Genetic association signal near NTN4 in Tourette syndrome

Peristera Paschou; Dongmei Yu; Gloria Gerber; Patrick Evans; Fotis Tsetsos; Lea K. Davis; Iordanis Karagiannidis; Jonathan Chaponis; Eric Gamazon; Kirsten Mueller-Vahl; Manfred Stuhrmann; Monika Schloegelhofer; Mara Stamenkovic; Johannes Hebebrand; Markus Noethen; Peter Nagy; Csaba Barta; Zsanett Tarnok; Renata Rizzo; Christel Depienne; Yulia Worbe; Andreas Hartmann; Danielle C. Cath; Cathy L. Budman; Paul Sandor; Cathy Barr; Thomas Wolanczyk; Harvey Singer; I. Ching Chou; Marco Grados; Danielle Posthuma; Guy A. Rouleau; Harald Aschauer; Nelson B. Freimer; David L. Pauls; Nancy J. Cox; Carol A. Mathews; Jeremiah M. Scharf; T. Wolanzcyk

doi:10.1002/ana.24215

Genetic association signal near NTN4 in Tourette syndrome

Peristera Paschou
, Dongmei Yu
, Gloria Gerber
, Patrick Evans
, Fotis Tsetsos
, Lea K. Davis
, Iordanis Karagiannidis
, Jonathan Chaponis
, Eric Gamazon
, Kirsten Mueller-Vahl
, Manfred Stuhrmann
, Monika Schloegelhofer
, Mara Stamenkovic
, Johannes Hebebrand
, Markus Noethen
, Peter Nagy
, Csaba Barta
, Zsanett Tarnok
, Renata Rizzo
, Christel Depienne

Yulia Worbe, Andreas Hartmann, Danielle C. Cath, Cathy L. Budman, Paul Sandor, Cathy Barr, Thomas Wolanczyk, Harvey Singer, I. Ching Chou, Marco Grados, Danielle Posthuma, Guy A. Rouleau, Harald Aschauer, Nelson B. Freimer, David L. Pauls, Nancy J. Cox, Carol A. Mathews, Jeremiah M. Scharf, T. Wolanzcyk

Democritus University of Thrace
Massachusetts General Hospital
Massachusetts Institute of Technology
The University of Chicago
Hannover Medical School
Medical University of Vienna
University of Duisburg-Essen
University of Bonn
Vadaskert Child and Adolescent Psychiatric Hospital, Budapest, Hungary
Semmelweis University
University of Catania
INSERM, UMR 1127, Paris Brain & Spine Institute (ICM), Paris, France
Sorbonne Université
Centre de Référence National Maladie Rare: 'Syndrome Gilles de la Tourette'
Utrecht University
Amsterdam UMC - Vrije Universiteit Amsterdam
Hofstra University
Northwell Health System
Krembil Research Institute
Youthdale Treatment Centers
Medical University of Warsaw
Johns Hopkins University
China Medical University Taichung
Vrije Universiteit Amsterdam
Erasmus University Rotterdam
McGill University
University of California at Los Angeles
University of California at San Francisco
Brigham and Women’s Hospital

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Tourette syndrome (TS) is a neurodevelopmental disorder with a complex genetic etiology. Through an international collaboration, we genotyped 42 single nucleotide polymorphisms (p < 10-3) from the recent TS genomewide association study (GWAS) in 609 independent cases and 610 ancestry-matched controls. Only rs2060546 on chromosome 12q22 (p = 3.3 × 10-4) remained significant after Bonferroni correction. Meta-analysis with the original GWAS yielded the strongest association to date (p = 5.8 × 10 -7). Although its functional significance is unclear, rs2060546 lies closest to NTN4, an axon guidance molecule expressed in developing striatum. Risk score analysis significantly predicted case-control status (p = 0.042), suggesting that many of these variants are true TS risk alleles. © 2014 American Neurological Association.

Original language	English
Pages (from-to)	310-315
Journal	Annals of neurology
Volume	76
Issue number	2
DOIs	https://doi.org/10.1002/ana.24215
Publication status	Published - 2014

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10.1002/ana.24215

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Paschou, P., Yu, D., Gerber, G., Evans, P., Tsetsos, F., Davis, L. K., Karagiannidis, I., Chaponis, J., Gamazon, E., Mueller-Vahl, K., Stuhrmann, M., Schloegelhofer, M., Stamenkovic, M., Hebebrand, J., Noethen, M., Nagy, P., Barta, C., Tarnok, Z., Rizzo, R., ... Wolanzcyk, T. (2014). Genetic association signal near NTN4 in Tourette syndrome. Annals of neurology, 76(2), 310-315. https://doi.org/10.1002/ana.24215

@article{385178228e9a4451b355a92c1f3eafa8,

title = "Genetic association signal near NTN4 in Tourette syndrome",

abstract = "Tourette syndrome (TS) is a neurodevelopmental disorder with a complex genetic etiology. Through an international collaboration, we genotyped 42 single nucleotide polymorphisms (p < 10-3) from the recent TS genomewide association study (GWAS) in 609 independent cases and 610 ancestry-matched controls. Only rs2060546 on chromosome 12q22 (p = 3.3 × 10-4) remained significant after Bonferroni correction. Meta-analysis with the original GWAS yielded the strongest association to date (p = 5.8 × 10 -7). Although its functional significance is unclear, rs2060546 lies closest to NTN4, an axon guidance molecule expressed in developing striatum. Risk score analysis significantly predicted case-control status (p = 0.042), suggesting that many of these variants are true TS risk alleles. {\textcopyright} 2014 American Neurological Association.",

author = "Peristera Paschou and Dongmei Yu and Gloria Gerber and Patrick Evans and Fotis Tsetsos and Davis, \{Lea K.\} and Iordanis Karagiannidis and Jonathan Chaponis and Eric Gamazon and Kirsten Mueller-Vahl and Manfred Stuhrmann and Monika Schloegelhofer and Mara Stamenkovic and Johannes Hebebrand and Markus Noethen and Peter Nagy and Csaba Barta and Zsanett Tarnok and Renata Rizzo and Christel Depienne and Yulia Worbe and Andreas Hartmann and Cath, \{Danielle C.\} and Budman, \{Cathy L.\} and Paul Sandor and Cathy Barr and Thomas Wolanczyk and Harvey Singer and Chou, \{I. Ching\} and Marco Grados and Danielle Posthuma and Rouleau, \{Guy A.\} and Harald Aschauer and Freimer, \{Nelson B.\} and Pauls, \{David L.\} and Cox, \{Nancy J.\} and Mathews, \{Carol A.\} and Scharf, \{Jeremiah M.\} and T. Wolanzcyk",

year = "2014",

doi = "10.1002/ana.24215",

language = "English",

volume = "76",

pages = "310--315",

journal = "Annals of neurology",

issn = "0364-5134",

publisher = "John Wiley and Sons Inc.",

number = "2",

}

Paschou, P, Yu, D, Gerber, G, Evans, P, Tsetsos, F, Davis, LK, Karagiannidis, I, Chaponis, J, Gamazon, E, Mueller-Vahl, K, Stuhrmann, M, Schloegelhofer, M, Stamenkovic, M, Hebebrand, J, Noethen, M, Nagy, P, Barta, C, Tarnok, Z, Rizzo, R, Depienne, C, Worbe, Y, Hartmann, A, Cath, DC, Budman, CL, Sandor, P, Barr, C, Wolanczyk, T, Singer, H, Chou, IC, Grados, M, Posthuma, D, Rouleau, GA, Aschauer, H, Freimer, NB, Pauls, DL, Cox, NJ, Mathews, CA, Scharf, JM & Wolanzcyk, T 2014, 'Genetic association signal near NTN4 in Tourette syndrome', Annals of neurology, vol. 76, no. 2, pp. 310-315. https://doi.org/10.1002/ana.24215

TY - JOUR

T1 - Genetic association signal near NTN4 in Tourette syndrome

AU - Paschou, Peristera

AU - Yu, Dongmei

AU - Gerber, Gloria

AU - Evans, Patrick

AU - Tsetsos, Fotis

AU - Davis, Lea K.

AU - Karagiannidis, Iordanis

AU - Chaponis, Jonathan

AU - Gamazon, Eric

AU - Mueller-Vahl, Kirsten

AU - Stuhrmann, Manfred

AU - Schloegelhofer, Monika

AU - Stamenkovic, Mara

AU - Hebebrand, Johannes

AU - Noethen, Markus

AU - Nagy, Peter

AU - Barta, Csaba

AU - Tarnok, Zsanett

AU - Rizzo, Renata

AU - Depienne, Christel

AU - Worbe, Yulia

AU - Hartmann, Andreas

AU - Cath, Danielle C.

AU - Budman, Cathy L.

AU - Sandor, Paul

AU - Barr, Cathy

AU - Wolanczyk, Thomas

AU - Singer, Harvey

AU - Chou, I. Ching

AU - Grados, Marco

AU - Posthuma, Danielle

AU - Rouleau, Guy A.

AU - Aschauer, Harald

AU - Freimer, Nelson B.

AU - Pauls, David L.

AU - Cox, Nancy J.

AU - Mathews, Carol A.

AU - Scharf, Jeremiah M.

AU - Wolanzcyk, T.

PY - 2014

Y1 - 2014

N2 - Tourette syndrome (TS) is a neurodevelopmental disorder with a complex genetic etiology. Through an international collaboration, we genotyped 42 single nucleotide polymorphisms (p < 10-3) from the recent TS genomewide association study (GWAS) in 609 independent cases and 610 ancestry-matched controls. Only rs2060546 on chromosome 12q22 (p = 3.3 × 10-4) remained significant after Bonferroni correction. Meta-analysis with the original GWAS yielded the strongest association to date (p = 5.8 × 10 -7). Although its functional significance is unclear, rs2060546 lies closest to NTN4, an axon guidance molecule expressed in developing striatum. Risk score analysis significantly predicted case-control status (p = 0.042), suggesting that many of these variants are true TS risk alleles. © 2014 American Neurological Association.

AB - Tourette syndrome (TS) is a neurodevelopmental disorder with a complex genetic etiology. Through an international collaboration, we genotyped 42 single nucleotide polymorphisms (p < 10-3) from the recent TS genomewide association study (GWAS) in 609 independent cases and 610 ancestry-matched controls. Only rs2060546 on chromosome 12q22 (p = 3.3 × 10-4) remained significant after Bonferroni correction. Meta-analysis with the original GWAS yielded the strongest association to date (p = 5.8 × 10 -7). Although its functional significance is unclear, rs2060546 lies closest to NTN4, an axon guidance molecule expressed in developing striatum. Risk score analysis significantly predicted case-control status (p = 0.042), suggesting that many of these variants are true TS risk alleles. © 2014 American Neurological Association.

UR - https://www.scopus.com/pages/publications/84907598636

UR - https://www.ncbi.nlm.nih.gov/pubmed/25042818

U2 - 10.1002/ana.24215

DO - 10.1002/ana.24215

M3 - Article

C2 - 25042818

SN - 0364-5134

VL - 76

SP - 310

EP - 315

JO - Annals of neurology

JF - Annals of neurology

IS - 2

ER -

Genetic association signal near NTN4 in Tourette syndrome

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