Gastrointestinal polyposis syndromes

Lodewijk A. A. Brosens; W. Arnout van Hattem; Marnix Jansen; Wendy W. J. de Leng; Francis M. Giardiello; G. Johan A. Offerhaus

Gastrointestinal polyposis syndromes

Lodewijk A. A. Brosens
, W. Arnout van Hattem
, Marnix Jansen
, Wendy W. J. de Leng
, Francis M. Giardiello
, G. Johan A. Offerhaus

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

Colorectal cancer is one of the leading causes of cancer-related death in the Western society, and the incidence is rising. Rare hereditary gastrointestinal polyposis syndromes that predispose to colorectal cancer have provided a model for the investigation of cancer initiation and progression in the general population. Many insights in the molecular genetic basis of cancer have emerged from the study of these syndromes. This review discusses the genetics and clinical manifestations of the three most common syndromes with gastrointestinal polyposis and an increased risk of colorectal cancer: familial adenomatous polyposis (FAP), juvenile polyposis (JP) and Peutz-Jeghers syndrome (PJS)

Original language	English
Pages (from-to)	29-46
Journal	Current molecular medicine
Volume	7
Issue number	1
Publication status	Published - 2007

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cite this

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title = "Gastrointestinal polyposis syndromes",

abstract = "Colorectal cancer is one of the leading causes of cancer-related death in the Western society, and the incidence is rising. Rare hereditary gastrointestinal polyposis syndromes that predispose to colorectal cancer have provided a model for the investigation of cancer initiation and progression in the general population. Many insights in the molecular genetic basis of cancer have emerged from the study of these syndromes. This review discusses the genetics and clinical manifestations of the three most common syndromes with gastrointestinal polyposis and an increased risk of colorectal cancer: familial adenomatous polyposis (FAP), juvenile polyposis (JP) and Peutz-Jeghers syndrome (PJS)",

author = "Brosens, \{Lodewijk A. A.\} and \{van Hattem\}, \{W. Arnout\} and Marnix Jansen and \{de Leng\}, \{Wendy W. J.\} and Giardiello, \{Francis M.\} and Offerhaus, \{G. Johan A.\}",

year = "2007",

language = "English",

volume = "7",

pages = "29--46",

journal = "Current molecular medicine",

issn = "1566-5240",

publisher = "Bentham Science Publishers B.V.",

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}

TY - JOUR

T1 - Gastrointestinal polyposis syndromes

AU - Brosens, Lodewijk A. A.

AU - van Hattem, W. Arnout

AU - Jansen, Marnix

AU - de Leng, Wendy W. J.

AU - Giardiello, Francis M.

AU - Offerhaus, G. Johan A.

PY - 2007

Y1 - 2007

N2 - Colorectal cancer is one of the leading causes of cancer-related death in the Western society, and the incidence is rising. Rare hereditary gastrointestinal polyposis syndromes that predispose to colorectal cancer have provided a model for the investigation of cancer initiation and progression in the general population. Many insights in the molecular genetic basis of cancer have emerged from the study of these syndromes. This review discusses the genetics and clinical manifestations of the three most common syndromes with gastrointestinal polyposis and an increased risk of colorectal cancer: familial adenomatous polyposis (FAP), juvenile polyposis (JP) and Peutz-Jeghers syndrome (PJS)

AB - Colorectal cancer is one of the leading causes of cancer-related death in the Western society, and the incidence is rising. Rare hereditary gastrointestinal polyposis syndromes that predispose to colorectal cancer have provided a model for the investigation of cancer initiation and progression in the general population. Many insights in the molecular genetic basis of cancer have emerged from the study of these syndromes. This review discusses the genetics and clinical manifestations of the three most common syndromes with gastrointestinal polyposis and an increased risk of colorectal cancer: familial adenomatous polyposis (FAP), juvenile polyposis (JP) and Peutz-Jeghers syndrome (PJS)

M3 - Review article

C2 - 17311531

SN - 1566-5240

VL - 7

SP - 29

EP - 46

JO - Current molecular medicine

JF - Current molecular medicine

IS - 1

ER -

Gastrointestinal polyposis syndromes

Abstract

UN SDGs

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