} and \{St Pourcain\}, B. and A. Teumer and G. Thorleifsson and N. Verweij and D. Vuckovic and J. Wellmann and Westra, \{H. J.\} and J. Yang and W. Zhao and Z. Zhu and Alizadeh, \{B. Z.\} and N. Amin and A. Bakshi and Baumeister, \{S. E.\} and G. Biino and K. B{\o}nnelykke and Boyle, \{P. A.\} and H. Campbell and Cappuccio, \{F. P.\} and G. Davies and \{De Neve\}, \{J. E.\} and P. Deloukas and I. Demuth and J. Ding and P. Eibich and L. Eisele and N. Eklund and Evans, \{D. M.\} and Faul, \{J. D.\} and Feitosa, \{M. F.\} and Forstner, \{A. J.\} and I. Gandin and B. Gunnarsson and Halld{\'o}rsson, \{B. V.\} and Harris, \{T. B.\} and Heath, \{A. C.\} and Hocking, \{L. J.\} and Holliday, \{E. G.\} and G. Homuth and Horan, \{M. A.\} and Hottenga, \{J. J.\} and \{de Jager\}, \{P. L.\} and Joshi, \{P. K.\} and A. Jugessur and Kaakinen, \{M. A.\} and M. K{\"a}h{\"o}nen and S. Kanoni and L. Keltigangas-J{\"a}rvinen and Kiemeney, \{L. A.\} and I. Kolcic and S. Koskinen and Kraja, \{A. T.\} and M. Kroh and Z. Kutalik and A. Latvala and Launer, \{L. J.\} and Lebreton, \{M. P.\} and Levinson, \{D. F.\} and P. Lichtenstein and P. Lichtner and Liewald, \{D. C.\} and A. Loukola and Madden, \{P. A.\} and R. M{\"a}gi and T. M{\"a}ki-Opas and Marioni, \{R. E.\} and P. Marques-Vidal and Meddens, \{G. A.\} and G. McMahon and C. Meisinger and T. Meitinger and Y. Milaneschi and L. Milani and Montgomery, \{G. W.\} and R. Myhre and Nelson, \{C. P.\} and Nyholt, \{D. R.\} and Ollier, \{W. E.\} and A. Palotie and L. Paternoster and Pedersen, \{N. L.\} and Petrovic, \{K. E.\} and Porteous, \{D. J.\} and K. R{\"a}ikk{\"o}nen and Ring, \{S. M.\} and A. Robino and O. Rostapshova and I. Rudan and A. Rustichini and V. Salomaa and Sanders, \{A. R.\} and Sarin, \{A. P.\} and H. Schmidt and Scott, \{R. J.\} and Smith, \{B. H.\} and Smith, \{J. A.\} and Staessen, \{J. A.\} and E. Steinhagen-Thiessen and K. Strauch and A. Terracciano and S. Ulivi and S. Vaccargiu and L. Quaye and \{van Rooij\}, \{F. J.\} and C. Venturini and Vinkhuyzen, \{A. A.\} and U. V{\"o}lker and H. V{\"o}lzke and Vonk, \{J. M.\} and D. Vozzi and J. Waage and Ware, \{E. B.\} and G. Willemsen and Attia, \{J. R.\} and Bennett, \{D. A.\} and K. Berger and L. Bertram and H. Bisgaard and Boomsma, \{D. I.\} and Borecki, \{I. B.\} and U. Bultmann and Chabris, \{C. F.\} and Francesco Cucca and D. Cusi and Dedoussis, \{G. V.\} and \{van Duijn\}, \{C. M.\} and Eriksson, \{J. G.\} and B. Franke and L. Franke and P. Gasparini and Gejman, \{P. V.\} and C. Gieger and Grabe, \{H. J.\} and J. Gratten and Groenen, \{P. J.\} and V. Gudnason and \{van der Harst\}, P. and C. Hayward and Hinds, \{D. A.\} and W. Hoffmann and E. Hypponen and Iacono, \{W. G.\} and B. Jacobsson and J{\"a}rvelin, \{M. R.\} and J{\"o}ckel, \{K. H.\} and J. Kaprio and Kardia, \{S. L.\} and T. Lehtim{\"a}ki and Lehrer, \{S. F.\} and Magnusson, \{P. K.\} and Martin, \{N. G.\} and M. McGue and N. Pendleton and Penninx, \{B. W.\} and M. Perola and N. Pirastu and M. Pirastu and O. Polasek and D. Posthuma and C. Power and Province, \{M. A.\} and Samani, \{N. J.\} and D. Schlessinger and R. Schmidt and S{\o}rensen, \{T. I.\} and Spector, \{T. D.\} and K. Stefansson and U. Thorsteinsdottir and Thurik, \{A. R.\} and Timpson, \{N. J.\} and H. Tiemeier and Tung, \{J. Y.\} and Uitterlinden, \{A. G.\} and V. Vitart and P. Vollenweider and Weir, \{D. R.\} and Wilson, \{J. F.\} and Wright, \{A. F.\} and Conley, \{D. C.\} and Krueger, \{R. F.\} and Smith, \{G. D.\} and A. Hofman and Laibson, \{D. I.\} and Medland, \{S. E.\} and Meyer, \{M. N.\} and J. Yang and M. Johannesson and Visscher, \{P. M.\} and Koellinger, \{P. D.\} and D. Cesarini and Benjamin, \{D. J.\}",

year = "2016",

month = nov,

day = "22",

doi = "10.1073/pnas.1605334113",

language = "English",

volume = "113",

pages = "13366--13371",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "47",

}

TY - JOUR

T1 - Genetic variants linked to education predict longevity

AU - Marioni, R. E.

AU - Ritchie, S. J.

AU - Joshi, P. K.

AU - Hagenaars, S. P.

AU - Okbay, A.

AU - Fischer, K.

AU - Adams, M. J.

AU - Hill, W. D.

AU - Davies, G.

AU - Nagy, R.

AU - Amador, C.

AU - Läll, K.

AU - Metspalu, A.

AU - Liewald, D. C.

AU - Campbell, A.

AU - Wilson, J. F.

AU - Hayward, C.

AU - Esko, T.

AU - Porteous, D. J.

AU - Gale, C. R.

AU - Deary, I. J.

AU - Okbay, A.

AU - Beauchamp, J. P.

AU - Fontana, M. A.

AU - Lee, J. J.

AU - Pers, T. H.

AU - Rietveld, C. A.

AU - Turley, P.

AU - Chen, G. B.

AU - Emilsson, V.

AU - Meddens, S. F.

AU - Oskarsson, S.

AU - Pickrell, J. K.

AU - Thom, K.

AU - Timshel, P.

AU - de Vlaming, R.

AU - Abdellaoui, A.

AU - Ahluwalia, T. S.

AU - Bacelis, J.

AU - Baumbach, C.

AU - Bjornsdottir, G.

AU - Brandsma, J. H.

AU - Concas, M. P.

AU - Derringer, J.

AU - Furlotte, N. A.

AU - Galesloot, T. E.

AU - Girotto, G.

AU - Gupta, R.

AU - Hall, L. M.

AU - Harris, S. E.

AU - Hofer, E.

AU - Horikoshi, M.

AU - Huffman, J. E.

AU - Kaasik, K.

AU - Kalafati, I. P.

AU - Karlsson, R.

AU - Kong, A.

AU - Lahti, J.

AU - van der Lee, S. J.

AU - de Leeuw, C.

AU - Lind, P. A.

AU - Lindgren, K. O.

AU - Liu, T.

AU - Mangino, M.

AU - Marten, J.

AU - Mihailov, E.

AU - Miller, M. B.

AU - van der Most, P. J.

AU - Oldmeadow, C.

AU - Payton, A.

AU - Pervjakova, N.

AU - Peyrot, W. J.

AU - Qian, Y.

AU - Raitakari, O.

AU - Rueedi, R.

AU - Salvi, E.

AU - Schmidt, B.

AU - Schraut, K. E.

AU - Shi, J.

AU - Smith, A. V.

AU - Poot, R. A.

AU - St Pourcain, B.

AU - Teumer, A.

AU - Thorleifsson, G.

AU - Verweij, N.

AU - Vuckovic, D.

AU - Wellmann, J.

AU - Westra, H. J.

AU - Yang, J.

AU - Zhao, W.

AU - Zhu, Z.

AU - Alizadeh, B. Z.

AU - Amin, N.

AU - Bakshi, A.

AU - Baumeister, S. E.

AU - Biino, G.

AU - Bønnelykke, K.

AU - Boyle, P. A.

AU - Campbell, H.

AU - Cappuccio, F. P.

AU - Davies, G.

AU - De Neve, J. E.

AU - Deloukas, P.

AU - Demuth, I.

AU - Ding, J.

AU - Eibich, P.

AU - Eisele, L.

AU - Eklund, N.

AU - Evans, D. M.

AU - Faul, J. D.

AU - Feitosa, M. F.

AU - Forstner, A. J.

AU - Gandin, I.

AU - Gunnarsson, B.

AU - Halldórsson, B. V.

AU - Harris, T. B.

AU - Heath, A. C.

AU - Hocking, L. J.

AU - Holliday, E. G.

AU - Homuth, G.

AU - Horan, M. A.

AU - Hottenga, J. J.

AU - de Jager, P. L.

AU - Joshi, P. K.

AU - Jugessur, A.

AU - Kaakinen, M. A.

AU - Kähönen, M.

AU - Kanoni, S.

AU - Keltigangas-Järvinen, L.

AU - Kiemeney, L. A.

AU - Kolcic, I.

AU - Koskinen, S.

AU - Kraja, A. T.

AU - Kroh, M.

AU - Kutalik, Z.

AU - Latvala, A.

AU - Launer, L. J.

AU - Lebreton, M. P.

AU - Levinson, D. F.

AU - Lichtenstein, P.

AU - Lichtner, P.

AU - Liewald, D. C.

AU - Loukola, A.

AU - Madden, P. A.

AU - Mägi, R.

AU - Mäki-Opas, T.

AU - Marioni, R. E.

AU - Marques-Vidal, P.

AU - Meddens, G. A.

AU - McMahon, G.

AU - Meisinger, C.

AU - Meitinger, T.

AU - Milaneschi, Y.

AU - Milani, L.

AU - Montgomery, G. W.

AU - Myhre, R.

AU - Nelson, C. P.

AU - Nyholt, D. R.

AU - Ollier, W. E.

AU - Palotie, A.

AU - Paternoster, L.

AU - Pedersen, N. L.

AU - Petrovic, K. E.

AU - Porteous, D. J.

AU - Räikkönen, K.

AU - Ring, S. M.

AU - Robino, A.

AU - Rostapshova, O.

AU - Rudan, I.

AU - Rustichini, A.

AU - Salomaa, V.

AU - Sanders, A. R.

AU - Sarin, A. P.

AU - Schmidt, H.

AU - Scott, R. J.

AU - Smith, B. H.

AU - Smith, J. A.

AU - Staessen, J. A.

AU - Steinhagen-Thiessen, E.

AU - Strauch, K.

AU - Terracciano, A.

AU - Ulivi, S.

AU - Vaccargiu, S.

AU - Quaye, L.

AU - van Rooij, F. J.

AU - Venturini, C.

AU - Vinkhuyzen, A. A.

AU - Völker, U.

AU - Völzke, H.

AU - Vonk, J. M.

AU - Vozzi, D.

AU - Waage, J.

AU - Ware, E. B.

AU - Willemsen, G.

AU - Attia, J. R.

AU - Bennett, D. A.

AU - Berger, K.

AU - Bertram, L.

AU - Bisgaard, H.

AU - Boomsma, D. I.

AU - Borecki, I. B.

AU - Bultmann, U.

AU - Chabris, C. F.

AU - Cucca, Francesco

AU - Cusi, D.

AU - Dedoussis, G. V.

AU - van Duijn, C. M.

AU - Eriksson, J. G.

AU - Franke, B.

AU - Franke, L.

AU - Gasparini, P.

AU - Gejman, P. V.

AU - Gieger, C.

AU - Grabe, H. J.

AU - Gratten, J.

AU - Groenen, P. J.

AU - Gudnason, V.

AU - van der Harst, P.

AU - Hayward, C.

AU - Hinds, D. A.

AU - Hoffmann, W.

AU - Hypponen, E.

AU - Iacono, W. G.

AU - Jacobsson, B.

AU - Järvelin, M. R.

AU - Jöckel, K. H.

AU - Kaprio, J.

AU - Kardia, S. L.

AU - Lehtimäki, T.

AU - Lehrer, S. F.

AU - Magnusson, P. K.

AU - Martin, N. G.

AU - McGue, M.

AU - Pendleton, N.

AU - Penninx, B. W.

AU - Perola, M.

AU - Pirastu, N.

AU - Pirastu, M.

AU - Polasek, O.

AU - Posthuma, D.

AU - Power, C.

AU - Province, M. A.

AU - Samani, N. J.

AU - Schlessinger, D.

AU - Schmidt, R.

AU - Sørensen, T. I.

AU - Spector, T. D.

AU - Stefansson, K.

AU - Thorsteinsdottir, U.

AU - Thurik, A. R.

AU - Timpson, N. J.

AU - Tiemeier, H.

AU - Tung, J. Y.

AU - Uitterlinden, A. G.

AU - Vitart, V.

AU - Vollenweider, P.

AU - Weir, D. R.

AU - Wilson, J. F.

AU - Wright, A. F.

AU - Conley, D. C.

AU - Krueger, R. F.

AU - Smith, G. D.

AU - Hofman, A.

AU - Laibson, D. I.

AU - Medland, S. E.

AU - Meyer, M. N.

AU - Yang, J.

AU - Johannesson, M.

AU - Visscher, P. M.

AU - Koellinger, P. D.

AU - Cesarini, D.

AU - Benjamin, D. J.

PY - 2016/11/22

Y1 - 2016/11/22

N2 - Educational attainment is associated with many health outcomes, including longevity. It is also known to be substantially heritable. Here, we used data from three large genetic epidemiology cohort studies (Generation Scotland, n = ∼17,000; UK Biobank, n = ∼115,000; and the Estonian Biobank, n = ∼6,000) to test whether education-linked genetic variants can predict lifespan length. We did so by using cohort members' polygenic profile score for education to predict their parents' longevity. Across the three cohorts, meta-analysis showed that a 1 SD higher polygenic education score was associated with ∼2.7% lower mortality risk for both mothers (total ndeaths= 79,702) and ∼2.4% lower risk for fathers (total ndeaths= 97,630). On average, the parents of offspring in the upper third of the polygenic score distribution lived 0.55 y longer compared with those of offspring in the lower third. Overall, these results indicate that the genetic contributions to educational attainment are useful in the prediction of human longevity.

AB - Educational attainment is associated with many health outcomes, including longevity. It is also known to be substantially heritable. Here, we used data from three large genetic epidemiology cohort studies (Generation Scotland, n = ∼17,000; UK Biobank, n = ∼115,000; and the Estonian Biobank, n = ∼6,000) to test whether education-linked genetic variants can predict lifespan length. We did so by using cohort members' polygenic profile score for education to predict their parents' longevity. Across the three cohorts, meta-analysis showed that a 1 SD higher polygenic education score was associated with ∼2.7% lower mortality risk for both mothers (total ndeaths= 79,702) and ∼2.4% lower risk for fathers (total ndeaths= 97,630). On average, the parents of offspring in the upper third of the polygenic score distribution lived 0.55 y longer compared with those of offspring in the lower third. Overall, these results indicate that the genetic contributions to educational attainment are useful in the prediction of human longevity.

KW - Education

KW - Genetics

KW - Longevity

KW - Polygenic score

KW - Prediction

UR - https://www.scopus.com/pages/publications/84996555363

U2 - 10.1073/pnas.1605334113

DO - 10.1073/pnas.1605334113

M3 - Article

C2 - 27799538

AN - SCOPUS:84996555363

SN - 0027-8424

VL - 113

SP - 13366

EP - 13371

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 47

ER -

Genetic variants linked to education predict longevity

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this